Natural killer cell cytotoxicity shapes the clonal evolution of B cell leukaemia
Michelle C. Buri,
Mohamed R. Shoeb,
Aleksandr Bykov
et al.
Abstract:The term cancer immunoediting describes the dual role by which the immune system can both suppress and promote tumour growth and is divided into three phases: elimination, equilibrium and escape. While the importance of CD8+T cells in all three phases of cancer immunoediting is well-established, the role of NK cells has mainly been attributed to the elimination phase. Here we show that NK cells play a prominent role in all three phases of cancer immunoediting. Extended co-culturing of DNA barcoded mouse BCR/AB… Show more
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