Natural killer cell activity in workers exposed to benzidine and beta-naphthylamine.

Tanigawa, Takeshi; Araki, Shunichi; Ishizu, Sumiko; Morita, Tatsuo; Okazaki, Hidenori; Minato, Nagahiro

doi:10.1136/oem.47.5.338

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…These findings are of interest because no other immunological activity has been demonstrated in cancer patients except for NK activity, which was shown to be depressed at an early stage of cancer. NK cells play an important role in immune surveillance against tumors (Herberman, 1982), and suppression of NK activity is related to canceration (Tanigawa et al, 1990). AMLR might also reflect immune surveillance against tumors and the disturbance of self-recognition manifested by suppression of the AMLR might be related to the canceration.…”

Section: Discussionmentioning

confidence: 99%

Defective autologous mixed lymphocyte reaction (AMLR) and killer activity generated in the AMLR in cancer patients

Itō¹,

Tanimura²,

Yamaue³

et al. 1992

Intl Journal of Cancer

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The autologous mixed lymphocyte reaction (AMLR) and the killer activity generated in the AMLR (AMLR-killer) in the spleen and the peripheral blood of patients with gastric cancer were investigated. The AMLR in cancer patients was suppressed, especially in the spleen, compared to that seen in controls. There was no correlation between AMLR activity and the stage status of the cancer. The cytotoxic activity of AMLR-killer cells against various tumor-cell lines was also suppressed in the spleen, and had a tendency to be suppressed in the peripheral blood of cancer patients. The autologous tumor-killing activity of AMLR-killer cells was developed in cancer patients with high AMLR activity, but was not induced in patients with low AMLR activity. Autotumor killing activity was decreased by the elimination of CD4+ cells, whereas the elimination of CD16+ cells resulted in a marked reduction in cytotoxicity against K562, indicating that the non-specific killer cells which lysed K562 were different from the specific killer cells that lysed autotumor cells. This suggests that AMLR activity is related to the differentiation and proliferation of lymphocytes with specific or non-specific cytotoxic activity and that this activity plays an important role in immune surveillance against tumors.

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Section: Discussionmentioning

confidence: 99%

Defective autologous mixed lymphocyte reaction (AMLR) and killer activity generated in the AMLR in cancer patients

Itō¹,

Tanimura²,

Yamaue³

et al. 1992

Intl Journal of Cancer

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“…Benzidine and b-naphthylamine have been implicated as triggers for transitional cell metaplasia predisposing to the development of bladder cancer. One study of workers exposed to these chemicals reported increased circulating NK cells, but decreased function, in these subjects compared to normal controls [7]. Other conditions associated with diminished NK function include pregnancy [92], psychiatric depression [6], thermal injuries [93], strenuous exercise [94] and malignancy [95][96][97].…”

Section: Role Of Nk Cells In Viral Infections In Humansmentioning

confidence: 99%

“…Mounting evidence suggests that these cells are important in the early response of the immune system to many viral infections [1]. Although acquired deficiency in NK function has been described in the chronic fatigue syndrome (CFS) [2], human immunodeficiency virus (HIV) infection [3], metastatic carcinoma [4], autoimmune disorders [5], depression [6] and exposure to occupational chemicals [7]; the clinical significance of the reduced NK function in these disorders has not been established. The Chediak-Higachi syndrome [8] and leucocyte adhesion deficiency [9] are genetic disorders characterized by profiles of depressed immune response, each of which includes a depression of NK-cell function.…”

Section: Introductionmentioning

confidence: 99%

The Role of Natural Killer Cells in Viral Infections

et al. 1997

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Natural killer (NK) cells are important effectors for the lysis of both neoplastic and virus‐infected cells. Lectin‐like receptors on human NK cells, such as NKR‐PIA and CD94, bind to target cell carbohydrate ligands and initiate the lytic process. In addition, P58 and P70 bind to major histocompatibility class I antigens on targets and mediate negative signals. Models using NK cell‐deficient mice have proven useful in elaborating the role of NK cells in the immune defence against multiple viral agents. In addition, studies in humans have suggested a vital role of NK cells in the host defence against human immunodeficiency virus, herpesviruses, hepatitis B and C and other viruses. Several genetic disorders, chronic illnesses and infections have been associated with decreased NK function.

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Increase in CD57+CD16-lymphocytes in workers exposed to benzidine and beta-naphthylamine: assessment of natural killer cell subpopulations

Tanigawa

Araki

Abo

et al. 1996

Int. Arch Occup Environ Heath

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Previously, we found a decrease in CD4 + CD45RA + T lymphocytes in workers exposed to the aromatic amines (AAs) [benzidine (BZ) and beta naphthylamine (BNA)]. For further investigation of the effects of AAs on lymphocyte subpopulations, we measured natural killer (NK) cell subpopulations using two-color staining with anti-Leu7 (CD57) and anti-Leu11 (CD16) monoclonal antibodies in peripheral blood in 78 male dyestuff workers. The workers had been exposed to AAs before 1972 at a chemical plant, either in the production of AAs (40 workers, high-exposure group) or in other work that involved handling dyestuffs (38 workers, low-exposure group). The controls were 30 "healthy" male volunteers without a history of occupational exposure to AAs or hazardous chemicals. The number of CD57 + CD16- cells in the high-exposure group was significantly higher than that in the controls (P < 0.01, analysis of covariance with age as a covariate). No significant differences were found in CD57 + CD16-, CD57 + CD16+ and CD57- CD16 + NK cells between the low-exposure group and the controls. It is suggested that a decrease in the number of CD4+ T lymphocytes following exposure to AAs might be compensated by the increase in CD57 + CD16- cells, i.e. circulating peripheral lymphocytes with poor NK cell activity.

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Natural killer cell activity in workers exposed to benzidine and beta-naphthylamine.

Abstract: To investigate the effects of benzidine (BZ) and /I-naphthylamine (BNA)

Cited by 6 publications

References 15 publications

Defective autologous mixed lymphocyte reaction (AMLR) and killer activity generated in the AMLR in cancer patients

Defective autologous mixed lymphocyte reaction (AMLR) and killer activity generated in the AMLR in cancer patients

The Role of Natural Killer Cells in Viral Infections

Increase in CD57+CD16-lymphocytes in workers exposed to benzidine and beta-naphthylamine: assessment of natural killer cell subpopulations

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