Natural Lipid Nanoparticles Containing Nimesulide: Synthesis, Characterization and &lt;I&gt;In Vivo&lt;/I&gt; Antiedematogenic and Antinociceptive Activities

Raffin, Renata P.; Lima, Amanda Barroso; Lorenzoni, Ricardo; Antonow, Michelli Barcelos; Turra, Cláudia; Alves, Marta Palma; Fagan, Solange B.

doi:10.1166/jbn.2012.1377

Cited by 28 publications

(12 citation statements)

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“…Good DDSs can enhance biodistribution and direct the drug to the location where it should act. Moreover, DDSs can provide long-term release of the pharmacotherapeutic at the target location and reduce its undesirable side effects [1][2][3]. Thus, beneficial DDSs are those that spend enough time in the blood stream and are tailored to the desired tissue.…”

Section: Introductionmentioning

confidence: 99%

Interaction study between maltose-modified PPI dendrimers and lipidic model membranes

Wrobel

Appelhans

Signorelli

et al. 2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

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The influence of maltose-modified poly(propylene imine) (PPI) dendrimers on dimyristoylphosphatidylcholine (DMPC) or dimyristoylphosphatidylcholine/dimyristoylphosphatidylglycerol (DMPC/DMPG) (3%) liposomes was studied. Fourth generation (G4) PPI dendrimers with primary amino surface groups were partially (open shell glycodendrimers - OS) or completely (dense shell glycodendrimers - DS) modified with maltose residues. As a model membrane, two types of 100nm diameter liposomes were used to observe differences in the interactions between neutral DMPC and negatively charged DMPC/DMPG bilayers. Interactions were studied using fluorescence spectroscopy to evaluate the membrane fluidity of both the hydrophobic and hydrophilic parts of the lipid bilayer and using differential scanning calorimetry to investigate thermodynamic parameter changes. Pulsed-filed gradient NMR experiments were carried out to evaluate common diffusion coefficient of DMPG and DS PPI in D2O when using below critical micelle concentration of DMPG. Both OS and DS PPI G4 dendrimers show interactions with liposomes. Neutral DS dendrimers exhibit stronger changes in membrane fluidity compared to OS dendrimers. The bilayer structure seems more rigid in the case of anionic DMPC/DMPG liposomes in comparison to pure and neutral DMPC liposomes. Generally, interactions of dendrimers with anionic DMPC/DMPG and neutral DMPC liposomes were at the same level. Higher concentrations of positively charged OS dendrimers induced the aggregation process with negatively charged liposomes. For all types of experiments, the presence of NaCl decreased the strength of the interactions between glycodendrimers and liposomes. Based on NMR diffusion experiments we suggest that apart from electrostatic interactions for OS PPI hydrogen bonds play a major role in maltose-modified PPI dendrimer interactions with anionic and neutral model membranes where a contact surface is needed for undergoing multiple H-bond interactions between maltose shell of glycodendrimers and surface membrane of liposome.

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Section: Introductionmentioning

confidence: 99%

Interaction study between maltose-modified PPI dendrimers and lipidic model membranes

Wrobel

Appelhans

Signorelli

et al. 2015

Biochimica et Biophysica Acta (BBA) - Biomembranes

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“…[30][31][32][33][34][35][36][37][38] Elucidation of actual structural features of such small assemblies, especially smaller than 100 nm and more specifically in the sub-10 nm scales, has been possible (to some extent) by development of analytical tools for extracting geometrical signatures from indirect data measurements (e.g., molecular diffraction patterns 7 27 and application of techniques such as fluorescence resonance energy transfer 39 ). In general, pattern generation and recognition in 3-D space have been of wide interest in the area of molecular structures.…”

Section: Discussionmentioning

confidence: 99%

Extracting Signatures of Spatial Organization for Biomolecular Nanostructures

Mittal¹,

Acharya²

2012

j nanosci nanotechnol

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Considering that a variety of biomolecular structures are in size scales much smaller than 100 nm, analytical tools for extracting geometrical signatures from data obtained by indirect measurements are essential for obtaining accurate structural information. Insights into the underlying geometrical origins of constituents of diverse systems in 3-Dimensional (3-D) space have formed the foundations for tools leading to elucidation of chemical and biomolecular structures. In this work, we develop a geometrical tool that transforms arrangement of apparently randomly positioned points in 3-D space into 2-D maps. This allows extraction of signatures of spatial organization and geometrical origins of the points in 3-D space. To test the geometrical tool, we analyze 13550 crystal structures of naturally occurring folded proteins. We report extraction of signatures of a universal spatial organization of backbones of folded proteins. We also report the remarkable finding that the "globular" shape of soluble proteins is ellipsoidal rather than spherical.

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“…Nonsteroidal anti-inflammatory drugs have also been demonstrated as an analgesic and anti-inflammatory agent; however, they have been reported to be related with several interactions with other medications and thereby causing serious toxic effects to the body systems [9]. Several nano-formulations have been successfully demonstrated in preclinical studies [10][11][12][13] to improve the efficacy and decrease the toxicity of NSAIDs by targeted delivery to the site of inflammatory pain. Dong et al reported that celecoxib-loaded liposomes encapsulated in hyaluronate gel was more potent than either single agent in pain control and cartilage protection in a rabbit knee osteoarthritis model after intra-articular injection [14].…”

Section: Application Of Liposomes In Pain Therapymentioning

confidence: 99%

Nanotechnology application for pain therapy

Moradkhani

Karimi

Negahdari

2017

Artificial Cells, Nanomedicine, and Biotechnology

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Prolonged delivery of analgesic drugs at target sites remains a critical issue for efficient pain management. The use of nano-carriers has been reported to facilitate applicable delivery of these agents to target sites with a reduced level of systemic toxicity. Different analgesics have been loaded onto various nano carriers, including those that are natural, synthetic and copolymer, for various medical applications. In this review, we will discuss the concept of nano-formulated carriers for analgesic drugs and their impacts on the field of pain management.

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Natural Lipid Nanoparticles Containing Nimesulide: Synthesis, Characterization and <I>In Vivo</I> Antiedematogenic and Antinociceptive Activities

Cited by 28 publications

References 0 publications

Interaction study between maltose-modified PPI dendrimers and lipidic model membranes

Interaction study between maltose-modified PPI dendrimers and lipidic model membranes

Extracting Signatures of Spatial Organization for Biomolecular Nanostructures

Nanotechnology application for pain therapy

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