Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Abstract

Herein we designed a collection of trimethyl-lock quinone profluorophores as activity-based probes for imaging NAD(P)H:quinone oxidoreductase (NQO1) in cancer cells and tumour tissues. Profluorophores were prepared via synthetic routes from naturally-occurring quinones and characterised in vitro using recombinant enzymes, to be further validated in cells and fresh frozen canine tumour tissues as potential new tools for cancer detection and imaging.

Structure-based identification of naphthoquinones and derivatives as novel inhibitors of main protease Mpro and papain-like protease PLpro of SARS-CoV-2

“…The phenazine form of the triazole compounds and quinones described in groups 1 and 3 were also evaluated in group 5 [94][95][96][97]. Group 6 is the most complete and diverse group addressed in this study, containing approximately two hundred 1,4naphthoquinones with broad substitution patterns in the benzenoid A-ring and B-ring.…”

Recent Advances in the Fluorescent Probes for Flavinase Activity: Design and Applications

“…In the same year, Marc Vendrell and coworkers designed a new class of heterocyclic compounds for the detection of NQO1 activity in tumor tissues. [34] Probe 18 (Figure 11) was developed and designed by combining nitrogen-containing fluorescent heterocycles with trimethyl-locked quinone propionate groups. [35] It was used to detect fresh frozen dog samples of healthy and adenocarcinoma colon, and showed that tumor tissue exhibited brighter green fluorescence than healthy tissue.…”

“…It is a potential to be as practical tool for the early detection and diagnosis of cancer. In the same year, Marc Vendrell and coworkers designed a new class of heterocyclic compounds for the detection of NQO1 activity in tumor tissues [34] . Probe 18 (Figure 11) was developed and designed by combining nitrogen‐containing fluorescent heterocycles with trimethyl‐locked quinone propionate groups [35] .…”

Correction: A highly selective fluorescent probe for human NAD(P)H:quinone oxidoreductase 1 (hNQO1) detection and imaging in living tumor cells

“…The missing references are listed below as ref. [1][2][3][4][5][6], and should be cited in the original paper at the end of the following sentence on page 26729:…”

“…Herein, we designed and synthesized a novel uorescent probe 1 for detection of hNQO1 based on TCF-OH as a chromophore and quinone propionic acid (QPA) as a recognition group. [1][2][3][4][5][6] The authors sincerely apologise for this oversight. The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.…”