Natural Products and some Semi-synthetic Analogues as Potential TRPV1
Ligands for Attenuating Neuropathic Pain

Naik, Gaurav Gopal; Uniyal, Ankit; Chouhan, Deepak; Tiwari, Vinod

doi:10.2174/1389201022666210719155931

Cited by 20 publications

(7 citation statements)

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“…Gaurav G-N et al recently showed that natural products and some semi-synthetic analogs as potential TRPV1 ligands for attenuating neuropathic pain. 25 Akhilesh et al reviewed Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain. 5 Pathogenic sensitization of TRPV1 is characterized by a decrease in the activation threshold and an increase in responsiveness.…”

Section: Discussionmentioning

confidence: 99%

TRPV1 and GABAB1 in the Cerebrospinal Fluid-Contacting Nucleus are Jointly Involved in Chronic Inflammatory Pain in Rats

Xu¹,

Yan²,

Yuan³

et al. 2022

JPR

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Objective To assess the receptors of TRPV1 and GABA B1 receptors that were colocalized in cerebrospinal fluid contacting nucleus (CSF-contact nucleus) of chronic inflammatory pain (CIP) rats bringing inspiration for reducing chronic pain. Methods A rat model of CIP was constructed by plantar injection of complete Freund’s adjuvant (CFA), and the paw withdrawal mechanical threshold (PWMT) and paw withdrawal thermal latency (PWTL) were measured 1, 3, 5, 7, 10, and 14 days after plantar injection. In the first part of the experiment, rats with CIP were divided into the immunofluorescence group and the coimmunoprecipitation (Co-IP) group (n = 6). Rats in the immunofluorescence group were injected with the retrograde tracer CB conjugated with Alexa Fluor 594 into the lateral ventricle two days before the injection of CFA into the plantar surface of the left paw. Three days later, rats that exhibited hyperalgesia were perfused, and their brains were extracted and used for double immunofluorescence staining of the CSF-contacting nucleus. Rats in the Co-IP group were anesthetized and dissected 3 days after CFA injection, and fresh brain segments containing the CSF-contacting nucleus were collected for Co-IP to assess the colocalization of TRPV1 and GABA B1 in the CSF-contacting nucleus (n = 6). In the second part of the experiment, SD rats were divided into the normal saline group (control group) and the CFA group. Fresh CSF-contacting nucleus-containing tissues were collected for Western blot analysis 3 days after plantar injection to observe the changes in TRPV1 and GABA B1 expression in the CSF-contacting nucleus. Results TRPV1 and GABA B1 were co-expressed in the CSF-contacting nucleus in rats with CIP, and their expression was upregulated. Conclusion TRPV1 and GABA B1 in the CSF-contacting nucleus are jointly involved in CIP in rats, and there is a direct or indirect link between TRPV1 and GABA B1 .

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Section: Discussionmentioning

confidence: 99%

TRPV1 and GABAB1 in the Cerebrospinal Fluid-Contacting Nucleus are Jointly Involved in Chronic Inflammatory Pain in Rats

Xu¹,

Yan²,

Yuan³

et al. 2022

JPR

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“…Various plant-derived compounds such as capsaicin, curcumin, salicin and triptolide have been reported to provide pharmacotherapeutic activities against neuropathic pain. [12][13][14][15] These substances have preferred to synthetic drugs due to their less complication and fewer side effects as well as can confer several actions/effects concurrently such as anti-oxidant activity, anti-inflammatory, neuroprotective, modulation of pain management systems (opioids, serotonergic and cannabinoid systems) and ion channels. 15 Naringin, 4′,5,7-trihydroxyflavanone-7-rhamnoglucoside, is one of the main bioactive polyphenols derived from grape fruit and related citrus species.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury

Safari,

Fakhri,

Maleki

et al. 2024

Journal of Bioactive and Compatible Polymers

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Peripheral neuropathies are associated with various detrimental complications, leading to life-debilitating disorders, including neuropathic pain. Hence, the current study aimed to incorporate naringin, a potential natural component, into chitosan nanoparticles (NPs) to ameliorate the complications resulting from chronic constriction injury (CCI) induced painful neuropathy. The prepared NPs had a particle size of 220 nm and PDI = 0.37, with relatively spherical morphology and zeta potential of +41.5 mV. The relevant analyses indicated the loading and high encapsulation efficiency of naringin into the NPs as well as a prolonged release of naringin. The anti-neuropathic evaluations of chronic constriction injury (CCI)-induced rats treated with naringin-loaded NPs (10 mg/kg) remarkably ameliorated hyperalgesia and cold allodynia. In addition, the treatment with naringin-loaded NPs led to improvements in sensory and locomotor impairment, as evidenced by changes in behavioral parameters such as reduced paw licking, increased rearings, and enhanced crossings. The NPs treatment significantly attenuated the elevated levels of nitrite and restored the reduced glutathione level in the serum of CCI-induced rats. Moreover, histopathological analysis exhibited regeneration of the sciatic nerve injury through reducing myelin degeneration, axonal swelling, and nerve fiber derangement. Therefore, these findings suggest that the naringin-loaded chitosan NPs has promising pharmacological activities for the treatment of neuropathic pain sufferers.

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“…In addition to oxidative stress, another feature of TRPV1 channels is that they can be activated by excessive temperature (T > 43°C) (Caterina et al, 1997; Naziroǧlu, 2012). It can also be activated by chemicals such as capsaicin, anandamide, resiniferatoxin and by environmental irritants such as camphor and allicin (Naik et al, 2022). The most effective antagonists on TRPV1 channels are capsazepine, 5′‐iodoreziniferatoxin, ruthenium red and various antioxidants (Wong & Gavva, 2009).…”

Section: Introductionmentioning

confidence: 99%

Downregulation of TRPM7, TRPM8, and TRPV1 channels modulate apoptotic parameters and neurodegenerative markers: Focus on neuronal differentiation and Parkinson's disease model

Öz

Çelik

2023

Cell Biology International

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The transient receptor potential channel (TRP) channels are expressed in neuronal tissues and involved in neurological diseases such as pain, epilepsy, neuronal apoptosis, and neurodegenerative diseases. Formerly, we have investigated how neuronal differentiation changes TRP channels expression profile and how Parkinson's disease model is related with this expression levels. We have found that transient receptor potential channel melastatin subtype 7 (TRPM7), transient receptor potential channel melastatin subtype 8 and transient receptor potential channel vanilloid subtype 1 (TRPV1) channels have pivotal effects on differentiation and 1‐Methyl‐4‐phenylpyridinium (MPP+)‐induced Parkinson's disease model in SH‐SY5Y cells. In this study, we have investigated that downregulation of the TRP channels to evaluate how differentiation status changes to Parkinson's disease pathological hallmarks. We have also performed to other analyses to elucidate these TRP channels' function in MPP+‐induced neurotoxicity related apoptosis, cell viability, caspase 3 and 9 enzyme activities, intracellular reactive oxygen species production, mitochondrial depolarization levels, Ca2+ signaling, Alpha‐synuclein and Dopamine levels, mono amino oxidase A and B enzymatic activities, both in differentiated and undifferentiated neuronal cells. Herein we have concluded that especially TRPM7 and TRPV1 channels have distinct role in Parkinson's disease pathology via their activity changings in pathological state, and downregulation of these channels or specific antagonists can be useful for the possible treatment strategy for Parkinson's disease and related markers.

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Natural Products and some Semi-synthetic Analogues as Potential TRPV1 Ligands for Attenuating Neuropathic Pain

Cited by 20 publications

References 0 publications

TRPV1 and GABAB1 in the Cerebrospinal Fluid-Contacting Nucleus are Jointly Involved in Chronic Inflammatory Pain in Rats

TRPV1 and GABAB1 in the Cerebrospinal Fluid-Contacting Nucleus are Jointly Involved in Chronic Inflammatory Pain in Rats

Evaluating the anti-neuropathic effects of naringin-loaded chitosan nanocarriers in a murine model of constriction injury

Downregulation of TRPM7, TRPM8, and TRPV1 channels modulate apoptotic parameters and neurodegenerative markers: Focus on neuronal differentiation and Parkinson's disease model

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