Natural killer cell activity in untreated systemic lupus erythematosus

Oshimi, Kazuo; Sumiya, M; Gonda, N; Kano, Shogo; Takaku, Fumimaro

doi:10.1136/ard.41.4.417

Cited by 10 publications

(3 citation statements)

References 16 publications

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“…Reports of NK cell deficits in autoimmune diseases are increasing (8,9). However, in Graves' disease (GD), a well-known autoimmune disease, this deficiency has not been established clearly.…”

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confidence: 99%

Impaired natural killer cytotoxicity in peripheral blood mononuclear cells in Graves' disease

Marazuela

Vargas²,

Álvarez‐Mon³

et al. 1995

European Journal of Endocrinology

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We studied the natural killer (NK) activity of peripheral blood mononuclear cells (PBMC) in patients with Graves' disease (GD). Peripheral blood mononuclear cells from 20 untreated hyperthyroid patients with GD showed a significantly reduced NK activity against 51 Cr-labeled K562 cells (33.9 +/- 15.9%), while in 32 euthyroid patients under antithyroid drug therapy. NK activity was similar to that of controls (46.9 +/- 17.3 and 49.9 +/- 20.2%, respectively). Furthermore, normalization of thyroid function with antithyroid drugs was associated with a significant increase and normalization of NK activity during the follow-up of nine GD patients (from 29.2 +/- 17.9 to 48.1 +/- 16.5%). This phenomenon could not be ascribed to a defective number of NK cells because the amounts of CD56+ and CD16+ cells in PBMC from both hyperthyroid and euthyroid GD patients were within normal ranges. Natural killer activity of PBMC from patients with toxic multinodular goiter was similar to that of normal controls (45 +/- 12.8 to 49.9 +/- 20%). No correlation was found between natural killer activity and serum levels of free thyroxine, TSH-inhibitory immunoglobulins, thyroidal antibodies to thryoglobulin and thyroidal microsomal antigen, dose or duration of antithyroid drug therapy. Natural killer activity from both controls and GD patients was enhanced in vitro by addition of recombinant interleukin 2 (IL-2), reaching control levels in hyperthyroid patients. These abnormalities were not associated with a defective IL-2 production by T cells, nor with a decreased IL-2R expression. We conclude that in untreated Graves' disease there is a decrease in NK cell activity in PBMC, probably dependent on the autoimmune process.(ABSTRACT TRUNCATED AT 250 WORDS)

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confidence: 99%

Impaired natural killer cytotoxicity in peripheral blood mononuclear cells in Graves' disease

Marazuela

Vargas²,

Álvarez‐Mon³

et al. 1995

European Journal of Endocrinology

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“…lymphocyte differentiation (14), secreting B cell growth factor (13, suppressing immunoglobulin synthesis (16,17), and lysing the antigen-presenting accessory cells crucial for sustaining B and T lymphocyte proliferation (18). Indeed, NK cell abnormalities have been described in a number of rheumatic diseases, such as rheumatoid arthritis (19-22), Sjogren's syndrome (22-25), mixed connective tissue disease (26), polymyositis (27), and systemic lupus erythematosus(28)(29)(30)(31)(32), and in several immunologically mediated nonrheumatic diseases, e.g., sarcoidosis(33), atopic…”

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confidence: 99%

Reduced natural killer cell activity in patients with systemic sclerosis

Miller

Hiserodt

Hunt

et al. 1988

Arthritis & Rheumatism

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Natural killer (NK) cell number and function were determined in 69 systemic sclerosis (SSc) patients (41 with diffuse cutaneous SSc, 24 with limited cutaneous SSc, and 4 with scleroderma in an overlap syndrome). The results were compared with those obtained from 5 patients with Raynaud's disease and from 27 normal controls. Natural and antibody-dependent killing was reduced in the total group of SSc patients compared with controls, but these differences were primarily attributable to patients with the diffuse form of the disease who were seen early in their illness (<5 years after onset). NK cell numbers were not significantly reduced in patients compared with controls, although lower numbers were observed in individuals with early diffuse disease. Other clinical parameters, such as treatment with D-penicillamine or the presence of scleroderma-specific autoantibodies, did not exert an independent effect on NK cell function. These findings suggest a possible central role for NK cells in the pathogenesis of SSc.

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“…NK activity was expressed as E (Effector cell)/T (Target cell) ratio (referred range; E:T ratio = 20:1: 17.1–48.7%, E:T ratio = 10:1: 8.9–29.5%) . We divided all patients into the two groups by 17.1% of the lytic unit at E:T ratio of 20:1 as borderline of reduced NK cell activity, since this E:T ratio is optimal in 51 Cr‐relasing assay .…”

Section: Methodsmentioning

confidence: 99%

Association of Increased Indoleamine 2, 3‐Dioxygenase With Impaired Natural Killer Cell Activity in Hemodialysis Patients

et al. 2013

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Indoleamine 2, 3-dioxygenase (IDO) suppresses adaptive immune response. However, there was no study to examine whether IDO activity is associated with immune parameters in dialysis patients. In this study, we estimated serum IDO activity by the kynurenine/tryptophan ratio (KTR), and compared KTR with natural killer (NK) cell activity, soluble interleukin-2 receptor (sIL-2R) and serum levels of trace elements such as selenium (Se) and zinc (Zn) that affect T-cell function in 28 hemodialysis (HD) patients (age: 72 ± 13 years old, time on HD: 79 ± 89 months). NK cell activity was decreased in 35.7% of the patients. KTR values were almost 10-times higher in HD patients (380.81 ± 385.46 mM/M) than those in the referred controls (32.9 ± 9.10 mM/M). KTR was lower in patients with impaired NK cell activity than those without (279 ± 111 vs. 565 ± 603 mM/M, P = 0.07). There was no relationship between KTR and sIL-2R and Zn, while KTR was significantly and negatively correlated with serum Se levels that can impair cellular immunity (r = -0.41, P < 0.05). Our findings suggest that increased IDO activity with Se deficiency may be associated with impaired NK cell function in HD patients.

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Natural killer cell activity in untreated systemic lupus erythematosus

Cited by 10 publications

References 16 publications

Impaired natural killer cytotoxicity in peripheral blood mononuclear cells in Graves' disease

Impaired natural killer cytotoxicity in peripheral blood mononuclear cells in Graves' disease

Reduced natural killer cell activity in patients with systemic sclerosis

Association of Increased Indoleamine 2, 3‐Dioxygenase With Impaired Natural Killer Cell Activity in Hemodialysis Patients

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