Natural Killer Cell Activity in Systemic Lupus Erythematosus

Oshimi, Kazuo; Sumiya, M; Gonda, N; Kano, Shogo; Takaku, Fumimaro

doi:10.1016/s0140-6736(79)92603-5

Cited by 29 publications

(21 citation statements)

References 5 publications

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“…The close-to-normal responders, on the other hand, had only glandular disease with or without RA. Conforming to the previous reports (21,22), the patients with SLE who had not been treated before showed severe depression of NK augmentability, whereas those with RA had normal NK activity. In contrast to these chronic inflammatory diseases, the patients who had acute hepatitis and lymphoadenopathy most likely due to viral infections clearly showed transiently elevated endogenous NK activity with further augmentation by HeLa-Ms cell stimulation.…”

Section: Resultssupporting

confidence: 74%

“…Neither endogenous nor augmented NK activity in these patients was depressed. Using K562 as target cells, it was reported that the patients with SLE had reduced NK activity (21,22). As also shown in Fig.…”

Section: Resultsmentioning

confidence: 78%

“…None of these patients had been receiving corticosteroids, which is shown to depress NK activity (25). Some of these with SS were receiving nonsteroidal antiinflammatory drugs including aspirin.…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Studies of the function of natural killer-interferon system in patients with Sjögren syndrome.

Minato¹,

Takeda²,

Kano³

et al. 1982

J. Clin. Invest.

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Section: Resultssupporting

confidence: 74%

Section: Resultsmentioning

confidence: 78%

See 1 more Smart Citation

Studies of the function of natural killer-interferon system in patients with Sjögren syndrome.

Minato¹,

Takeda²,

Kano³

et al. 1982

J. Clin. Invest.

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“…In this context, glucocorticoids profoundly reduce NK cytotoxic activity at both physiological and pharmacological concentrations [12][13][14][15][16]. In fact, cortisol can inhibit [17,18], thus affecting the cytotoxic mechanism leading to exocytic release of lytic enzymes [19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Decreased Immunosuppressive Effect of Cortisol on Natural Killer Cytotoxic Activity in Senile Dementia of the Alzheimer Type

Solerte

Cerutti

Severgnini

et al. 1998

Dement Geriatr Cogn Disord

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Former studies have indicated alterations of the cytotoxic activity of natural killer (NK) cells in senile dementia of the Alzheimer type (SDAT). These changes may be related to the increased reactivity of NK cells with cytokines, even if an impairment of the immunosuppressive effect of glucocorticoids cannot be excluded. In the present study we have demonstrated a lower immunosuppressive effect of cortisol on NK cytolytic function in patients with SDAT than in healthy elders and in patients with dementia of multi-infarct origin (MID). This suppression is completely lacking when cortisol is employed at low concentrations (10^–7 M) and is significantly reduced after incubation at physiological (10^–6 M; p < 0.001) and supraphysiological concentrations (10^–5 M; p < 0.001). The addition of IL-2 (50 and 100 IU/ml/cells) significantly antagonizes the effects of cortisol in SDAT, whereas the cortisol-dependent immunosuppression is partially maintained in healthy elders and in patients with MID. Our data indicate that the defect of the immunosuppressive effect of cortisol may play a role in NK dysregulation in SDAT, contributing to the cytokine-mediated NK overactivity in this disease.

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“…NK cells are known for their innate defense against herpesviruses 3 and can be suppressed in the setting of steroids. 4 Transient NK cell deficiency may have enabled dissemination of the virus throughout the nervous system.…”

Section: Practical Implicationsmentioning

confidence: 99%

Disseminated HSV-2 presenting with relapsing encephalomyelitis

et al. 2016

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A previously healthy 39-year-old woman presented with 3 weeks of progressive leg numbness. Examination showed mild bilateral iliopsoas weakness and patchy leg numbness. She was admitted, and spinal MRI revealed T2 enhancing thoracic lesions, nonenhancing cervical cord lesions (figure, A), and subtle pial and cauda equina enhancement (figure, B). Brain MRI revealed multiple periventricular T2 hyperintensities (figure, C). Since the diagnosis of multiple sclerosis (MS) was considered likely, lumbar puncture (LP) was deferred and she received 5 days of IV methylprednisolone. One week later, she developed increasing right-sided hearing loss and vertigo with right cochlear enhancement (figure, D). Two weeks later, a morbilliform and vesicular flank and trunk rash appeared (figure, E and F). She was readmitted and treated with IV acyclovir for presumed disseminated varicella zoster virus (VZV). LP revealed a lymphocytic pleocytosis (90 leukocytes, 100% lymphocytes) and elevated protein (150 mg/dL). Oligoclonal bands were positive, and neuromyelitis optica and human T-cell lymphotropic virus-1 antibodies were negative. A PCR encephalitis panel was positive for herpes simplex virus (HSV)-2 and negative for VZV and HSV-1. Skin biopsy viral culture and PCR were positive for HSV. Three weeks after rash onset, the patient developed worsening leg numbness, received 5 more days of IV methylprednisolone, and soon after developed severe ataxia and weakness. Repeat MRI revealed new pontine lesions atypical for MS, punctate lesions following a vascular distribution, and new enhancing spinal cord lesions ( figure, G and H). Repeat LP revealed a decreasing leukocyte count (17 leukocytes) and rising protein (298 mg/dL). CSF HSV-2 PCR was now negative, yet quantitative ELISA revealed positive HSV-2 immunoglobulin G (IgG) (8.83 antibody index [AI]) and negative HSV-1 IgG (0.3 [reference range 0.9 AI]). CSF HSV-1 and HSV-2 immunoglobulin M (IgM) (1.15) and IgG titers were elevated (27.93 [reference range 0.9 AI]). A unifying diagnosis of HSV-2 encephalomyelitis was made. The patient was treated with plasmapheresis, followed by IV immunoglobulin (IVIG), concurrently with 6 weeks of IV acyclovir. A follow-up LP 3 weeks after treatment initiation demonstrated decreasing HSV IgM (0.22 AI) and IgG (7.96 AI) titers, pleocytosis (6 leukocytes), and protein (111 mg/dL), consistent with declining inflammation. Monthly follow-up imaging showed interval resolution of spinal enhancement and no new lesions, commensurate with resolving sensory symptoms and ataxia.

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Natural Killer Cell Activity in Systemic Lupus Erythematosus

Cited by 29 publications

References 5 publications

Studies of the function of natural killer-interferon system in patients with Sjögren syndrome.

Studies of the function of natural killer-interferon system in patients with Sjögren syndrome.

Decreased Immunosuppressive Effect of Cortisol on Natural Killer Cytotoxic Activity in Senile Dementia of the Alzheimer Type

Disseminated HSV-2 presenting with relapsing encephalomyelitis

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