Natural products as a therapy to combat against SARS-CoV-2 virus infection

COVID-19 associated thyroid dysfunction and other comorbidities and its management using phytochemical-based therapeutics: a natural way

“…There were no variations in FT4 levels recorded [ 144 ]. Lui et al found similar findings, stating that the decline of FT3 levels linked with systemic inflammation appeared to be connected to the clinical worsening of symptoms in patients, although TSH and FT4 levels were not significantly affected [ 123 ]. Zou et al found significantly low FT3 levels in 27.5 percent of COVID-19 patients; these were older females patients with more severe symptoms including fever and dyspnea [ 146 ].…”

“…This study concluded that SARS-CoV-2 infection could affect thyroid function directly which could lead to manifestations like exacerbating pre-existing autoimmune thyroid illness. Low FTP levels linked to systemic inflammation may also have prognostic implications [ 123 ].…”

“…Zou et al found significantly low FT3 levels in 27.5 percent of COVID-19 patients; these were older females patients with more severe symptoms including fever and dyspnea [ 146 ]. The low TT3 or FT3 levels associated with thyroid dysfunction are common in severe clinical situations and are referred to as non-thyroidal illness syndrome (NTI) or ESS [ 123 ].…”

“…Enhanced CRP levels were independently correlated with low FT3 levels in Lui et al studies as well as greater procalcitonin levels in Zou et al investigations. Gao et al investigated whether thyroid hormone levels could predict mortality in COVID-19 patients with severe symptoms [ 123 , 144 , 146 ]. Higher FT3 levels were linked to a lower risk of all-cause mortality, according to the researchers.…”