Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies

Mxinwa, Vuyolwethu; Dludla, Phiwayinkosi V.; Nyambuya, Tawanda M.; Mokgalaboni, Kabelo; Mazibuko-Mbeje, Sithandiwe E.; Nkambule, Bongani B.

doi:10.1186/s12865-020-00378-5

Cited by 15 publications

(10 citation statements)

References 35 publications

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“…Various studies have evaluated the levels of NK cells in patients with T2DM. 25,26 Our findings are consistent with those of a study that reported a reduction in NK-cell expression. 25 In that study, the level of NK cells was found to be associated with the level of HbA1c.…”

supporting

confidence: 91%

Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia

Allahyani

Alshalawi

Alshalawii

et al. 2023

SMJ

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Objectives: To evaluate the levels of total lymphocytes, B-lymphocytes )CD19+(, T-lymphocytes )CD3+(, natural killer )NK( cells )CD3-/CD56+(, and monocyte subsets in type 2 diabetes mellitus )T2DM( patients in Saudi Arabia. In addition, this study aimed to evaluate whether B-and T-lymphocyte subsets are frequently altered in patients with T2DM. Methods:A case-control study included 95 participants recruited in the study: 62 patients with T2DM and 33 healthy individuals. All the patients were admitted to the Diabetic Centre in Taif, Saudi Arabia. Blood samples were collected between April Original Articleand August 2022. The hemoglobin A1c )HbA1c( level was evaluated in all patients. Flow cytometry was used to measure the expression of B-lymphocyte, T-lymphocyte, NK cells, and monocyte markers. The unpaired t-test was carried out to evaluate the differences in these markers between T2DM patients and healthy individuals.Results: Patients with T2DM were associated with a lower percentage of total lymphocytes, higher percentage of B-lymphocytes, naive, and memory B subsets. In addition, patients with T2DM showed lower percentage of total T-lymphocytes )CD3+( and CD4 T-cells, but higher CD8 T-cell expression. Also, the NK-cell level was reduced in patients with T2DM, and the levels of monocyte subsets were altered. Conclusion:These data suggested that levels of lymphocytes and monocytes are impaired in T2DM patients, and this might be associated with the higher risk of infections observed in these patients.

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supporting

confidence: 91%

Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia

Allahyani

Alshalawi

Alshalawii

et al. 2023

SMJ

View full text Add to dashboard Cite

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“…A recently published meta-analysis, collecting results from 13 independent studies, showed that circulating NK cells number increase in T2D patients (n=491), compared to healthy subjects (n=1607) ( 115 ) ( Figure 2A ) . However, other studies showed no differences in the phenotype between NK cells in T2D and NK cells in healthy controls ( 116 ).…”

Section: Introductionmentioning

confidence: 99%

When a Friend Becomes Your Enemy: Natural Killer Cells in Atherosclerosis and Atherosclerosis-Associated Risk Factors

et al. 2022

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Atherosclerosis (ATS), the change in structure and function of arteries with associated lesion formation and altered blood flow, is the leading cause of cardiovascular disease, the number one killer worldwide. Beyond dyslipidemia, chronic inflammation, together with aberrant phenotype and function of cells of both the innate and adaptive immune system, are now recognized as relevant contributors to atherosclerosis onset and progression. While the role of macrophages and T cells in atherosclerosis has been addressed in several studies, Natural Killer cells (NKs) represent a poorly explored immune cell type, that deserves attention, due to NKs’ emerging contribution to vascular homeostasis. Furthermore, the possibility to re-polarize the immune system has emerged as a relevant tool to design new therapies, with some succesfull exmples in the field of cancer immunotherapy. Thus, a deeper knowledge of NK cell pathophysiology in the context of atherosclerosis and atherosclerosis-associated risk factors could help developing new preventive and treatment strategies, and decipher the complex scenario/history from “the risk factors for atherosclerosis” Here, we review the current knowledge about NK cell phenotype and activities in atherosclerosis and selected atherosclerosis risk factors, namely type-2 diabetes and obesity, and discuss the related NK-cell oriented environmental signals.

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“…The data on human NK cells is somewhat unclear. Meta-analysis of 13 NK cell studies identified 3 with decreased levels/activity, 2 reported elevated levels and 8 of them reported no differences between circulating NK cells in T2D patients and healthy controls ( 52 ).…”

Section: Discussionmentioning

confidence: 99%

A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

et al. 2022

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Type-2 diabetes is a complex disorder that is now considered to have an immune component, with functional impairments in many immune cell types. Type-2 diabetes is often accompanied by comorbid obesity, which is associated with low grade inflammation. However,the immune status in Type-2 diabetes independent of obesity remains unclear. Goto-Kakizaki rats are a non-obese Type-2 diabetes model. The limited evidence available suggests that Goto-Kakizaki rats have a pro-inflammatory immune profile in pancreatic islets. Here we present a detailed overview of the adult Goto-Kakizaki rat immune system. Three converging lines of evidence: fewer pro-inflammatory cells, lower levels of circulating pro-inflammatory cytokines, and a clear downregulation of pro-inflammatory signalling in liver, muscle and adipose tissues indicate a limited pro-inflammatory baseline immune profile outside the pancreas. As Type-2 diabetes is frequently associated with obesity and adipocyte-released inflammatory mediators, the pro-inflammatory milieu seems not due to Type-2 diabetes per se; although this overall reduction of immune markers suggests marked immune dysfunction in Goto-Kakizaki rats.

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Natural killer cell levels in adults living with type 2 diabetes: a systematic review and meta-analysis of clinical studies

Cited by 15 publications

References 35 publications

Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia

Phenotypical evaluation of lymphocytes and monocytes in patients with type 2 diabetes mellitus in Saudi Arabia

When a Friend Becomes Your Enemy: Natural Killer Cells in Atherosclerosis and Atherosclerosis-Associated Risk Factors

A Holistic View of the Goto-Kakizaki Rat Immune System: Decreased Circulating Immune Markers in Non- Obese Type 2 Diabetes

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