Natural Killer Cell Activity in Patients with Multiple Sclerosis: Interferon and Plasmapheresis

Uchida, Atsushi; Maida, E.; Lenzhofer, R; Micksche, M.

doi:10.1016/s0171-2985(82)80003-x

Cited by 27 publications

(11 citation statements)

References 20 publications

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“…in rheumatoid synovial tissue [34–36] and among infiltrating mononuclear cells of MS patient brain lesions [37]). Reduced peripheral NK cell activities and, in some studies, also differences in NK cell numbers are found when patients suffering from various autoimmune syndromes, such as remitting/relapsing (r/r) MS [38–42], Sjögren's Syndrome (SS) [41, 43–45], MG [46], rheumatoid arthritis (RA) [47–50], SLE [43, 47, 51, 52] and type 1 diabetes [53–56], are studied and compared with controls. It has, however, been difficult to determine whether these qualitative and quantitative alterations stem from metabolic disturbances, the therapy used or whether they represent a primary NK cell defect that could have played a pathogenic role [55–60].…”

Section: Autoimmune Diseasementioning

confidence: 99%

The Natural Killer Cell – Friend or Foe in Autoimmune Disease?

et al. 2002

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Autoimmune diseases are chronic conditions resulting from a loss of immunological tolerance to self‐antigens. Recent observations have supported an ever‐broader role for innate immune responses in directing and regulating adaptive immunity, including responses to self. This review summarizes recent findings supporting important functions of natural killer (NK) cells in regulating autoimmunity. A close survey of the current literature reveals multiple steps where NK cells can regulate inflammation and intervene in loss of self‐tolerance. Importantly, the findings also caution against inferring a similar role for NK cells in all autoimmune phenomena or during separate stages of the same disease. Indeed, NK cells may have different influences during the priming and the effector phases of disease. Hence, an increased understanding of the involvement of NK cells in inflammation and infection should provide new insights into the pathogenesis of autoimmune disease.

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Section: Autoimmune Diseasementioning

confidence: 99%

The Natural Killer Cell – Friend or Foe in Autoimmune Disease?

et al. 2002

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“…MS represents a multifactorial immunological abnormality associated with a strong deficiency of NK activity [14][15][16][17] probably caused by a functional defect of the IFN system. 18,35 This IFN-dependent NK deficiency is linked with a reduction in IFN production by practically all types of cells involved in the process.…”

Section: Resultsmentioning

confidence: 99%

Autologous Enhancement by Interferon of Natural Killer Activity ofHuman Peripheral Blood Lymphocytes

Чекнев¹,

Ashmanova²,

Pritsker³

et al. 1994

Mediators of Inflammation

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The in vitro action of interferon (IFN)-α and IFN-γ from six healthy donors and ten patients with multiple sclerosis (MS) on natural killer (INK) activity of peripheral blood lymphocytes (PBL) was studied in an autologous system. The NK activity of PBL was detected by a cytotoxic test using 3H-uridine human erythromyeloblast K562 cells. Autologous IFN-α and IFN-γ did not augment NK activity of PBL from healthy donors in vitro, whereas in samples from MS patients the IFNs strongly stimulated NK cell cytotoxic function. This stimulation suggests the existence of an inhibitor of regulatory IFN action, that is produced in healthy donors simultaneously with IFN in response to IFN induction, but which is lacking in commercial IFN preparations. The factor-containing supernatants from healthy donors reduced the stimulatory action of autologous IFNs in patients with MS almost until complete blockade. Because this inhibitor was absent in patients with MS, deficiency of an inhibitor of IFN regulatory action in MS could open the way to treatment of this compartment of the immune system.

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“…Moreover, NK cells isolated from patients with MS were found not only to be decreased in frequency, but also to be impaired in effector function (58)(59)(60)(61)(62)(63)(64)(65)(66)(67)(68). Notably, patients with hemophagocytic lymphohistiocytosis (HLH), a rare condition characterized by impaired or absent function of the perforin/ granzyme system in NK cells and cytotoxic T-cells, demonstrated decreased NKcell activity.…”

Section: Nk-cell (Dys)function In Human Autoimmune Diseasesmentioning

confidence: 99%

Regulatory NK-Cell Functions in Inflammation and Autoimmunity

Lünemann

Münz

2009

Mol Med

116

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Natural killer (NK) cells were viewed traditionally as cytotoxic effector cells whose rapid killing of infected and transformed cells without preactivation provides a first line of defense prior to the initiation of an adaptive immune response against infection and tumor development. However, it has become clear that NK cells interact with various components of the immune system, and therefore have the potential to function as regulatory cells. While NK cells can assist in dendritic cell (DC) maturation and T-cell polarization, increasing evidence indicates that NK cells can also prevent and limit adaptive (auto) immune responses via killing of autologous myeloid and lymphoid cells. Investigating immunoregulatory NK-cell functions might generate exciting insights into the reciprocal regulation between NK-cell-mediated innate immunity and adaptive immune responses, improve our capacity to monitor these cells as surrogate markers for disease activity and treatment responses in autoimmune diseases, and, perhaps, provide new prospects for NK cell-directed therapies.

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Natural Killer Cell Activity in Patients with Multiple Sclerosis: Interferon and Plasmapheresis

Cited by 27 publications

References 20 publications

The Natural Killer Cell – Friend or Foe in Autoimmune Disease?

The Natural Killer Cell – Friend or Foe in Autoimmune Disease?

Autologous Enhancement by Interferon of Natural Killer Activity ofHuman Peripheral Blood Lymphocytes

Regulatory NK-Cell Functions in Inflammation and Autoimmunity

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