Natural medicine combined with nanobased topical delivery systems: a new strategy to treat psoriasis

Abstract

Psoriasis, an autoimmune inflammatory skin disorder, is one of the commonest immune-mediated disease conditions affecting individuals globally. At the moment, the conventional methods applied against psoriasis treatment have various drawbacks involving limited efficacy, skin irritation, immunosuppression, etc. Therefore, it is important for scientists to find a more potent and alternative drug approach towards psoriasis therapeutics. Natural medicine still remains an important source for new drug discovery due to its therapeutical significance in various drug administration routes. However, the traditional formulation of topical therapies for psoriasis is limited in efficacy, which limits the use of natural medicine. Based on the aforementioned limitations, the use of nanocarriers in preparation of these topical herbal products could be tremendously beneficial in enhancing the efficacy of topical medications. Growing pieces of evidence have proposed that the utilization of nanocarriers in transdermal preparation as a prospective technique, with regards to better potency, directs drug absorption to site of action, and minimum toxicity effect respectively. In the course of this review, we emphasized the pathological mechanism of psoriasis, natural medicine formula, active components of natural medicine, and nanopreparations used in the treatment of psoriasis.

Sulforaphane alleviates psoriasis by enhancing antioxidant defense through KEAP1-NRF2 Pathway activation and attenuating inflammatory signaling

“…Bioactive compounds found in nature have great potential for treating diseases and may be safer in than synthetic agents [30,31]. SFN is a natural isothiocyanate compound derived from plants, mainly from cruciferous vegetables such as cabbage, broccoli, cauli ower, and hugger kale, with a promising biosafety pro le [32].…”

Advance and Challenges in the Treatment of Skin Diseases with the Transdermal Drug Delivery System

“…Niosomes constitute a useful carrier for TDDS therapy for skin conditions since non-ionic surfactants are reasonably inexpensive and show great biocompatibility with the epidermis [ 100 ]. Niosomes are considered to have two roles for increasing the efficiency of drug penetration: (1) Extending the amount of time that drugs are retained in the stratum corneum, increasing the concentration gradient caused by drug accumulation, and enhancing passive transport; and (2) acting directly on the stratum corneum, loosening its structure and decreasing resistance to drug penetration [ 101 ].…”