Natural Involution of Acute Retinopathy of Prematurity Not Requiring Treatment: Factors Associated With the Time Course of Involution

Ni, Yushan; Huang, Xin; Xue, Kang; Yu, Jia-Kuo; Ruan, Lu; Shan, Hangguan; Xu, Gezhi

doi:10.1167/iovs.13-13744

Cited by 33 publications

(31 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Banerjee et al found that low haemoglobin levels at birth were associated with increased morbidities, including ROP (15). In a retrospective case series of 82 eyes who had milder ROP not warranting treatment, anaemia was found to be one of the predictive risk factor for delayed involution of ROP (25) and timely blood transfusions have been suggested as a way of initiating the regression of ROP (14).…”

Section: Discussionmentioning

confidence: 99%

Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity

et al. 2018

View full text Add to dashboard Cite

Aim This study evaluated the correlation between retinopathy of prematurity (ROP), anaemia and blood transfusions in extremely preterm infants. Methods We included 227 infants born below 28 weeks of gestation at King Edward Memorial Hospital, Perth, Australia, from 2014–2016. Birth characteristics and risk factors for ROP were retrieved, and anaemia and severe anaemia were defined as a haemoglobins of <110 g/L and <80 g/L, respectively. Logistic regression was used for the analysis. Results Retinopathy of prematurity treatment was needed in 11% of cases and the mean number of blood transfusions (p < 0.01), and mean number of weeks of anaemia (p < 0.001) and of severe anaemia (p < 0.05), had positive associations with ROP cases warranting treatment. In the multivariate logistic regression analysis, the best-fit model of risk factors included anaemic days during first week of life, with an odds ratio (OR) of 1.46% and 95% confidence interval (CI) of 1.16–1.83 (p < 0.05), sepsis during the first 4 weeks of life (OR 3.14, 95% CI 1.10–9.00, p < 0.05) and days of ventilation (OR 1.03, 95% CI 1.01–1.06, p < 0.05). Conclusion The duration of anaemia during the first week of life was an independent risk factor for ROP warranting treatment and preventing early anaemia may decrease this risk.

show abstract

Section: Discussionmentioning

confidence: 99%

Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity

et al. 2018

View full text Add to dashboard Cite

show abstract

“…2 To date, ROP has been a leading cause of childhood blindness, particularly in the middle-income developing countries in Asia. 3 Compared to developed countries, bigger and more mature infants in China also develop severe ROP, so early diagnosis and timely treatment are important for preventing the progression of ROP. 4,5 Nevertheless, there are limited studies among preterm infants in China.…”

mentioning

confidence: 99%

Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors

Zhang

et al. 2018

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

show abstract

“…A favorable ROP outcome was assigned if the retinal vessels progressed to full vascularization in both eyes without meeting criteria for severe ROP, or if on two consecutive examinations the retinal vessels were in zone III(16). Examinations were continued, if necessary, up to 55 weeks PMA (3 months after term due date)(19,20). Infants who did not meet either criterion had all available examinations reviewed by an adjudication committee.…”

Section: Methodsmentioning

confidence: 99%

Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants

et al. 2016

View full text Add to dashboard Cite

BACKGROUND Preterm infants with RDS given inositol had reduced BPD, death and severe ROP. We assessed the safety and pharmacokinetics(PK) of daily inositol to select a dose providing serum levels previously associated with benefit, and to learn if accumulation occurred when administered throughout the normal period of retinal vascularization. METHODS Infants ≤29wks GA (n=122, 14 centers) were randomized and treated with placebo or inositol at 10, 40 or 80mg/kg/day. Intravenous administration converted to enteral when feedings were established, and continued to the first of 10 weeks, 34weeks PMA or discharge. Serum collection employed a sparse sampling population PK design. Inositol urine losses and feeding intakes were measured. Safety was prospectively monitored. RESULTS At 80mg/kg/day mean serum levels reached 140mg/L, similar to Hallman’s findings. Levels declined after 2 weeks, converging in all groups by 6 wks. Analyses showed a mean volume of distribution 0.657 L/kg, clearance 0.058 L/kg/hr, and half-life 7.90 hr. Adverse events and co-morbidities were fewer in the inositol groups, but not significantly so. CONCLUSIONS Multiple dose inositol at 80mg/kg/day was not associated with increased adverse events, achieves previously effective serum levels, and is appropriate for investigation in a Phase 3 trial.

show abstract

Natural Involution of Acute Retinopathy of Prematurity Not Requiring Treatment: Factors Associated With the Time Course of Involution

Abstract: The natural involution of acute ROP not requiring treatment correlated better with severity than with ROP location. Active stage 3 disease, CPAP, and anemia were predictive risk factors for delayed involution of ROP.

Cited by 33 publications

References 23 publications

Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity

Duration of anaemia during the first week of life is an independent risk factor for retinopathy of prematurity

Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors

Safety and pharmacokinetics of multiple dose myo-inositol in preterm infants

Contact Info

Product

Resources

About