Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

Ashrafizadeh, Milad; Aref, Amir Reza; Sethi, Gautam; Ertas, Yavuz Nuri; Wang, Lu

doi:10.1016/j.jnutbio.2024.109647

Cited by 3 publications

(1 citation statement)

References 221 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Natural extracts and their bioactive compounds have recently gained recognition as potential lead molecules in drug discovery for cancer treatment ( 159 , 160 ). They offer an alternative to chemical synthetic drugs, potentially minimizing toxic side effects and holding promise for enhancing clinical anti-tumor therapy.…”

Section: Role Of Gsh-degrading Enzymes In Medicinementioning

confidence: 99%

Glutathione‑degrading enzymes in the complex landscape of tumors (Review)

Zhang,

Yao2,

Zhou

et al. 2024

Int J Oncol

View full text Add to dashboard Cite

Glutathione (GSH)-degrading enzymes are essential for starting the first stages of GSH degradation. These enzymes include extracellular γ-glutamyl transpeptidase (GGT) and intracellular GSH-specific γ-glutamylcyclotransferase 1 (ChaC1) and 2. These enzymes are essential for cellular activities, such as immune response, differentiation, proliferation, homeostasis regulation and programmed cell death. Tumor tissue frequently exhibits abnormal expression of GSH-degrading enzymes, which has a key impact on the development and spread of malignancies. The present review summarizes gene and protein structure, catalytic activity and regulation of GSH-degrading enzymes, their vital roles in tumor development (including regulation of oxidative and endoplasmic reticulum stress, control of programmed cell death, promotion of inflammation and tumorigenesis and modulation of drug resistance in tumor cells) and potential role as diagnostic biomarkers and therapeutic targets. Contents 1. Introduction 2. Extracellular and intracellular GSH-degrading enzymes 3. GSH-degrading enzymes in tumorigenesis and progression 4. Role of GSH-degrading enzymes in medicine 5. Conclusion

show abstract

Section: Role Of Gsh-degrading Enzymes In Medicinementioning

confidence: 99%

Glutathione‑degrading enzymes in the complex landscape of tumors (Review)

Zhang,

Yao2,

Zhou

et al. 2024

Int J Oncol

View full text Add to dashboard Cite

show abstract

Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways

Guo,

Huang,

Hou

et al. 2024

Cancer Reports

View full text Add to dashboard Cite

BackgroundIn recent decades, natural compounds have been considered a significant source of new antitumor medicines due to their unique advantages. Several in vitro and in vivo studies have focused on the effect of terpenoids on apoptosis mediated by mitochondria in malignant cells.Recent findingsIn this review article, we focused on six extensively studied terpenoids, including sesquiterpenes (dihydroartemisinin and parthenolide), diterpenes (oridonin and triptolide), and triterpenes (betulinic acid and oleanolic acid), and their efficacy in targeting mitochondria to induce cell death. Terpenoid‐induced mitochondria‐related cell death includes apoptosis, pyroptosis, necroptosis, ferroptosis, autophagy, and necrosis caused by mitochondrial permeability transition. Apoptosis and autophagy interact in meaningful ways. In addition, in view of several disadvantages of terpenoids, such as low stability and bioavailability, advances in research on combination chemotherapy and chemical modification were surveyed.ConclusionThis article deepens our understanding of the association between terpenoids and mitochondrial cell death, presenting a hypothetical basis for the use of terpenoids in anticancer management.

show abstract

In Vitro Protective Effects of a Standardized Extract of Opuntia ficus-indica (L.) Mill. Cladodes and Olea europaea L. Leaves Against Indomethacin-Induced Intestinal Epithelial Cell Injury

Salamone,

Molonia,

Muscarà

et al. 2024

Antioxidants

View full text Add to dashboard Cite

Nonsteroidal anti-inflammatory drugs (NSAIDs) can induce serious adverse effects in gastrointestinal (GI) mucosa, increasing intestinal permeability and leading to mitochondrial dysfunction, oxidative stress, apoptosis and inflammation. As proton pump inhibitors are effective in protecting against NSAID-induced gastropathy but not NSAID-induced enteropathy, current research is focused on natural products as protective substances for therapy and prevention of intestinal injury. Herein, through the use of an in vitro model based on intestinal epithelial cell (Caco-2) damage caused by indomethacin (INDO), we examined the protective activity of a commercially available standardized extract (OFI+OE) from Opuntia ficus-indica (L.) Mill. cladodes and Olea europaea L. leaves. Pre-treatment with OFI+OE prevented INDO-induced intestinal epithelial barrier damage, as demonstrated by TEER measurement, fluorescein permeability, and tight junction protein expression. The extract showed positive effects against INDO-induced oxidative stress and correlated activation of apoptosis, decreasing pro-apoptotic markers BAX and Caspase-3 and increasing anti-apoptotic factor Bcl-2. Moreover, the extract inhibited the NF-κB pathway and pro-inflammatory cascade. In conclusion, these data support the use of OFI+OE extract as a natural strategy for therapy and prevention of intestinal mucosal damage, demonstrating its beneficial effects against INDO-induced intestinal damage, through modulation of oxidative, apoptotic, and inflammatory pathways.

show abstract

Natural product/diet-based regulation of macrophage polarization: Implications in treatment of inflammatory-related diseases and cancer

Cited by 3 publications

References 221 publications

Glutathione‑degrading enzymes in the complex landscape of tumors (Review)

Glutathione‑degrading enzymes in the complex landscape of tumors (Review)

Therapeutic Potential of Terpenoids in Cancer Treatment: Targeting Mitochondrial Pathways

In Vitro Protective Effects of a Standardized Extract of Opuntia ficus-indica (L.) Mill. Cladodes and Olea europaea L. Leaves Against Indomethacin-Induced Intestinal Epithelial Cell Injury

Contact Info

Product

Resources

About