Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype

Pridgeon, Chris S.; Lennon, Greig P.; Pazmany, Laszlo; Thompson, R. N.; Christmas, Stephen E.; Moots, R. J.

doi:10.1093/rheumatology/keg240

Cited by 88 publications

(84 citation statements)

References 43 publications

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“…NK cells are considered pathogenic elements in the development of the disease (34,35). The proportions of CD56 bright and CD56 dim NK cells in the peripheral blood of RA patients are similar to those in healthy subjects (36)(37)(38)(39). The same observation was made for type 1 diabetes patients, with no significant difference compared with healthy controls (40,41).…”

Section: Cd56supporting

confidence: 53%

Human CD56bright NK Cells: An Update

Michel

Poli

Cuapio

et al. 2016

The Journal of Immunology

326

273

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Human NK cells can be subdivided into various subsets based on the relative expression of CD16 and CD56. In particular, CD56brightCD16−/dim NK cells are the focus of interest. They are considered efficient cytokine producers endowed with immunoregulatory properties, but they can also become cytotoxic upon appropriate activation. These cells were shown to play a role in different disease states, such as cancer, autoimmunity, neuroinflammation, and infection. Although their phenotype and functional properties are well known and have been extensively studied, their lineage relationship with other NK cell subsets is not fully defined, nor is their precise hematopoietic origin. In this article, we summarize recent studies about CD56bright NK cells in health and disease and briefly discuss the current controversies surrounding them.

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Section: Cd56supporting

confidence: 53%

Human CD56bright NK Cells: An Update

Michel

Poli

Cuapio

et al. 2016

The Journal of Immunology

326

273

View full text Add to dashboard Cite

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“…Thus, CD56 bright NK cells are highly enriched and activated within synovial fluid from patients with psoriatic arthritis and rheumatoid arthritis (RA),122, 123 as well as in inflamed tissues in tuberculosis 124. Similarly, MAIT cells are also well established to be recruited to sites of inflammation,81, 125 and have been found to be enriched in the synovial fluid of patients with ankylosing spondylitis126 and RA127.…”

Section: Functional Similarities Between Nk Cell and Cd8+ T‐cell Subsetsmentioning

confidence: 99%

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes

2018

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SummaryNew data in the worlds of both innate‐like CD8+ T‐cells and natural killer (NK) cells have, in parallel, clarified some of the phenotypes of these cells and also their associated functions. While these cells are typically viewed entirely separately, the emerging innate functions of T‐cells and, similarly, the adaptive functions of NK cells suggest that many behaviours can be considered in parallel. In this review we compare the innate functions of CD8+ T‐cells (especially mucosal‐associated invariant T‐cells) and those of NK cells, and how these relate to expression of phenotypic markers, especially CD161 and CD56.

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“…Several reports have shown increased CD56 bright to CD56 dim NK cell ratios at sites of chronic inflammation, including cancer (7)(8)(9)(10)(11)(12). Activated granulocytes, associated with chronic inflammation, have been shown to suppress T and NK cell function and viability as well as the expression of NKRs (20 -23).…”

Section: Cd56 Dim Nk Cells Selectively Undergo Cell Death When Exposementioning

confidence: 99%

“…There have been several reports of an increased ratio of CD56 bright to CD56 dim NK cells at sites of chronic inflammation, such as rheumatoid arthritis, tuberculosis, and pulmonary sarcoidosis (7)(8)(9)(10)(11)(12). It is not clear whether this is due to increased recruitment, proliferation, or generation of CD56 bright cells or due to preferential death of CD56 dim cells.…”

mentioning

confidence: 99%

The CD16−CD56bright NK Cell Subset Is Resistant to Reactive Oxygen Species Produced by Activated Granulocytes and Has Higher Antioxidative Capacity Than the CD16+CD56dim Subset

Harlin

Hanson

Johansson

et al. 2007

The Journal of Immunology

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Human NK cells can be divided into CD56dim and CD56bright subsets. These two types of NK cells respond to different types of stimuli, with CD56dim NK cells having direct cytotoxic ability and CD56bright NK cells having mainly an immunoregulatory function. We show that the CD16+CD56dim NK subset is characterized by sensitivity to cell death induced by activated granulocytes. We identified hydrogen peroxide (H2O2) as the major effector molecule responsible for the cytotoxic effect of granulocytes on CD56dim NK cells, because the ability of granulocytes to kill CD56dim NK cells was completely abrogated in the presence of the hydrogen peroxide scavenger catalase. When exposing NK cells to H2O2, CD56dim cells showed rapid mitochondrial depolarization and down-regulation of activating NKRs, eventually resulting in cell death, whereas CD56bright cells remained unaffected. The difference in sensitivity to H2O2 was mirrored by a difference in intracellular oxidation levels between CD56dim and CD56bright NK cells, and cell lysates from the latter subset possessed a greater ability to block H2O2-mediated oxidation. Our data may explain the preferential accumulation of CD56bright NK cells often seen in environments rich in reactive oxygen species, such as at sites of chronic inflammation and in tumors.

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Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype

Abstract: We identified a novel phenotype of SF NK cells that is of potential significance in RA. Experiments are now under way to determine the function of these SF NK cells and their potential role in RA.

Cited by 88 publications

References 43 publications

Human CD56bright NK Cells: An Update

Human CD56bright NK Cells: An Update

Innate‐like CD8+ T‐cells and NK cells: converging functions and phenotypes

The CD16−CD56bright NK Cell Subset Is Resistant to Reactive Oxygen Species Produced by Activated Granulocytes and Has Higher Antioxidative Capacity Than the CD16+CD56dim Subset

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