Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects

Patel, DK; Kumar, Rajesh; Laloo, Damiki; Hemalatha, S

doi:10.1016/s2222-1808(12)60054-1

Cited by 180 publications

(119 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…From these findings, Thymus species may be valuable to control postprandial hyperglycaemia for type 2 diabetes management. Again, several Lamiaceae species were reported as strong anti-diabetic agents in in vivo and in vitro studies 70,71 .…”

Section: A-amylase and A-glucosidase Inhibitionmentioning

confidence: 99%

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

Ceylan

Zengin

Uysal

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

We investigated the antioxidant and enzyme inhibitory activities and chemical composition of the hydro-distilled essential oil (0.35% yield) from aerial parts of Thymus spathulifolius. Antioxidant capacity of the oil was assessed by different methods including free radical scavenging (DPPH and ABTS), reducing power (FRAP and CUPRAC) and phosphomolybdenum assay. Inhibitory activities were analyzed against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), a-amylase, a-glucosidase, and tyrosinase. Twenty-one constituents were identified representing 97.2% of the total oil with thymol (50.5%), borneol (16.7%) and carvacrol (7.7%) as the major components. The essential oil exhibited good antioxidant activity with IC 50 values of 3.82 and 0.22 mg/mL determined by free radical scavenging DPPH and ABTS, respectively. EC 50 values of FRAP and CUPRAC were found to be 0.12 and 0.34 mg/mL, respectively. The results of the present study support the uses of T. spathulifolius essential oil as a source of natural antioxidants and bioactivities for functional foods and phytomedicines.

show abstract

Section: A-amylase and A-glucosidase Inhibitionmentioning

confidence: 99%

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

Ceylan

Zengin

Uysal

et al. 2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

show abstract

“…Menurut Dalimartha (2003), daun Bungur memiliki kandungan senyawa fenolik seperti flavonoid dan tanin. Senyawa-senyawa fenolik menurut Patel et al (2012) memiliki aktivitas antihiperglikemik. Senyawa fenolik seperti flavonoid juga merupakan salah satu agen antioksidan alami (Shan et al, 2005).…”

Section: Pendahuluanunclassified

Antioxidant Activity Study And Α-glucosidase Inhibitor Phenolic Leaf Extract Bungur (Lagerstroemia speciosa) From Meru National Park Betiri

Rochman

Siswoyo²,

Ratnadewi³

2017

J. I. Dasar

View full text Add to dashboard Cite

Study activities phenolic extract of bungur leaf as an antioxidant and inhibitor for the enzyme α-glucosidase was performed by spectrophotometric method. The extraction was carried out by three solvents with different polarity level in order to get three types of extracts namely hexane extract Bungur (HB), ethyl acetate extract Bungur (EAB), and the methanol extract Bungur (MB). The units, used in the analysis, is the total phenolic that standardized in gallic acid. The antioxidant activity of phenolic extracts Bungur leaf can be seen from its ability to reduce free radicals through the damping test DPPH radical, superoxide anion, and hydroxyl. Potential extract phenolic leaf Bungur as an inhibitor of α-glucosidase were analyzed by inhibition of α-glucosidase, but in this study also tested the inhibition of the enzyme α-amylase because both of these enzymes worked on the digestive system and hydrolyze carbohydrates. The results generally showed that the methanol extract of leaves Bungur potential as antioxidants that compared with standard vitamin C. In addition, it had as well as potential for inhibitors of α-glucosidase and α-amylase that compared akarbosa standard, which is expected to be a natural antidiabetic agent.

show abstract

“…In these, the caloric distribution for type 2 DM as follows: 10-15% from protein, 20-25% from fats and 55-60% energy from carbohydrate. For treating Type 2 DM, the drugs can be divided into three categories [18] :…”

Section: Management Of Type 2 Dmmentioning

confidence: 99%

Herbal Drugs Used in the Treatment of Diabetes: An Overview

Neeta¹

2017

WJPPS

View full text Add to dashboard Cite

show abstract

Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects

Cited by 180 publications

References 42 publications

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

GC-MS analysis and in vitro antioxidant and enzyme inhibitory activities of essential oil from aerial parts of endemic Thymus spathulifolius Hausskn. et Velen

Antioxidant Activity Study And Α-glucosidase Inhibitor Phenolic Leaf Extract Bungur (Lagerstroemia speciosa) From Meru National Park Betiri

Herbal Drugs Used in the Treatment of Diabetes: An Overview

Contact Info

Product

Resources

About