Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach

Akram, Rabia; Anwar, Haseeb; Javed, Muhammad; Imran, Ali; Rasul, Azhar; Malik, Shoaib Ahmad; Manzoor, Mobina; Islam, Fakhar; Khan, Ikram Ullah; Sajid, Faiqa; Iman, Tehreem; Shah, Muhammad Ajmal; Sun, Tao; Hussain, Ghulam; Shah, Mohd Asif

doi:10.1080/10942912.2023.2189569

International Journal of Food Properties

2023

DOI: 10.1080/10942912.2023.2189569

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Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach

Rabia Akram

Haseeb Anwar

Muhammad Javed

et al.

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2024

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Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy: Emphasis on Neuro-inflammation and Allodynia

Changkakoti,

Das,

Borah

et al. 2024

EMIDDT

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Abstract:: According to the World Health Organization (WHO), diabetes has been increasing steadily over the past few decades. In developing countries, it is the cause of increased morbidity and mortality. Diabetes and its complications are associated with education, occupation, and income across all levels of socioeconomic status. Factors, such as hyperglycemia, social ignorance, lack of proper health knowledge, and late access to medical care, can worsen diabetic complications. Amongst the complications, neuropathic pain and inflammation are considered the most common causes of morbidity for common populations. This review is focused on exploring protein kinase C (PKC)-mediated TGF-β regulation in diabetic complications with particular emphasis on allodynia. The role of PKC-triggered TGF-β in diabetic neuropathy is not well explored. This review will provide a better understanding of the PKC-mediated TGF-β regulation in diabetic neuropathy with several schematic illustrations. Neuroinflammation and associated hyperalgesia and allodynia during microvascular complications in diabetes are scientifically illustrated in this review. It is hoped that this review will facilitate biomedical scientists to better understand the etiology and target drugs effectively to manage diabetes and diabetic neuropathy.

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Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy: Emphasis on Neuro-inflammation and Allodynia

Changkakoti,

Das,

Borah

et al. 2024

EMIDDT

View full text Add to dashboard Cite

show abstract

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Natural molecules as promising players against diabetic peripheral neuropathy: an emerging nutraceutical approach

Cited by 1 publication

References 131 publications

Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy: Emphasis on Neuro-inflammation and Allodynia

Protein Kinase C (PKC)-mediated TGF-β Regulation in Diabetic Neuropathy: Emphasis on Neuro-inflammation and Allodynia

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