2018
DOI: 10.20944/preprints201810.0450.v1
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Natural Killer Cell Dysfunction in Hepatocellular Carcinoma: Pathogenesis and Clinical Implications

Abstract: Hepatocellular carcinoma (HCC) is currently the third leading cause of malignancy-related mortalities worldwide. Natural killer (NK) cells are involved in the critical role of first line immunological defense against cancer development. Defects in NK cell functions are recognized as important mechanisms for immune evasion of tumor cells. NK cell function appears to be attenuated in HCC, and many previous reports suggested that NK cells play a critical role in controlling HCC, suggesting that boosting the activ… Show more

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Cited by 10 publications
(1 citation statement)
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References 97 publications
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“…HCC is a typical example of malignancy associated with nonresolving inflammation (33)(34)(35). However, HCC is recognized as an immune-tolerant malignancy (36). Only 14% to 18% of patients who receive pembrolizumab or nivolumab monotherapy demonstrate objective tumor responses (37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%
“…HCC is a typical example of malignancy associated with nonresolving inflammation (33)(34)(35). However, HCC is recognized as an immune-tolerant malignancy (36). Only 14% to 18% of patients who receive pembrolizumab or nivolumab monotherapy demonstrate objective tumor responses (37)(38)(39).…”
Section: Discussionmentioning
confidence: 99%