1991
DOI: 10.1016/s0099-2399(06)81830-3
|View full text |Cite
|
Sign up to set email alerts
|

Natural modifiers of the inflammatory process in the human dental pulp

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1

Citation Types

1
13
0
1

Year Published

1992
1992
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 14 publications
(15 citation statements)
references
References 13 publications
1
13
0
1
Order By: Relevance
“…Labeling for ot-2M occurred in moderate amounts within the extravascular compartment of inflamed pulpal tissue sections but in only mild amounts within the extravascular domain of healthy pulpal samples. The intensity of gold-labeling of this protein appeared to be directly related to the presence ofserum and/or inflammationwithin the tissue section, which is consistent with the findings of McClanahan et al (1991). This suggests a physiological release of a-2M in response to increased levels of PMN-E and PMN-CG or pulpal connective tissue destruction.…”
Section: Discussionsupporting
confidence: 83%
See 2 more Smart Citations
“…Labeling for ot-2M occurred in moderate amounts within the extravascular compartment of inflamed pulpal tissue sections but in only mild amounts within the extravascular domain of healthy pulpal samples. The intensity of gold-labeling of this protein appeared to be directly related to the presence ofserum and/or inflammationwithin the tissue section, which is consistent with the findings of McClanahan et al (1991). This suggests a physiological release of a-2M in response to increased levels of PMN-E and PMN-CG or pulpal connective tissue destruction.…”
Section: Discussionsupporting
confidence: 83%
“…Fortunately, the host normally offsets these destructive proteases with natural serum inhibitors such as ao-2M. ox-2M has been demonstrated to be present in significant concentrations during irreversible pulpal inflammation (McClanahan et al, 1991). Pulpal connective tissue destruction, associated with PMN degranulation, probably occurs when proteases such as PMN-E and PMN-CG are released to the extracellular collagen matrix and their concentrations exceed the inhibitory levels of a-2M in the area.…”
mentioning
confidence: 99%
See 1 more Smart Citation
“…A disturbance of the final packaging or of the salvage pathway of the lysosomal enzymes as well as increased phagocytosis, autolysis, or cellular death seem to be the most likely explanations of the increased enzyme leakage into the peritoneal fluid of patients with peritonitis. Increased activity of lysosomal enzymes in extracellular fluids has been found in experimentally induced inflammation 10 -14 and in inflammatory disorders, such as in the synovial fluid of rheumatoid arthritis, 15 pulpal inflammatory disease, 16 gingival crevicular fluid, 17 and CSF of bacterial meningitis 7 and in the plasma of patients with acquired immunodeficiency syndrome. 18 The absence of a correlation between enzyme activity and the number of leukocytes in the peritoneal fluid indicates that the enzyme leakage is not restricted to the freely floating leukocytes in the peritoneal fluid, but it results mainly from the inflamed tissues of the peritoneal cavity.…”
Section: Discussionmentioning
confidence: 99%
“…Frozen pulp samples were thawed for 15 min, and the tissue was crushed with a glass rod in an Eppendorf tube to elute the cytokines from the pulp tissue (7,8). Concentrations of IL-1α, IL-6, and IL-8 were measured using an Invitrogen Immunoassay Kit (#KAC1192/KAC1191, #KHC0061, and #KHC0081, Invitrogen Corporation, Grand Island, NY, USA), employing a double-antibody sandwich technique.…”
Section: Elisa Proceduresmentioning
confidence: 99%