Natural killer cells contribute to ‘hot’ tumor regression in the allergic inflammatory environment

Zhou, Ying; Lin, Lin; Zhou, Dongmei; Yu, Zhiwei; Gu, Xiaosong; Ren, Yaning; Liao, Yaping Joyce; Pan, Ruilin; Li, Qingqing; Zhu, Y.; Cui, Yubao

doi:10.1016/j.intimp.2023.110760

Cited by 2 publications

(2 citation statements)

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“…Overall, understanding the genetic factors of childhood asthma and applying them to public health strategies can help prevent the disease and reduce its effects on society and the health care system. 7,8 A case-control study including 572 adolescents with asthma and 590 age-matched healthy controls revealed that the TGFB1 (rs2241715), TLE4 (rs2378383), and MUC22 (rs2523924) genes are associated with childhood asthma risk in the Chinese population. 9 Using Sequenom MassArray technology, a study was conducted on 153 nonasthmatic children and 265 children with asthma, and the results showed that the presence of the T allele of IL33 rs4742170 was linked to an increased risk of fractional exhaled nitric oxide (FeNO) levels at baseline.…”

Section: Introductionmentioning

confidence: 99%

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One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing

Zhou,

Li,

Zhou

et al. 2024

Pediatric Allergy Immunology

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BackgroundPolymorphisms in susceptibility genes are a major risk factor for the development of asthma. Understanding these genetic variants helps elucidate asthma's pathogenesis, predict its onset, expedite antiasthma medication development, and achieve precise targeted individualized treatment. This study developed a test kit based on susceptibility genes for predicting asthma in Chinese children.MethodsThe present study constructed a VariantPro Targeted Library Preparation System with 72 single nucleotide polymorphism (SNP) loci associated with asthma from the ClinVar, OMIM, and SNPedia databases. These SNP loci were detected in the peripheral blood of 499 children with asthma and 500 healthy children. Significant differences were discovered for seven SNP loci. Simultaneously, whole exome sequencing of 46 children with asthma and 50 healthy children identified eight SNP loci with significant differences. The 15 SNP loci identified from Chinese children with asthma were validated in an independent population of 97 children with asthma and 93 healthy children by conducting multiplex polymerase chain reaction (PCR)–next‐generation sequencing genotyping.ResultsFour loci (rs12422149, rs7216389, rs4065275, and rs41453444) were identified, and a single‐tube multifluorescent qPCR (real‐time quantitative PCR) test kit was developed using these four SNP loci. The kit was tested on 269 children with asthma and 724 children with bronchopneumonia.ConclusionsWe identified four loci as susceptibility genes and developed a quantitative PCR test kit for predicting asthma development in Chinese children.

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Section: Introductionmentioning

confidence: 99%

“…Understanding these genetic influences can also help the development of more effective treatment plans. Overall, understanding the genetic factors of childhood asthma and applying them to public health strategies can help prevent the disease and reduce its effects on society and the health care system 7,8 …”

Section: Introductionmentioning

confidence: 99%

One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing

Zhou,

Li,

Zhou

et al. 2024

Pediatric Allergy Immunology

Self Cite

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Atezolizumab, bevacizumab, pemetrexed and platinum for EGFR‐mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis

Wu,

Ho,

Yang

et al. 2024

Clinical & Translational Med

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BackgroundAcquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) remains a significant hurdle for patients with EGFR‐mutated non‐small cell lung cancer (NSCLC), particularly those lacking the EGFRT790M. IMpower 150 study demonstrated promising efficacy for a combination of immune‐chemotherapy and bevacizumab in patients with EGFR‐mutated NSCLC.MethodsThis open‐label, single‐arm, phase II trial evaluated the efficacy and immune cell profile of the modified regimen combining atezolizumab, bevacizumab (7.5 mg/kg) and chemotherapy in patients with EGFR‐mutated NSCLC following TKI failure. The primary endpoint was objective response rate (ORR). The re‐biopsy tissue specimens and serial peripheral blood samples were collected to analyse the immune cell profile and tumour microenvironments.Rresults22 EGFR‐mutant NSCLC patients participated in this study. The ORR was 42.9%, with a disease control rate (DCR) of 100%. Median progression‐free survival (PFS) was 6.3 months. Patients with programmed death‐ligand 1 (PD‐L1) expression ≥1% exhibited significantly higher ORR (75 vs. 23.1%; p = .032) and longer PFS (14.0 vs. 6.1 months; p = .022) compared with those with PD‐L1 expression < 1%. Grade ≥ 3 adverse events occurred in 40.9% of patients. Higher peritumour nature killer (NK) cell infiltration and lower peripheral helper T cell counts before treatment were associated with favourable ORR and longer PFS, respectively. After disease progression, the proportion of S100A9+ myelod‐derived suppressor cells (MDSCs) increased, while regulatory T cells decreased.ConclusionThis modified combination regimen may be a promising therapeutic option for EGFR‐mutant NSCLC patients with TKI resistance, especially those with PD‐L1‐positive tumours. Furthermore, immune cell profiling may aid in identifying patients who may benefit from this approach.Key points The combination regimen yielded promising efficacy in NSCLC patients after EGFR‐TKI resistance, particularly those with PD‐L1‐positive tumours. Higher peritumour NK cell and lower peripheral helper T cell were associated with favourable ORR and longer PFS, respectively. After disease progression, the proportion of S100A9+ MDSC increased, but Treg cells decreased.

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Natural killer cells contribute to ‘hot’ tumor regression in the allergic inflammatory environment

Cited by 2 publications

References 39 publications

One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing

One panel with four single nucleotide polymorphisms for Chinese children with asthma: Integrating public data and whole exome sequencing

Atezolizumab, bevacizumab, pemetrexed and platinum for EGFR‐mutant NSCLC patients after EGFR TKI failure: A phase II study with immune cell profile analysis

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