Natural polyamines-linked cyclophosphazenes. Attempts at the production of more selective antitumorals

Chiral configurations in cyclophosphazene chemistry

“…Structural and mechanistic studies were mainly concerned with positional isomers and the geminal or nongeminal replacement paths [12][13][14][15][16]. Many geometrical isomers have also been characterized, particularly for cis and trans 1,3-disubstituted cyclotriphosphazene derivatives.…”

“…Cyclophosphazenes and their derivatives have been of considerable interest for a number of years, partly because of their versatile chemistry [12][13][14][15][16] and partly because it is possible to use them to design materials with special properties such as thermal stability, catalytic properties, electrical conductivity, liquid crystals and biomedical activity [17][18][19][20]. A large part of the literature of cyclophosphazene chemistry deals with symmetrically-substituted moieties, (NPX 2 ), in which the tetra-coordinated pentavalent phosphorus atoms is not a center of chirality and it was only when unsymmetrically-substituted phosphazene units, (NPXY), were considered that the possibility of optical isomerism in cyclophosphazene derivatives was realized in 1962 [12].…”

On the Preparation and Characterization of Polyethylene/Polyamide Blends by Melt Processing in the Presence of an Ethylene/Acrylic Acid Copolymer and of New Phosphazene Compounds

“…[14,15] Cyclo(organo)phosphazenes (CP) are low-molecularweight phosphazene derivatives, whose cyclic structure is formed by repeating -P--N units, each phosphorus bearing two substituent groups (usually, but not necessarily, organic in nature). CPs find applications in several fields such as biomaterials, [16,17] photochemistry, [18][19][20][21][22][23] sol-gel precursors, [24,25] core for dendrimers or star polymers, [26][27][28][29][30] preparation of linear organic macromolecules with CP moieties, [31] fire retardant additives. [32] CPs substituted with azide or 2-oxazoline groups have been used in the selective reticulation of polyolefins and in the chain extension of poly(ethylene terephthalate) (PET) and PA6.…”

Structure of the first genuine ansa derivative, N3P3Cl4[HN(CH2)2O(CH2)2NH]

“…The ansa structure was identified both by NMR and X-ray studies (Labarre, 1985;Galy, Enjalbert & Labarre, unpublished results). It must be emphasized that this mono ansa derivative was obtained first by the skilful use of the electron-donor properties of the methyl group for the linkage of the amino group of the 3-amino-1-propanol and then of its OH group (under drastic conditions) to the adjacent P atom of the cyclophosphazenic ring.…”

“…The so-called spiro loop versus ansa arch controversy related to the structure of products of the reaction of hexachlorocyclotriphosphazene, N3PaC16, with difunctional reagents has been clarified recently. In fact, no genuine ansa derivative from N3PaC16 itself has ever been observed, whereas many compounds containing one or several difunctional groups grafted in spiro (loop) and/or bino (bridge) configurations are now well documented, their neat synthesis coming under the rules of the BASIC chemical game, a kind of 'Lego box of bricks' on the ~ngstr6m scale (Labarre, 1985). Until recently, the only mono ansa species within the cyclophosphazenic series was obtained (Harris & Williams, 1984) by reaction of 3-amino-l-propanol with the monomethyl derivative of N3PaC16, i.e.…”