Natural organic matter (NOM) induces oxidative stress in freshwater amphipods Gammarus lacustris Sars and Gammarus tigrinus (Sexton)

Timofeyev, Maxim A.; Shatilina, Z. M.; Колесниченко, А. В.; Bedulina, Daria; Колесниченко, В. В.; Pflugmacher, Stephan; Steinberg, Christian E. W.

doi:10.1016/j.scitotenv.2006.02.003

Cited by 70 publications

(27 citation statements)

References 42 publications

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“…In ecotoxicology, experiments with gammarids as biological models were frequently conducted on males only (Naylor et al 1989;Pantani et al 1997;Maltby et al 2002;Felten et al 2008;Xuereb et al 2009) or gender where not distinguished (Timofeyev et al 2006(Timofeyev et al , 2008Adam et al 2009;Alonso et al 2010). Our results reveal a gender-based sensitivity probably due to physiological properties corresponding with gender.…”

Section: Discussionmentioning

confidence: 70%

“…In three spiny sticklebacks exposed to copper, Sanchez et al (2005) observed a rapid and transient response of antioxidant enzymes. Timofeyev et al (2006) exposed Gammarus lacustris and G. tigrinus to natural organic matter and observed antioxidant enzyme variations for 0.5 h of exposure and responses were transient. Thus, variations in antioxidant enzymes cannot be predicted but differ according to exposure time, concentration level and biological organism.…”

Section: Oxidative Stressmentioning

confidence: 99%

“…Gammarids are used to measure metal accumulation and provide information about contamination levels of aquatic ecosystems (Zauke et al 1995;Barkács et al 2002;Rainbow 2002). In addition, several biomarkers have been measured in gammarids, such as metallothionein level (Geffard et al 2007), oxidative stress biomarkers (Correia et al 2004;Timofeyev et al 2006) and osmoregulatory parameters (Felten et al 2008). However, few experiments in ecotoxicology have involved Dikerogammarus villosus, even though this species is widely represented in Europe (Dick and Platvoet 2000;Bij de Vaate et al 2002;Grabowski et al 2007;Gherardi et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Effects of sublethal copper exposure on two gammarid species: which is the best competitor?

Sroda¹,

Cossu-Leguille²

2010

Ecotoxicology

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Biomarker responses in organisms exposed to copper were examined by comparing two gammarid species, Gammarus roeseli and Dikerogammarus villosus, based on gender. G. roeseli specimens were exposed to 20 μg/L of copper for 6, 12, 24 and 48-h periods, while D. villosus were exposed to 20 and 30 μg/L of copper for 12, 48 and 72 h. Males and females of each species were exposed separately and biomarker measurements were performed for each species and gender. The selected biomarkers were antioxidant enzymes as total glutathione peroxidase (GPxtot), selenium-dependent glutathione peroxidase (SeGPx), and catalase activities. Malondialdehyde level (MDA) was measured as a biomarker of toxic effect. Energy reserves were evaluated by means of lipid, glycogen and protein levels. For both species and gender, antioxidant enzyme activities were weakly modified by copper exposure and differences were transient. MDA levels were increased in both species and genders in exposed animals compared to controls, when energy reserves were decreased. G. roeseli was more rapidly overwhelmed by copper toxicity while the first response of D. villosus was the mobilization of its energetic content. D. Villosus probably has specific physiological properties that enable it to cope with copper toxicity and thus become the best competitor.

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Section: Discussionmentioning

confidence: 70%

Section: Oxidative Stressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Effects of sublethal copper exposure on two gammarid species: which is the best competitor?

Sroda¹,

Cossu-Leguille²

2010

Ecotoxicology

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“…ROS are highly reactive and can react with many intracellular molecules. The main cellular components susceptible to ROS are lipids with subsequent peroxidation of unsaturated fatty acids in membranes, proteins with subsequent denaturation, as well as carbohydrates and nucleic acids (Blokhina et al, 2003;Timofeyev et al, 2006). Therefore, endomembrane systems of spermatogonia and Sertoli cells in our ultrastructural observation are easily damaged by oxidative stress caused by MCs.…”

Section: Discussion Damaged Ultrastructure and Oxidative Stress In Tementioning

confidence: 87%

Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis

Liu¹,

Xie²,

Qiu³

et al. 2009

Environmental Toxicology

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In the present research, the changes of ultrastructures and biochemical index in rabbit testis were examined after i.p. injection with 12.5 lg/kg microcystin (MC) extracts. Ultrastructural observation showed widened intercellular junction, distention of mitochondria, endoplasmic reticulum, and Golgi apparatus. All these changes appeared at 1, 3, and 12 h, but recovered finally. In biochemical analyses, the levels of lipid peroxidation (MDA) and H 2 O 2 increased significantly at 1 h, indicating MC-caused oxidative stress. Finally, H 2 O 2 decreased to the normal levels, while MDA remained at high levels. The antioxidative enzymes (CAT, SOD, GPx, GST) and antioxidants (GSH) also increased rapidly at 1 h, demonstrating a quick response of the defense systems to the oxidative stress. Finally, the activity of CAT, SOD, and GPX recovered to the normal level, while the activity of GST and the concentration of GSH remained at a high level. This suggests that the importance of MCs detoxification by GST via GSH, and the testis of rabbit contained abundant GSH. The final recovery of ultrastructure and some biochemical indexes indicates that the defense systems finally succeeded in protecting the testis against oxidative damage. In conclusion, these results indicate that the MCs are toxic to the male rabbit reproductive system and the mechanism underlying this toxicity might to be the oxidative stress caused by MCs. Although the negative effects of MCs can be overcome by the antioxidant system of testis in this study, the potential reproductive risks of MCs should not be neglected because of their wide occurrence. #

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“…Malondialdehyde, a breakdown product of lipid endoperoxides, is an expression of lipid peroxidation, and has been used with success in aquatic invertebrates as a general indicator of toxicant stress derived from various types of contamination (Zwart et al, '99;Livingstone, 2001;Wilhelm et al, 2001;Timofeyev et al, 2006). Neuparth et al (2005) reported that Gammarus locusta maintained on highly organic sediments showed higher levels of lipoperoxidation.…”

mentioning

confidence: 99%

Biochemical composition, lipoperoxidation, Na⁺/K⁺ATPase activity and reproduction of Hyalella castroi (amphipoda, dogielinotidae) fed with different diets

et al. 2009

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This study compared the effect of different diets on the biochemical composition (lipids, cholesterol, proteins and glycogen) and the levels of lipoperoxidation and activity of Na(+)/K(+)ATPase of Hyalella castroi. We also investigated some patterns of the life cycle including survival, precopulatory mating pairs and number of ovigerous females after 21 days of culture with different diets. These crustaceans live in limnetic environments of the plateau (1,200 m a.s.l.) of the state of Rio Grande do Sul, in southern Brazil. Adult animals were collected in the autumn of 2006 in São José dos Ausentes. In the laboratory, the animals were kept submerged in aquariums, separated by sex, under controlled conditions. They were fed ad libitum for 21 days with different diets, and then some were used for biochemical determinations and others for observations of reproductive aspects. Statistical analysis revealed significant differences in the responses to glycogen, total proteins, lipoperoxidation levels and Na(+)/K(+)ATPase activity in both sexes of these amphipods and total lipids and total cholesterol levels only in females. These diets changed the biochemical patterns of the animals taken from the natural environment, and allowed a high survival rate but did not improve reproduction.

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Natural organic matter (NOM) induces oxidative stress in freshwater amphipods Gammarus lacustris Sars and Gammarus tigrinus (Sexton)

Cited by 70 publications

References 42 publications

Effects of sublethal copper exposure on two gammarid species: which is the best competitor?

Effects of sublethal copper exposure on two gammarid species: which is the best competitor?

Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis

Biochemical composition, lipoperoxidation, Na⁺/K⁺ATPase activity and reproduction of Hyalella castroi (amphipoda, dogielinotidae) fed with different diets

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Natural organic matter (NOM) induces oxidative stress in freshwater amphipods Gammarus lacustris Sars and Gammarus tigrinus (Sexton)

Cited by 70 publications

References 42 publications

Effects of sublethal copper exposure on two gammarid species: which is the best competitor?

Effects of sublethal copper exposure on two gammarid species: which is the best competitor?

Microcystin extracts induce ultrastructural damage and biochemical disturbance in male rabbit testis

Biochemical composition, lipoperoxidation, Na+/K+ATPase activity and reproduction of Hyalella castroi (amphipoda, dogielinotidae) fed with different diets

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Biochemical composition, lipoperoxidation, Na⁺/K⁺ATPase activity and reproduction of Hyalella castroi (amphipoda, dogielinotidae) fed with different diets