Natural polysaccharides promote chondrocyte adhesion and proliferation on magnetic nanoparticle/PVA composite hydrogels

Hou, Ruixia; Nie, Lei; Du, Gaolai; Xiong, Xiaopeng; Fu, Jun

doi:10.1016/j.colsurfb.2015.05.008

Cited by 53 publications

(32 citation statements)

References 45 publications

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“…Also, as-prepared hydrogel scaffolds showed good apatite forming ability [252]. Further, combination of HA and CTS showed promotion to cell adhesion and proliferation as compared to any single polysaccharide [254]. Summary of composition, mechanical properties, used cells, and targeted applications in most recent research activities in PVA-based hydrogels as described in the following sections are given in Table 1.…”

Section: Other Combinationsmentioning

confidence: 97%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

385

161

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Poly (vinyl alcohol) (PVA) is a hydrophilic polymer with excellent biocompatibility and has been applied in various biomedical areas due to its favorable properties. PVA-based hydrogels have been recognized as promising biomaterials and suitable candidate for tissue engineering applications and can be manipulated to act various critical roles.However, due to some disadvantages (i.e., lack of cell-adhesive property), it needs further modification for desired and targeted applications. This review highlights recent progress in the design and fabrication of PVA-based hydrogels, including cross-linking and processing techniques. Finally, major challenges and future perspectives in tissue engineering are briefly discussed. GRAPHICAL ABSTRACTDownloaded by [University of Sussex Library] at 08:36 28 June 2016 2

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Section: Other Combinationsmentioning

confidence: 97%

PVA-based hydrogels for tissue engineering: A review

Kumar

Han

2016

International Journal of Polymeric Materials and Polymeric Biom

385

161

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“…In addition, the freeze‐thawing approach was used to produce Fe 2 O 3 /poly(vinyl alcohol) hydrogels . The freeze‐thawing approach to prepare physically crosslinked hydrogels is quite facile because it does not need any crosslinking reagent.…”

Section: Different Strategies For Developing Magnetic Hydrogelsmentioning

confidence: 99%

Recent advances in magnetic hydrogels

Zhang

Huang

2016

Polymer International

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Smart hydrogels that respond to magnetic field have attracted increasing interest in recent years. This is as a result of their numerous potential applications such as tunable delivery vehicles, magnetic resonance imaging (MRI) contrast agents and magnetic-heat therapy, etc. In this review, we summarize the methods for preparing magnetic hydrogels. Then we give an overview of magnetic hydrogels with various applications. Finally, the current limitations in the preparation and application of magnetic hydrogels will be discussed and the perspectives will be proposed for next generation of hydrogels.

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“…Polyvinyl alcohol (PVA) hydrogels possess excellent biocompatibility, high strength, water retention, and a porous structure [10][11][12]. However, the lack of biological activity does not support cell adhesion [13].…”

Section: Introductionmentioning

confidence: 99%

Structure and properties of PVA/silk fibroin hydrogels and their effects on growth behavior of various cell types

Hou

Wang

Han

et al. 2020

Mater. Res. Express

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Controllable regulation of cell behavior is one of the most important factors conducive to the restoration of tissue functions. Recently, various strategies have been developed using physical or chemical cues. Although these techniques are effective, the high cost and complex fabrication procedures impede their application. In this study, we used a low cost and simple strategy to fabricate PVA/silk fibroin composite hydrogels using a cyclic freeze-thaw method. With the increase of freezethaw cycles, the pore size of hydrogels decreased, the elastic modulus increased, and the swelling rate decreased. Furthermore, we chose two shapes of model cells, a spindle using bone marrow mesenchymal stem cells and smooth muscle cells, and a round shape using BV2 microglial cells. PVA/ silk fibroin composite hydrogels inhibited the adhesion and proliferation of stem cells and muscle cells and changed their cell shape from spindle to round, maintained the initial round shape of BV2 microglial cells, and promoted the proliferation of BV2 microglial cells. These results demonstrate that PVA/silk fibroin composite hydrogels can be used as a novel hydrogel system to regulate cell behavior.

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Natural polysaccharides promote chondrocyte adhesion and proliferation on magnetic nanoparticle/PVA composite hydrogels

Cited by 53 publications

References 45 publications

PVA-based hydrogels for tissue engineering: A review

PVA-based hydrogels for tissue engineering: A review

Recent advances in magnetic hydrogels

Structure and properties of PVA/silk fibroin hydrogels and their effects on growth behavior of various cell types

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