“…SCN1A, SCN2A, SCN3A, and SCN8A genes which individually encode voltagegated sodium channels, that is Na V 1.1, Na V 1.2, Na V 1.3, and Na V 1.6, are related to early onset epilepsies (Brunklaus et al, 2020). Other mutations in ion channels, such as KCNMA1, KCNQ2, KCNT1, KCNQ3, CACNA1A, CLCN2, and HCN1-4, affect the transportation of potassium, calcium, chloride, and cyclic nucleotide (He et al, 2021). Inflammation is the cause and the consequence of seizure, becoming a vicious circle and leading epilepsy to develop and deteriorate (Vezzani et al, 2011).…”