Natural Metal Polyphenol Nanozyme: Free Radical Scavenging and Antioxidation for the Treatment of Acute Kidney Injury

Yuan, Haitao; Wang, Fujing; Wang, Zhen; Gu, Di; Huang, Wei; Fu, Chunjin; Wang, Xiaoxian; Ma, Jingbo; Li, Zhijie; Dai, Lingyun; Zhang, Xinzhou; Xiao, Wei; Wang, Jigang

doi:10.1021/acsmaterialslett.3c00906

Cited by 13 publications

(1 citation statement)

References 39 publications

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“…As a byproduct of the paper industry, lignin is economical and nontoxic, making it suitable for biomedical applications with superior ROS-scavenging abilities. Furthermore, similar to nanozyme complexes formed through metal ions and phenolic ligands chelation reactions, 68 ligninbased hydrogel patches also offer broad-spectrum ROS neutralization, which makes them highly effective and convenient for large-scale tissue applications.…”

Section: Anti-inflammatory Properties Of Lignin Hydrogels Under H 2 O...mentioning

confidence: 99%

Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin

Trinh,

Nguyen,

Kim

2024

ACS Appl. Mater. Interfaces

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Atopic dermatitis (AD), a chronic skin condition characterized by itching, redness, and inflammation, is closely associated with heightened levels of endogenous reactive oxygen species (ROS) in the skin. ROS can contribute to the onset and progression of AD through oxidative stress, which leads to the release of proinflammatory cytokines, T-cell differentiation, and the exacerbation of skin symptoms. In this study, we aim to develop a therapeutic antioxidant hydrogel patch for the potential treatment of AD using lignin, a biomass waste material. Lignin contains polyphenol groups that enable it to scavenge ROS and exhibit antioxidant properties. The lignin hydrogel patches, possessing optimized mechanical properties through the control of the lignin and cross-linker ratio, demonstrated high ROS-scavenging capabilities. Furthermore, the lignin hydrogel demonstrated excellent biocompatibility with the skin, exhibiting beneficial properties in protecting human keratinocytes under high oxidative conditions. When applied to an AD mouse model, the hydrogel patch effectively reduced epidermal thickness in inflamed regions, decreased mast cell infiltration, and regulated inflammatory cytokine levels. These findings collectively suggest that lignin serves as a therapeutic hydrogel patch for managing AD by modulating oxidative stress through its ROS-scavenging ability.

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Section: Anti-inflammatory Properties Of Lignin Hydrogels Under H 2 O...mentioning

confidence: 99%

Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin

Trinh,

Nguyen,

Kim

2024

ACS Appl. Mater. Interfaces

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Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Dong,

Wang,

Chen

et al. 2024

Adv Healthcare Materials

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Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving the ROS‐induced toxicity therapy mediated by ROS producers and antioxidant therapy by ROS scavengers. Nanotechnology advancements have led to the development of numerous nanomaterials with ROS‐modulating capabilities, among which carbon dots (CDs) standing out as noteworthy ROS‐modulating nanomedicines own their distinctive physicochemical properties, high stability, and excellent biocompatibility. Despite progress in treating ROS‐related diseases based on CDs, critical issues such as rational design principles for their regulation remain underexplored. The primary cause of these issues may stem from the intricate amalgamation of core structure, defects, and surface states, inherent to CDs, which poses challenges in establishing a consistent generalization. This review succinctly summarizes the recently progress of ROS‐modulated approaches using CDs in disease treatment. Specifically, it investigates established therapeutic strategies based on CDs‐regulated ROS, emphasizing the interplay between intrinsic structure and ROS generation or scavenging ability. The conclusion raises several unresolved key scientific issues and prominent technological bottlenecks, and explores future perspectives for the comprehensive development of CDs‐based ROS‐modulating therapy.

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Safety Landscape of Therapeutic Nanozymes and Future Research Directions

Tagaras,

Song,

Sahar

et al. 2024

Advanced Science

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Oxidative stress and inflammation are at the root of a multitude of diseases. Treatment of these conditions is often necessary but current standard therapies to fight excessive reactive oxygen species (ROS) and inflammation are often ineffective or complicated by substantial safety concerns. Nanozymes are emerging nanomaterials with intrinsic enzyme‐like properties that hold great promise for effective cancer treatment, bacterial elimination, and anti‐inflammatory/anti‐oxidant therapy. While there is rapid progress in tailoring their catalytic activities as evidenced by the recent integration of single‐atom catalysts (SACs) to create next‐generation nanozymes with superior activity, selectivity, and stability, a better understanding and tuning of their safety profile is imperative for successful clinical translation. This review outlines the current applied safety assessment approaches and provides a comprehensive summary of the safety knowledge of therapeutic nanozymes. Overall, nanozymes so far show good in vitro and in vivo biocompatibility despite considerable differences in their composition and enzymatic activities. However, current safety investigations mostly cover a limited set of basic toxicological endpoints, which do not allow for a thorough and deep assessment. Ultimately, remaining research gaps that should be carefully addressed in future studies are highlighted, to optimize the safety profile of therapeutic nanozymes early in their pre‐clinical development.

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Natural Metal Polyphenol Nanozyme: Free Radical Scavenging and Antioxidation for the Treatment of Acute Kidney Injury

Cited by 13 publications

References 39 publications

Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin

Lignin-Based Antioxidant Hydrogel Patch for the Management of Atopic Dermatitis by Mitigating Oxidative Stress in the Skin

Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Safety Landscape of Therapeutic Nanozymes and Future Research Directions

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