1998
DOI: 10.4269/ajtmh.1998.58.81
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Natural polymorphism in the thrombospondin-related adhesive protein of Plasmodium falciparum.

Abstract: Abstract. We have developed a typing system using natural sequence variation in the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium falciparum. This method permits a haplotype to be assigned to any particular TRAP gene. We have applied this method to a hospital-based, case control-study in Mali. Previous sequence variation and conservation in TRAP has been confirmed. Particular TRAP haplotypes can be used as geographic hallmarks. Because of the high level of conflict between characters, we ha… Show more

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Cited by 28 publications
(31 citation statements)
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“…From a population in Mali, a sample of 242 haplotypes of the trap (thrombospondin-related adhesive protein) gene (located on chromosome 13; ref. 1) was typed at several sequence sites, of which five were highly informative (with common allele frequencies of Ͻ0.9; four restriction fragment length polymorphism sites and one polymorphic repeat) covering approximately 1.0 kb (33). With these data (full tabulation of haplotypes kindly provided by K. J. H. Robson, Univ.…”
Section: Discussionmentioning
confidence: 99%
“…From a population in Mali, a sample of 242 haplotypes of the trap (thrombospondin-related adhesive protein) gene (located on chromosome 13; ref. 1) was typed at several sequence sites, of which five were highly informative (with common allele frequencies of Ͻ0.9; four restriction fragment length polymorphism sites and one polymorphic repeat) covering approximately 1.0 kb (33). With these data (full tabulation of haplotypes kindly provided by K. J. H. Robson, Univ.…”
Section: Discussionmentioning
confidence: 99%
“…TRAPs are characterized by the presence of two adhesive modules: one or more von Willebrand factor A (vWA)-like domains, and one or more thrombospondin type 1 (TSP1)-like modules. TSP1-like domains were first identified as "region II" within the Plasmodium circumsporozoite protein (12) which, after the isolation of Plasmodium TRAP (36), was identified as a domain also present in thrombospondin and properdin. A series of studies describe a critical role for TSP1-containing proteins as mediators of host-parasite interactions and in the gliding motility of the parasite (28,29,47,51).…”
mentioning
confidence: 99%
“…As for the TRAPs of Plasmodium sp. (36,37), polymorphism has been observed in TRAPC1 and TRAPC2, and PCR-based polymorphism analyses of TRAPC1 and TRAPC2 have been used for genetic fingerprinting of C. parvum isolates of human and bovine origin (26,33,34,48).…”
mentioning
confidence: 99%
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“…Anti-repeat monoclonal antibodies have been shown to at least partially inhibit sporozoite invasion in vitro [61] and potent T-cell responses have been identified in individuals vaccinated with irradiated sporozoites [62,63] as well as people www.intechopen.com who are naturally exposed to malaria [64]. TRAP is highly polymorphic [65] and has also been shown to be under strong diversifying selection suggesting that it is a natural immune target [66].…”
Section: Thrombospondin Related Adhesion Protein (Trap)mentioning
confidence: 99%