Natural product medicines: A literature update

Dar, Refaz Ahmad; Shahnawaz, Mohd.; Rasool, Saika; Qazi, Parvaiz Hassan

doi:10.31254/phyto.2017.6606

Cited by 31 publications

(17 citation statements)

References 8 publications

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“…The progress in plant tissue culture, sophisticated extraction, isolation and characterization tools, and modern biotechnological approaches have simplified the production and standardization of herbal medicines, to elucidate analytical marker compounds [ 13 , 14 ]. Natural products such as prostaglandins, steroids, and peptides hormones play a vital role in the pharmaceutical industries to boost the inspiration for drug discovery during the 20 th century [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Antioxidant and Antibacterial Activity of Different Solvent Extracts of Beilschmiedia roxburghiana Nees Stem Barks

Khanal

Sharma

Pokharel

et al. 2022

The Scientific World Journal

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Plants have long been considered as a basis of medicines for different indigenous cultures around the globe. They continue as a prominent source of important phytoconstituents which exhibit significant biological activities. In this study, we performed the phytochemical screening, estimation of total phenolic and flavonoids, antioxidants, and antimicrobial activities of the stem bark of Beilschmiedia roxburghiana Nees using different solvents. The total phenolic and total flavonoid contents ranged from 106.73 ± 1.62 mg GAE/g and 99.32 ± 0.66 mg QE/g (methanol extract) to 65.59 ± 1.79 mg GAE/g and 29.98 ± 0.90 mg QE/g (n-hexane extract), respectively. The maximum 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity with a half-maximal inhibitory concentration (IC50) of 39.86 ± 3.69 μg/mL was observed for methanol extract followed by aqueous (IC50 = 43.55 ± 6.16 μg/mL), ethyl acetate (IC50 = 44.30 ± 5.88 μg/mL), dichloromethane (IC50 = 71.50 ± 4.70 μg/mL), and the lowest activity was observed for n-hexane extract. The disc diffusion method revealed that the ethyl acetate extract exhibited relatively higher activity against Salmonella typhi (ZOI = 13 mm), and moderate activities against Shigella sonnei, Acinetobacter baumannii, Klebsiella pneumoniae, and Staphylococcus aureus (ZOI = 12 mm). The methanol and aqueous extracts showed nearly parallel and the n-hexane and dichloromethane extracts exhibited mild antibacterial activities. The results indicated that the polarity index of the extracting solvents amplified the biological activities of the extract. The study is helpful to support the validity of the traditional application of the plant as natural medicine.

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Section: Introductionmentioning

confidence: 99%

Phytochemical Analysis and In Vitro Antioxidant and Antibacterial Activity of Different Solvent Extracts of Beilschmiedia roxburghiana Nees Stem Barks

Khanal

Sharma

Pokharel

et al. 2022

The Scientific World Journal

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“…The annual growth rates are still about 5-7% due to the common trend in natural products [43,60]. Even so, about 5% of active pharmaceutical ingredients are natural and about 23% are of natural origin with synthetic modifications [61]. Germany has about 12,000 ha of medicinal plant cultivation areas, which need to be increased towards 20,000 ha as 80% of the country's raw material is imported with about 750 companies involved [62,63].…”

Section: Overview and Current State Of Botanicalsmentioning

confidence: 99%

Technical Potential for Energy and GWP Reduction in Chemical–Pharmaceutical Industry in Germany and EU—Focused on Biologics and Botanicals Manufacturing

2020

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European policy demands climate neutrality by the year 2050. Therefore, any manufacturing optimization needs to be achieved in the well-known pareto of global warming potential (GWP) reduction combined with cost of goods (COG) reduction at increasing product amounts, while still being able to compete in the world market. The chemical–pharmaceutical industry is one of the most energy-intensive industries. The pharmaceutical industry operates with low batch sizes, but high margins. This study analyzes, based on the literature and Bundesministerium für Wirtschaft und Energie (BMWi; English: Federal Ministry for Economic Affairs and Energy)-funded project results, the technical potentials for energy and GWP reduction, while focusing on biologics and botanicals, because those are already widely based on natural raw material resources. The potential impact for green technologies is pointed out in relation to climate-neutral manufacturing.

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“…[7] Plant-based systems continue to play a vital role in basic healthcare because medicinal plants are key reservoirs of chemical compounds with excellent therapeutic impact on human health and 80 % of the world population today rely majorly on medicines derived essentially from plants for health care which are mostly supplanted by pharmaceutical constituents in the world. [10][11][12] Therefore, there is need for continuous exploration of medicinal plant that are highly rich in phytochemicals and are known to possess anti-inflammatory and anti-oxidant properties such as S. longepedunculata in continuous investigation for potential as wound healing agent with outstanding therapeutic action, zero side effect, quick accessibility and cost effective. [1,5] Securidaca longepedunculata commonly called violet tree in English is a quick growing evergreen plant up to 12 m high and is usually found in woodlands and savannah habitat in Africa, Asia and some European countries.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Wound‐Healing Activity ofSecuridaca longepedunculataRoot Extract in Male Wistar Rats

2022

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Wound‐healing is a complex series of well‐coordinated cellular and biochemical happenings that reinstates the skin‘s integrity. Medicinal herbs offer a promising alternative than synthetic medications for wound‐healing because they have fewer adverse effects. This present study aims to evaluate wound‐healing potential of methanol extract of S. longepedunculata root (MESLR) in male rats. Some biological activities as well as phytochemical analysis were also carried out to elucidate the rationale of its wound‐healing potency. Alkaloids, flavonoids and terpenoids were found to be present amongst others with the saponin content being the chief [(22.80±0.87) g/100 g]. MESLR had a greater potential inhibiting the DPPH radicals at IC50 of 5.5 μg/ml and % free radical inhibition of 86.03 % as well as the highest inhibiting potential 54.34 % in the anti‐inflammatory study. 100 % wound closure (p< 0.05) was observed with 2.0 g/10 g MESLR based‐ointment as against the negative control group before the 21st day while the subsequent groups and the standard treatment showed complete closure on the last day of the experiment. The histological examination showed more collagen formation, less inflammatory cell, increased fibroblast distribution, and keratin synthesis in all the groups except for the negative control group, which on the 21st day of the study demonstrated epithelial necrosis and severe epidermal deterioration. The foundational information presented from this study suggests the efficacy of S. longepedunculata for topical management and treatment of wounds in traditional medicine and this report is the earliest study of the use of S. longepedunculata root for wound‐healing.

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Natural product medicines: A literature update

Cited by 31 publications

References 8 publications

Phytochemical Analysis and In Vitro Antioxidant and Antibacterial Activity of Different Solvent Extracts of Beilschmiedia roxburghiana Nees Stem Barks

Phytochemical Analysis and In Vitro Antioxidant and Antibacterial Activity of Different Solvent Extracts of Beilschmiedia roxburghiana Nees Stem Barks

Technical Potential for Energy and GWP Reduction in Chemical–Pharmaceutical Industry in Germany and EU—Focused on Biologics and Botanicals Manufacturing

Evaluation of Wound‐Healing Activity ofSecuridaca longepedunculataRoot Extract in Male Wistar Rats

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