Natural Magnolol ameliorates coccidiosis infected with Eimeria tenella by affecting antioxidant, anti-inflammatory, and gut microbiota of chicks

Mo, Jiahao; Xiang, Jun; Jiang, Li; Meng, Yunxiao; Zhang, Zhidan; Zhang, Lifang; Zhang, Geyin; Yang, Yunqiao; Liu, Gengsong; Lu, Yujie; Hu, Dandan; Si, Hongbin

doi:10.1016/j.psj.2023.102975

Cited by 7 publications

(1 citation statement)

References 54 publications

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“…12 Additionally, recent preclinical studies have highlighted Magnolol's potential in exhibiting antioxidant and antimicrobial properties with minimal toxicity, making it an intriguing candidate for the treatment and prevention of gastric ulcers. 13,14 This interest is further driven by the significant role oxidative stress, particularly through excessive production of ROS, plays in the pathogenesis of gastric ulcers induced by EtOH.…”

Section: ■ Introductionmentioning

confidence: 99%

Construction of Magnolol Nanoparticles for Alleviation of Ethanol-Induced Acute Gastric Injury

Li,

Zhu,

Chen

et al. 2024

J. Agric. Food Chem.

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Ethanol (EtOH) has been identified as a potential pathogenic factor in gastric ulcer development primarily due to its association with gastric injury and excessive production of reactive oxygen species. Magnolol (Mag), the principal active compound in Magnolia officinalis extract, is well studied for its notable anti-inflammatory and antioxidant properties. However, its limited solubility, propensity for agglomeration, and low absorption and utilization rates significantly restrict its therapeutic use. This study aims to overcome these challenges by developing a Mag nanoparticle system targeting the treatment and prevention of EtOHinduced gastric ulcers in mice. Utilizing a click chemistry approach, we successfully synthesized this system by reacting thiolated bovine serum albumin (BSA•SH) with Mag. The in vitro analysis revealed effective uptake of the BSA•SH-Mag nanoparticle system by human gastric epithelial cells (GES-1), showcasing its antioxidant and anti-inflammatory capabilities. Additionally, BSA•SH-Mag exhibited gradual disintegration and release in simulated gastric fluid, resulting in a notable reduction of oxidative stress in gastric tissues and mucosal tissue repair and effectively reducing inflammatory expression. Furthermore, BSA•SH-Mag attenuated EtOHinduced gastric inflammation by decreasing the level of NOX4 protein expression and augmenting the level of Nrf2 protein expression. In conclusion, our findings indicate that BSA•SH-Mag represents a promising candidate as an oral therapeutic for gastric ulcer treatment.

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Section: ■ Introductionmentioning

confidence: 99%

Construction of Magnolol Nanoparticles for Alleviation of Ethanol-Induced Acute Gastric Injury

Li,

Zhu,

Chen

et al. 2024

J. Agric. Food Chem.

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Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Chen,

Liu,

Yue

et al. 2024

Animal Research and One Health

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The intestinal tract is the main place for animals to digest food and absorb nutrients, which also serves as the first line of defense against pathogens that invade the internal environment. Therefore, normal intestinal structure and function are essential for animal health. Poultry coccidiosis is an intestinal disease primarily caused by the parasitization of intestinal epithelial cells by protozoa of the genus Eimeria. The occurrence of coccidiosis not only compromises the intestinal integrity of poultry but also increases their disease susceptibility, thus posing a serious threat to the overall health and productivity of poultry. Nowadays, the primary methods for controlling and preventing coccidiosis in poultry are anticoccidial drugs or live oocyst vaccines. However, the use of the former may be associated with problems of resistance and drug residues, while the use of the latter may cause intestinal damage and significantly increase farming costs. For these reasons, it is critical to investigate green, safe, and cost‐effective natural alternative strategies such as phytochemicals and probiotics for controlling coccidiosis as well as mitigating the deleterious effects of coccidial infections in production. In this review, we aim to summarize the role, mechanisms, and therapeutic potential of natural products in the treatment of coccidiosis to lay a theoretical foundation for effective coccidiosis control.

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Bacillus subtilis JATP3 improved the immunity of weaned piglets by improving intestinal flora and producing citalopram

He,

Jin,

et al. 2024

Microbial Pathogenesis

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Natural Magnolol ameliorates coccidiosis infected with Eimeria tenella by affecting antioxidant, anti-inflammatory, and gut microbiota of chicks

Cited by 7 publications

References 54 publications

Construction of Magnolol Nanoparticles for Alleviation of Ethanol-Induced Acute Gastric Injury

Construction of Magnolol Nanoparticles for Alleviation of Ethanol-Induced Acute Gastric Injury

Plants, plant‐derived compounds, probiotics, and postbiotics as green agents to fight against poultry coccidiosis: A review

Bacillus subtilis JATP3 improved the immunity of weaned piglets by improving intestinal flora and producing citalopram

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