Natural-Product-Based Solutions for Tropical Infectious Diseases

Adegboye, Oyelola A.; Field, Matthew A.; Kupz, Andreas; Pai, Saparna; Sharma, Dileep; Smout, Michael J.; Wangchuk, Phurpa; Wong, Yide; Loiseau, Claire

doi:10.1128/cmr.00348-20

Cited by 23 publications

(13 citation statements)

References 334 publications

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“…Plants growing in the tropics produce more phenolics, flavonoids, and terpenoids during adaptation to its extreme vegetative and climatic conditions [14]. Phenolics and flavonoids are antioxidative and anti-inflammatory [15][16][17], and thus tropical plants may yield novel drug leads for treating infectious and non-infectious diseases, including chronic inflammatory conditions [18]. More than 900 medicinal plant species have been recorded in the Tropical region of Australia (shaded green in Figure 1) [19].…”

Section: Introductionmentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

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Australian tropical plants have been a rich source of food (bush food) and medicine to the first Australians (Aboriginal people), who are believed to have lived for more than 50,000 years. Plants such as spreading sneezeweed (Centipeda minima), goat’s foot (Ipomoea pes-caprae), and hop bush (Dodonaea viscosa and D. polyandra) are a few popular Aboriginal medicinal plants. Thus far, more than 900 medicinal plants have been recorded in the tropical region alone, and many of them are associated with diverse ethnomedicinal uses that belong to the traditional owners of Aboriginal people. In our effort to find anti-inflammatory lead compounds in collaboration with Aboriginal communities from their medicinal plants, we reviewed 78 medicinal plants used against various inflammation and inflammatory-related conditions by Aboriginal people. Out of those 78 species, we have included only 45 species whose crude extracts or isolated pure compounds showed anti-inflammatory properties. Upon investigating compounds isolated from 40 species (for five species, only crude extracts were studied), 83 compounds were associated with various anti-inflammatory properties. Alphitolic acid, Betulinic acid, Malabaric acid, and Hispidulin reduced proinflammatory cytokines and cyclooxygenase enzymes (COX-1 and 2) with IC50 values ranging from 11.5 to 46.9 uM. Other promising anti-inflammatory compounds are Brevilin A (from Centipeda minima), Eupalestin, and 5′-methoxy nobiletin (from Ageratum conyzoides), Calophyllolide (from Calophyllum inophyllum), and Brusatol (from Brucea javanica). D. polyandra is one example of an Aboriginal medicinal plant from which a novel anti-inflammatory benzoyl ester clerodane diterpenoid compound was obtained (compound name not disclosed), and it is in the development of topical medicines for inflammatory skin diseases. Medicinal plants in the tropics and those associated with indigenous knowledge of Aboriginal people could be a potential alternative source of novel anti-inflammatory therapeutics.

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Section: Introductionmentioning

confidence: 99%

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Yeshi

Turpin

Jamtsho³

et al. 2022

Molecules

Self Cite

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“…Thus, the development of innovative therapeutic strategies is imperative. At present, natural compounds or natural bioactive products have attracted much attention in treating infectious diseases due to their broad-spectrum antimicrobial activity and infrequent inducible drug resistance ( 10 , 11 ).…”

Section: Introductionmentioning

confidence: 99%

Antifungal Activity and Potential Action Mechanism of Allicin against Trichosporon asahii

Yang

Bai

et al. 2023

Microbiol Spectr

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“…The large population of microbes plays a critical and indispensable role in the life process, healthy balance, and disease development of their host species (Zhang et al, 2015 ; Cani, 2018 ; Gomes et al, 2018 ). Natural products from various sources had been explored as potential drug candidates in recent decades (Adegboye et al, 2021 ; Klunemann et al, 2021 ). With respect to the selection of natural products, scientists mainly performed their analysis depending on three traditional strategies that contain culture-based, (meta) genomics-based, and metabolomics-based approaches (Wang et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes

et al. 2022

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The beneficial metabolites of the microbiome could be used as a tool for screening drugs that have the potential for the therapy of various human diseases. Narrowing down the range of beneficial metabolite candidates in specific diseases was primarily a key step for further validation in model organisms. Herein, we proposed a reasonable hypothesis that the metabolites existing commonly in multiple beneficial (or negatively associated) bacteria might have a high probability of being effective drug candidates for specific diseases. According to this hypothesis, we screened metabolites associated with seven human diseases. For type I diabetes, 45 out of 88 screened metabolites had been reported as potential drugs in the literature. Meanwhile, 18 of these metabolites were specific to type I diabetes. Additionally, metabolite correlation could reflect disease relationships in some sense. Our results have demonstrated the potential of bioinformatics mining gut microbes' metabolites as drug candidates based on reported numerous microbe-disease associations and the Virtual Metabolic Human database. More subtle methods would be developed to ensure more accurate predictions.

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Natural-Product-Based Solutions for Tropical Infectious Diseases

Cited by 23 publications

References 334 publications

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Indigenous Uses, Phytochemical Analysis, and Anti-Inflammatory Properties of Australian Tropical Medicinal Plants

Antifungal Activity and Potential Action Mechanism of Allicin against Trichosporon asahii

Discovery of Drug Candidates for Specific Human Disease Based on Natural Products of Gut Microbes

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