Natural Polymeric Nanobiocomposites for Anti-Cancer Drug Delivery Therapeutics: A Recent Update

Abstract

Cancer is one of the most common lethal diseases and the leading cause of mortality worldwide. Effective cancer treatment is a global problem, and subsequent advancements in nanomedicine are useful as substitute management for anti-cancer agents. Nanotechnology, which is gaining popularity, enables fast-expanding delivery methods in science for curing diseases in a site-specific approach, utilizing natural bioactive substances because several studies have established that natural plant-based bioactive compounds can improve the effectiveness of chemotherapy. Bioactive, in combination with nanotechnology, is an exceptionally alluring and recent development in the fight against cancer. Along with their nutritional advantages, natural bioactive chemicals may be used as chemotherapeutic medications to manage cancer. Alginate, starch, xanthan gum, pectin, guar gum, hyaluronic acid, gelatin, albumin, collagen, cellulose, chitosan, and other biopolymers have been employed successfully in the delivery of medicinal products to particular sites. Due to their biodegradability, natural polymeric nanobiocomposites have garnered much interest in developing novel anti-cancer drug delivery methods. There are several techniques to create biopolymer-based nanoparticle systems. However, these systems must be created in an affordable and environmentally sustainable way to be more readily available, selective, and less hazardous to increase treatment effectiveness. Thus, an extensive comprehension of the various facets and recent developments in natural polymeric nanobiocomposites utilized to deliver anti-cancer drugs is imperative. The present article provides an overview of the latest research and developments in natural polymeric nanobiocomposites, particularly emphasizing their applications in the controlled and targeted delivery of anti-cancer drugs.

Recent Advances in Nanotechnology-Based Drug Delivery Systems for the Diagnosis and Treatment of Reproductive Disorders

“…The pronounced biocompatibility and low toxicity inherent in nanoparticles sourced from nature are underpinned by scientific evidence demonstrating their compatibility with biological systems. 96 Studies have highlighted their reduced risk of adverse reactions, ensuring a safer interaction with biological tissues. Furthermore, the controlled release properties exhibited by these natural-source nanoparticles have been substantiated in controlled experiments, demonstrating their ability to modulate drug delivery kinetics.…”

“…The integration of natural sources into nanoparticle formulation seamlessly aligns with the escalating emphasis on eco-friendly and biodegradable approaches in the medical domain. The pronounced biocompatibility and low toxicity inherent in nanoparticles sourced from nature are underpinned by scientific evidence demonstrating their compatibility with biological systems . Studies have highlighted their reduced risk of adverse reactions, ensuring a safer interaction with biological tissues.…”

Recent Advances in Micro- and Nano-Drug Delivery Systems Based on Natural and Synthetic Biomaterials

“…The surface modification of drug carriers with bioactive compounds can be done in a number of different ways. It is possible to apply modified coatings (for instance, ones that include albumin and chitosan) in order to limit the enzymatic breakdown that occurs in the gastrointestinal tract and plasma [164].…”

Enhancing Osteoporosis Treatment through Targeted Nanoparticle Delivery of Risedronate: In Vivo Evaluation and Bioavailability Enhancement

“…Chitosan, a polymer of significant interest in biomedical and pharmaceutical sciences, is renowned for its remarkable versatility, but has pH-dependent solubility [ 8 ]. Several derivatives were synthesized to address the solubility limitation and enhance chitosan’s mucoadhesive features.…”