Natural killer cell crossmatch: Functional analysis of inhibitory killer immunoglobulin-like receptors and their HLA ligands

Han, Mei; Fallena, Margarita; Guo, Yuhong; Šťastný, Peter

doi:10.1016/j.humimm.2007.02.001

Cited by 7 publications

(4 citation statements)

References 27 publications

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“…Binding of iKIR (designated 2DL and 3DL) to specific HLA allotypes has been clearly demonstrated and correlated to the ability to inhibit NK cytolysis of target cells bearing these HLA molecules. These interactions are remarkably complex, and synergistic relationship between these polymorphic loci may regulate NK cell-mediated immunity against viral infections [28]. …”

Section: Discussionmentioning

confidence: 99%

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Marangon

Guelsin

Visentainer

et al. 2013

BioMed Research International

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The genetic variability of the host contributes to the risk of human papillomavirus (HPV)-related cervical disease. Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease. The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs) of cytokines with HPV-related cervical disease. We selected 79 non-related, admixed Brazilian women from the state of Paraná, southern region of Brazil, who were infected with high carcinogenic risk HPV and present cervical intraepithelial neoplasia grade 3 (CIN3), and 150 HPV-negative women from the same region matched for ethnicity. KIR genes were genotyped using an in-house PCR-SSP. HLA alleles were typed using a reverse sequence-specific oligonucleotide technique. SNPs of TNF −308G>A, IL6 −174G>C, IFNG +874T>A, TGFB1 +869T>C +915G>C, and IL10 −592C>A −819C>T −1082G>A were evaluated using PCR-SSP. The KIR genes were not associated with HPV, although some pairs of i(inhibitory)KIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis. Some HLA haplotypes were associated with HPV. The associations of INFG and IL10 SNPs potentially reflect impaired or invalid responses in advanced lesions.

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Section: Discussionmentioning

confidence: 99%

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Marangon

Guelsin

Visentainer

et al. 2013

BioMed Research International

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“…This characteristic can be seen in the low frequency of four pairs of inhibitory KIR/HLA reported in this study (6.4%). Han et al [46] correlated a smaller number of inhibitory KIR/HLA combinations with a higher percentage of cytotoxicity by NK cells.…”

Section: Discussionmentioning

confidence: 99%

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná

et al. 2008

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“…[ 23 ] Similarly, the same approach resulted in decreased survival following KIR-HLA ligand mismatched allografts in some other studies. [ 24 ] These results have been attributed to the heterogeneity of treatment protocols and patient cohorts.…”

Section: Discussionmentioning

confidence: 99%

Impact of killer immunoglobulin-like receptor-human leukocyte antigens ligand incompatibility among renal transplantation

et al. 2015

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Killer immunoglobulin-like receptor (KIR) gene shows a high degree of polymorphism. Natural killer cell receptor gets activated once they bind to self-human leukocyte antigens (HLAs) with specific ligand. KIR gene and HLA ligand incompatibility due to the presence/absence of KIR in the recipient and the corresponding HLA ligand in the allograft may impact graft survival in solid organ transplantation. This study evaluates the effect of matches between KIR genes and known HLA ligands. KIR genotypes were determined using sequence specific primer polymerase chain reaction. Presence of certain KIR in a recipient, where the donor lacked the corresponding HLA ligand was considered a mismatch. The allograft was considered matched when both KIR receptor and HLA alloantigen reveald compatibility among recipient and donor. The data revealed better survival among individuals with matched inhibitory KIR receptors and their corresponding HLA ligands (KIR2DL2/DL3-HLAC2, KIR3DL1-HLABw4). On the contrary, no adverse effect was seen for matched activating KIR receptors and their corresponding HLA ligands. One of the activating gene KIR2DS4 showed risk (P = 0.0413, odds ratio = 1.91, 95% confidence interval = 1.02-3.57) association with renal allograft rejection. We conclude that the presence of inhibitory KIR gene leads to better survival; whereas activating motifs show no significant role in renal allograft survival.

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Natural killer cell crossmatch: Functional analysis of inhibitory killer immunoglobulin-like receptors and their HLA ligands

Cited by 7 publications

References 27 publications

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Killer cell immunoglobulin-like receptor gene diversity in a Southern Brazilian population from the state of Paraná

Impact of killer immunoglobulin-like receptor-human leukocyte antigens ligand incompatibility among renal transplantation

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