Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism

Priego, Sonia; Feddi, Fatima; Ferrer, Paula; Mena, Salvador; Benlloch, María; Ortega, Ángel; Carretero, Julián; Obrador, Elena; Asensi, Miguel; Estrela, José M.

doi:10.1158/1535-7163.mct-08-0363

Cited by 88 publications

(63 citation statements)

References 61 publications

(58 reference statements)

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“…S6A and S6B). To further verify the role of NF-kB signaling in GICs, we used two NF-kB inhibitors, caffeic acid phenethyl ester (CAPE) and pterostilbene (29,30). These inhibitors dramatically blocked the proliferation of both hGIC and NSCL61 in a dosedependent manner (Fig.…”

Section: Eva1 Increased the Expression Of Stemness-related Genes And mentioning

confidence: 99%

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway

Ohtsu

Nakatani²,

Yamashita

et al. 2016

Cancer Research

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Glioblastoma (GBM)-initiating cells (GIC) are a tumorigenic subpopulation that are resistant to radio-and chemotherapies and are the source of disease recurrence. Therefore, the identification and characterization of GIC-specific factors is critical toward the generation of effective GBM therapeutics. In this study, we investigated the role of epithelial V-like antigen 1 (Eva1, also known as myelin protein zero-like 2) in stemness and GBM tumorigenesis. Eva1 was prominently expressed in GICs in vitro and in stem cell marker (Sox2, CD15, CD49f)-expressing cells derived from human GBM tissues. Eva1 knockdown in GICs reduced their self-renewal and tumor-forming capabilities, whereas Eva1 overexpression enhanced these properties. Eva1 deficiency was also associated with decreased expression of stemnessrelated genes, indicating a requirement for Eva1 in maintaining GIC pluripotency. We further demonstrate that Eva1 induced GIC proliferation through the activation of the RelB-dependent noncanonical NF-kB pathway by recruiting TRAF2 to the cytoplasmic tail. Taken together, our findings highlight Eva1 as a novel regulator of GIC function and also provide new mechanistic insight into the role of noncanonical NF-kB activation in GIC, thus offering multiple potential therapeutic targets for preclinical investigation in GBM.

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Section: Eva1 Increased the Expression Of Stemness-related Genes And mentioning

confidence: 99%

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway

Ohtsu

Nakatani²,

Yamashita

et al. 2016

Cancer Research

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“…Carnosol (43) and carnosic acid (44) are two polyphenols of this group that are of relevance to kinase targeting and they were isolated from culinary herbs that include rosemary, sage and oregano (Table 4) [87].…”

Section: Polyphenolic Diterpenesmentioning

confidence: 99%

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Lamoral-Theys¹,

Pottier

Dufrasne³

et al. 2010

CMC

124

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Over eleven hundred publications reporting anticancer activities of polyphenols have appeared in the peerreviewed literature. In addition, a search of the PubMed database using "polyphenols -cancer -review" as keywords produced over 320 hits for review articles (July 2009). Polyphenol anticancer activities include, among others, anti-oxidative, pro-apoptotic, DNA damaging, anti-angiogenic, and immunostimulatory effects. Targeting specific protein kinases to combat cancer represents a major focus of oncology research within the so-called targeted therapy approach. An exhaustive search of the PubMed database (July 2009) using "polyphenols -cancer -kinases" as keywords resulted in more than 130 hits, half of them having been published within the past five years. Furthermore, the PubMed database contains 25 reviews on the subject of anti-kinase activity of some specific polyphenols, including mainly curcumin and the green tea polyphenol (-)-epigallocatechin 3-gallate (EGCG). However, no attempt has been made yet to review this area of research in a comprehensive, general manner. The current review therefore aims to highlight those anticancer polyphenols that target specific kinases in various types of cancer. The present review also provides an in-depth analysis of polyphenol structure-activity relationships in relation to their anticancer activities and specific kinase targeting. Lastly, a number of polyphenols are identified as potential antitumor agents that could be used to combat biologically aggressive cancers, including metastasizing cancers, through the targeting of specific kinases.

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“…Several in vitro studies have shown consistent anticancer effects of quercetin in a variety of cancer cell lines and tumors, including U138MG (glioma) [12], HeLa (cervical cancer) [13], MDA-MB-453 (breast cancer) [14], HT-29 (colorectal xenografts) [15], myeloid leukemia [16] and oral cavity cancer [17].…”

Section: Introductionmentioning

confidence: 99%

Mesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies

Sapino

Ugazio

Gastaldi

et al. 2015

European Journal of Pharmaceutics and Biopharmaceutics

140

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The flavonoid quercetin is extensively studied for its antioxidant and chemopreventive properties.However the poor water-solubility, low stability and short half-life could restrict its use in skin care products and therapy.The present study is aimed to evaluate the potential of aminopropyl functionalized mesoporous silica nanoparticles (NH 2 -MSN) as topical carrier system for quercetin delivery. Thermo gravimetric analysis, X-ray diffraction, high resolution transmission electron microscopy, nitrogen adsorption isotherms, FT-IR spectroscopy, zeta potential measurements and differential scanning calorimetry allowed analyzing with great detail the organic-inorganic molecular interaction.The protective effect of this vehicle on UV-induced degradation of the flavonoid was investigated revealing a certain positive influence of the inclusion on the photostability over time.Epidermal accumulation and transdermal permeation of this molecule were ex vivo evaluated using porcine skin mounted on Franz diffusion cells. The inclusion complexation with the inorganic nanoparticles increased the penetration of quercetin into the skin after 24 h post-application without transdermal delivery.The effect of quercetin alone or given as complex with NH 2 -MSN on proliferation of JR8 human melanoma cells was evaluated by sulforhodamine B colorimetric proliferation assay. At a concentration 60 M the complex with NH 2 -MSN was more effective than quercetin alone, causing about 50% inhibition of cell proliferation.

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Natural polyphenols facilitate elimination of HT-29 colorectal cancer xenografts by chemoradiotherapy: a Bcl-2- and superoxide dismutase 2-dependent mechanism

Cited by 88 publications

References 61 publications

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway

Eva1 Maintains the Stem-like Character of Glioblastoma-Initiating Cells by Activating the Noncanonical NF-κB Signaling Pathway

Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

Mesoporous silica as topical nanocarriers for quercetin: characterization and in vitro studies

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