Natural Killer/T-Cell Lymphoma Invading the Orbit and Globe

Lyons, Lance J.; Vrcek, Ivan; Somogyi, Marie; Taheri, Kevin; Admirand, Joan H.; Chexal, Saradha; Loukas, Demetrius; Nakra, Tanuj

doi:10.1080/08998280.2017.11930224

Cited by 10 publications

(4 citation statements)

References 15 publications

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“…4A). 7,9,21–86 Table 1 summarizes the patients’ demographic characteristics. Table 2 summarizes the patients’ presenting clinical characteristics.…”

Section: Resultsmentioning

confidence: 99%

“…Primary or secondary orbital NK/T-cell lymphoma has been reported as a rare occurrence. 7,8 Patients with orbital involvement may present with visual symptoms or symptoms due to involvement of the tear duct system or other adnexal structures. 9 Here, we describe a case of a recurrent NK/T-cell lymphoma, which presented as a rapidly growing, superinfected mass of the nasal sinuses with orbital extension.…”

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confidence: 99%

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NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature

Dhodapkar

Spadaro

Heng

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To present the clinical course of a patient with recurrent NK/T-cell lymphoma (NKTL) involving the orbit and to review the literature on patients with NKTL involving the orbit. Methods: The PubMed database was searched for all cases of NKTL involving orbital, intraocular, or adnexal ocular structures. Results: Ninety-six patients were included in the final analysis. The mean age of diagnosis was 48.1 ± 16.8 years. The patients were 53/96 (55.2%) male and 43/96 (44.8%) female. Tumor location varied and included the orbit in 80/96 (83.3%), nasosinus in 56/96 (58.3%), uvea in 11/96 (11.5%), lacrimal gland in 9/96 (9.4%), lacrimal drainage system in 11/96 (11.5%), and conjunctiva in 7/96 (7.3%) cases. Management included surgical debulking in 29/96 (30.2%) cases, radiotherapy in 52/96 (54.2%) cases, and chemotherapy in 82/96 (85.4%) cases. Median survival was 6 months (95% CI: 5–9). Chemotherapy (hazard ratio = 0.80, 95% CI: 0.67–0.95, p = 0.013), radiotherapy (hazard ratio = 0.75, 95% CI: 0.64–0.87, p < 0.001), and orbital involvement being a recurrence of disease (hazard ratio = 0.79, 95% CI: 0.67–0.95, p = 0.009) were associated with improved survival. Advanced Ann Arbor stage (III–IV) at diagnosis (hazard ratio = 1.22, 95% CI: 1.08–1.38, p = 0.001), vision loss (hazard ratio = 1.18, 95% CI: 1.04–1.34, p = 0.009), proptosis (hazard ratio = 1.15, 95% CI: 1.01–1.30, p = 0.035) and periorbital swelling (hazard ratio = 1.15, 95% CI: 1.00–1.33, p = 0.048) were associated with poor survival. Conclusions: NK/T-cell lymphoma involving the orbit, globe, or ocular adnexa heralds a poor prognosis where early diagnosis and therapy are critical. The use of radiotherapy and chemotherapy is associated with improved survival.

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“…4A). 7,9,21–86 Table 1 summarizes the patients’ demographic characteristics. Table 2 summarizes the patients’ presenting clinical characteristics.…”

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature

Dhodapkar

Spadaro

Heng

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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“…A few cases of oculartissue ENKTL have also been reported, including primary orbital and intraocular ENKTL or invasion of primary nasal lesions with cerebrospinal fluid, meningeal, periorbital involvement, but there have been no reports of nasal NK/T-cell lymphoma that had expanded to ocular tissue along with lung and mediastinal and axillary lymph involvement. [20][21][22][23] Diverse ocular complications in NK/T-cell lymphoma have been reported in the literature, such as anterior uveitis, vitritis, rhegmatogenous/non-rhegmatogenous retinal detachment. [24][25][26][27][28][29] To the best of our knowledge, this is the first report of a case with simultaneous ocular, lung, mediastinal and axillary lymph involvement.…”

Section: Discussionmentioning

confidence: 99%

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Wang

Jia

Zhang

et al. 2022

European Journal of Ophthalmology

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Background To report a rare case of nasal natural killer/T (NK/T) cell lymphoma with bilateral intraocular and lung metastasis and to further describe the clinical features of intraocular manifestations. Case presentation A 54-year-old man presented with a 3-month history of left nasal congestion, and bilateral vision impairment of one week duration. Subsequent maxillary computed tomography (CT) and multiple biopsies confirmed the diagnosis of nasal NK/T-cell lymphoma. EBV-encoded small RNA (EBER) in situ hybridization revealed EBV infection. A comprehensive ophthalmic examination found lymphoma-associated retinopathy and choroidopathy, which presented as bilateral diverse patterns and retinal detachment. In addition, the chest CT showed multiple scattered nodules in both lungs, and soft-tissue mass in the left hilum with mediastinal and axillary lymphadenopathy. The condition of this patient deteriorated rapidly and he died shortly after diagnosis. Conclusions The rarity of secondary ocular NK/T-cell lymphoma makes it challenging to identify these tumors early. Both otolaryngologist and ophthalmologists should be aware of ocular involvement and other secondary manifestations of NK/T-cell lymphoma.

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“…To the best of our In concurrent lesions, a biopsy of the orbital tumor is preferable for establishing an accurate diagnosis. 36,37 Since no cytology was obtained from the AC in the reported patient, the presence of intraocular lymphoma can only be presumed.…”

Section: Concurrent Ocular Adnexal Lymphoma and Intraocular Lymphomamentioning

confidence: 97%

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

Rafizadeh,

Ghahvehchian,

Rajabi

et al. 2023

Ophthalmic Plastic &Amp; Reconstructive Surgery

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Purpose: To review the existing literature on patients with anaplastic large cell lymphoma (ALCL) affecting the globe and/or ocular adnexa, and to present a report documenting the clinical course of a patient with ALCL that involved their globe and ocular adnexa. Methods: PubMed, Scopus, and Google scholar were systematically searched for all cases of ALCL involving intraocular or adnexal ocular structures from inception to May 2023. Moreover, a new reported case added to the cases found in searches. Results: The review identified 1680 studies, with 8 meeting inclusion criteria. A total of 9 patients were included with a mean age of 29.7 years (median: 30.0, range: 1.3–48). Primary ALCL was present in 5/9 (55.6%) patients. The most common ophthalmic manifestations included periorbital swelling (5/8), chemosis (5.8), and decreased vision (5/7). Misdiagnoses were initially made in 3 patients, and the lag time to correct diagnosis from 3 weeks to 3 months. CD30 expression was positive in all cases, and 6/9 patients were positive for anaplastic lymphoma kinase, resulting in 6/9 patients being diagnosed with anaplastic lymphoma kinase-positive ALCL. In terms of management modalities, chemotherapy was administered in 8/9 patients, while radiation therapy was utilized in 4/9 patients, and 2 underwent autologous stem cell transplantation. Five (55.6%) patients succumbed to ALCL while 4 (44.4%) were alive and disease-free at the last follow-up. The median times from the initial presentation of ALCL to death, ophthalmic presentation to death, and diagnosis to death were 4.12 months (range: 1.1–168.0), 2.62 months (range: 1.1–144), and 4.00 months (range: 0.10–168), respectively. The median follow-up duration was 21.0 months (range: 1.1–168.0). Conclusions: ALCL involving the globe and ocular adnexa is a rare and highly malignant tumor that can mimic benign clinical conditions. Early biopsy and aggressive treatment with chemotherapy regimens such as CHOP and radiation therapy may be useful.

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Natural Killer/T-Cell Lymphoma Invading the Orbit and Globe

Cited by 10 publications

References 15 publications

NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature

NK/T-cell Lymphoma With Orbital Involvement: A Case Report and Systematic Review of the Literature

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Anaplastic Large Cell Lymphoma With Intraocular or Ocular Adnexal Involvement: A Case Report and Systematic Review

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