The act of will and the action of the body are not two different states…; they do not stand in the relation of cause and effect but are one and the same thing…. The action of the body is nothing but the act of will …. translated into perception. -Arthur Schopenhauer, 1819 1 Our social world is an ever-changing milieu in which boundless verbal and nonverbal signals are generated by fellow humans. To ensure our survival, we must perceive certain regularities from the complexity that surrounds us. A failure to meet this daily challenge may prove costly for some; social encounters trigger several psychiatric symptoms, while social withdrawal reduces their intensity, at least temporarily. 2 For example, disorganization (or formal thought disorder), one of the central features of schizophrenia, presents primarily as a disruption in cooperative communication that occurs in a social context. Though many technical advances now allow us to study "socially" interacting agents in the laboratory (for example, see Kingsbury and colleagues 3 ), psychiatric symptoms are rarely studied in the context of neural mechanisms of social encounters. To tackle this challenge, we need empirical tools to study the dynamic neural framework of social interaction, starting from a 2-person perspective. In this editorial, we first present such a tool: an emerging "active inference" perspective of cooperative communication between 2 individuals. We then introduce the 2-brain problem of formal thought disorder in schizophrenia as an exemplar case of its utility and map resulting theoretical expectations to known signs of this construct. Lastly, we highlight several experimental opportunities that arise from casting of formal thought disorder in the active inference framework.