Natural polyphenolic nanodot-knotted conductive hydrogels for flexible wearable sensors

Yang, Peng; Zhang, Jianhua; Zhang, Rong; Duan, Gaigai; Li, Yiwen; Li, Zhan

doi:10.1039/d3gc04952c

Cited by 14 publications

(1 citation statement)

References 43 publications

(53 reference statements)

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“…In recent years, there has been significant interest in conductive hydrogels for wearable electronic devices, comprising chemically or physically cross-linked polymer networks, uniformly dispersed conductive fillers, and high water content. − While many of these hydrogels demonstrate favorable mechanical properties and impressive stretchability, they often fall short in terms of conductivity or sensitivity. Conversely, those with exceptional conductivity and sensitivity tend to sacrifice flexibility and lack self-healing capabilities.…”

Section: Introductionmentioning

confidence: 99%

Enhancing Mechanical and Sensing Performance of Conductive Hydrogel via Ga-Droplet Costabilization with Polyaniline and Xanthan Gum

Lu,

Liu,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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Conductive hydrogels incorporating liquid metals, particularly gallium (Ga) droplets, have garnered significant attention owing to the multifaceted functionalities they offer. In this study, we introduce a liquid-metal-based conductive hydrogel synthesized through radical polymerization of acrylic acid (AA) in the presence of Ga droplets stabilized by polyaniline (PANI) nanofibers and xanthan gum (XG) at room temperature. The incorporation of PANI not only enhances the stability of Ga-droplet dispersion but also improves the hydrogel’s mechanical properties, including tensile strength, toughness, and sensitivity as a sensor material. With the addition of 0.5 wt % PANI, the hydrogel displays an elongation at break of 964% and a tensile strength of 265 kPa, while exhibiting a sensor gauge factor (GF) of 13.4 within a strain range of 400–600%. The reversible noncovalent cross-links within the hydrogel confer excellent self-healing properties, achieving 98% self-healing efficiency in elongation at break within 6 h and 90% conductivity self-healing within 83 ms. Additionally, the hydrogel’s abundant functional groups enable strong adhesion to various substrates. As a sensing material, the hydrogel demonstrates rapid response and recovery times (250/250 ms), low detection limits (0.1%), and good durability (500 cycles under 10 and 100% strains). The cross-linked network composed of XG, PANI, and PAA imparts the hydrogel with water retention. Moreover, glycerol treatment reinforces the hydrogel’s mechanical strength and sensing abilities, extending their effectiveness even under extreme temperature conditions. As a result, the XG-PANI-Ga-PAA hydrogel-based strain sensor has emerged as a promising tool for monitoring human health and detecting a wide range of human activities with reliability and precision.

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Section: Introductionmentioning

confidence: 99%

Enhancing Mechanical and Sensing Performance of Conductive Hydrogel via Ga-Droplet Costabilization with Polyaniline and Xanthan Gum

Lu,

Liu,

Liu

et al. 2024

ACS Appl. Polym. Mater.

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Fabricating Water‐Resistant and Stimuli Responsive Smart Hydrogels via Iminoboronate Chemistry

Hu,

Li,

et al. 2024

Adv Funct Materials

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The construction and application of smart hydrogels often involve balancing the conflicting relationship between the stability and dynamics. Imine bond, as a type of dynamic chemical bonding, is commonly used in the construction of diverse smart hydrogels since it can effectively achieve the response to some external stimuli. However, its poor thermodynamic stability often leads to the limited crosslinking density and easy degradation of hydrogels in water and biofluids. To address this critical issue, a series of model smart hydrogels is prepared with highly water stability and stimuli responsiveness via the iminoboronate gelation of aminoglycosides and 8‐arm PEG terminated with 2‐acetylphenylboronic acid pinacol ester [(pin)‐APBA]. Note that the presence of pinacol esters, as electron‐donating agents and hydrophobic couplers with large steric hindrance, can keep the five‐membered ring of iminoboronate intact and protect the nitrogen‐boron (N─B) coordination bond from water molecules, offering the water resistance feature of the hydrogels. And the rapid responsiveness of the gels to stimuli (e.g., acid, H2O2 and unhindered amines) further confirmed that their dynamic nature, allowing the on‐demand release of aminoglycosides with satisfactory antibacterial effect. This iminoboronate chemistry‐based strategy can offer new opportunities toward stable and smart hydrogels with various applications in many fields.

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Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy

Yuan,

Liu,

Wang

et al. 2024

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The strong anti‐inflammatory effect of methylprednisolone (MP) is a necessary treatment for various severe cases including acute spinal cord injury (SCI). However, concerns have been raised regarding adverse effects from MP, which also severely limits its clinical application. Natural polyphenols, due to their rich phenolic hydroxyl chemical properties, can form dynamic structures without additional modification, achieving targeted enrichment and drug release at the disease lesion, making them a highly promising carrier. Considering the clinical application challenges of MP, a natural polyphenolic platform is employed for targeted and efficient delivery of MP, reducing its systemic side effects. Both in vitro and SCI models demonstrated polyphenols have multiple advantages as carriers for delivering MP: (1) Achieved maximum enrichment at the injured site in 2 h post‐administration, which met the desires of early treatment for diseases; (2) Traceless release of MP; (3) Reducing its side effects; (4) Endowed treatment system with new antioxidative properties, which is also an aspect that needs to be addressed for diseases treatment. This study highlighted a promising prospect of the robust delivery system based on natural polyphenols can successfully overcome the barrier of MP treatment, providing the possibility for its widespread clinical application.

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Natural polyphenolic nanodot-knotted conductive hydrogels for flexible wearable sensors

Abstract: Conductive hydrogels have emerged as excellent candidate materials for designing and fabricating flexible wearable sensors. However, there are still critical challenges in preparing high-performance, strongly adhesive, and biocompatible hydrogels through...

Cited by 14 publications

References 43 publications

Enhancing Mechanical and Sensing Performance of Conductive Hydrogel via Ga-Droplet Costabilization with Polyaniline and Xanthan Gum

Enhancing Mechanical and Sensing Performance of Conductive Hydrogel via Ga-Droplet Costabilization with Polyaniline and Xanthan Gum

Fabricating Water‐Resistant and Stimuli Responsive Smart Hydrogels via Iminoboronate Chemistry

Natural Polyphenol Delivered Methylprednisolone Achieve Targeted Enrichment for Acute Spinal Cord Injury Therapy

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