Natural products as pesticides: Two examples of stereoselective synthesis

Früh, Thomas; Chemla, Philippe; Ehrler, J.; Farooq, Saleem

doi:10.1002/(sici)1096-9063(199601)46:1<37::aid-ps339>3.0.co;2-k

Cited by 23 publications

(9 citation statements)

References 55 publications

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“…Studies even show that use of Streptomycetes enhances growth of the crop plants [6] . The search for new principles in biocontrol of plant pathogens different from the classical used fungicides, is of world wide concern [7][8][9] . Biological control of plant diseases is slow, gives few quick profits, but can be long lasting, inexpensive and harmless to life.…”

Section: Introductionmentioning

confidence: 99%

Biological Control of Rice Blast (Magnaporthe oryzae) by use of Streptomyces sindeneusis isolate 263 in Greenhouse

Zarandi¹

2009

American Journal of Applied Sciences

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Soil Actinomycetes particularly Streptomyces spp. have antagonistic activity against wide range of plant pathogens. In the recent decades they have attracted high interests as biocontrol agents. In search for finding such principles, in vitro suppression of Magnaporthe oryzae the causal agent of rice blast disease was studied by use of Streptomyces sindeneusis isolate 263 in greenhouse. Spray of rice seedling-leaves with of mixed spore suspension of the pathogen and S. sindeneusis isolate 263 resulted in strong inhibition of the pathogen and suppression of leaf symptoms. Propagation of the antagonist crude sap was performed in aqueous cultures and bioactivity was monitored in shaked cultures. Ongoing goals of this research include isolation, characterization and identification of the active metabolites and future goals include identification of active genes for use in development of recombinant DNAs in transgenic rice varieties bearing elevated resistance to infections by M. oryzae.

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Section: Introductionmentioning

confidence: 99%

Biological Control of Rice Blast (Magnaporthe oryzae) by use of Streptomyces sindeneusis isolate 263 in Greenhouse

Zarandi¹

2009

American Journal of Applied Sciences

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“…It has been suggested that microbial metabolites may offer new chemical structures with new modes of action which render them less prone to cross‐resistance with commercial fungicides 3. 4 In addition, many such metabolites are readily degraded, often within a few days, in agricultural systems, thus offering the distinct advantage of reduced residual potential for possible harmful side‐effects on non‐target organisms3 in conjunction with effective disease control.…”

Section: Introductionmentioning

confidence: 99%

In vivo control andin vitro antifungal activity of rhamnolipid B, a glycolipid antibiotic, againstPhytophthora capsici andColletotrichum orbiculare

2000

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The glycolipid antibiotic rhamnolipid B isolated from Pseudomonas aeruginosa strain B5 was evaluated for in vitro antifungal activity and in vivo control against phytophthora blight and anthracnose under glasshouse conditions. Rhamnolipid B showed antifungal activity against Cercospora kikuchii, Cladosporium cucumerinum, Colletotrichum orbiculare, Cylindrocarpon destructans, Magnaporthe grisea and Phytophthora capsici. Microscopic observation revealed that the high level of antifungal activity (10 mg ml À1 ) against P capsici was mainly due to a lytic effect on zoospores. Zoospore lysis began in the presence of 10 mg ml À1 of rhamnolipid B and most of the zoospores were collapsed at 25 mg ml À1 . Rhamnolipid B showed inhibitory activity against the germination of zoospores and hyphal growth of P capsici at concentrations of 50 mg ml À1 . Spore germination of the anthracnose plant pathogen C orbiculare was also inhibited in the presence of 50 mg ml À1 of rhamnolipid B, although hyphal growth was not affected at this concentration. In the glasshouse, the ef®cacy of rhamnolipid B against phytophthora blight was similar to that of metalaxyl on pepper plants when treated just before inoculation with P capsici. Treatment with either at 500 mg ml À1 completely protected pepper plants from phytophthora blight. Rhamnolipid B also suppressed the development of C orbiculare infection on leaves of cucumber plants.

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“…Microbial metabolites are still attractive for fungicide development because of the variability in chemical structures and the chance that a newly discovered antifungal microbial metabolite could have a new mode of action and no cross-resistance to commercial fungicides (Fruh et al, 1996;Porter, 1985;Yarbrough et al, 1993). Also, effective compounds of natural origin are expected to be more advantageous than synthetic pesticides, as they have generally a lower environmental impact and are easily biodegradable.…”

Section: Introductionmentioning

confidence: 99%

Production of nigericin and niphimycin by soil isolate Streptomyces sp. MS1: Anti-Candida bioassay guided response surface methodology for the optimized culture medium

Mojićević

Grahovac

Petković³

et al. 2017

Facta Univ Phys Chem Technol

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Anti-Candida bioassay guided optimization of the culture medium was used in order to enhance the antifungal activity of the soil isolate MS1. Its morphological, physiological and biochemical characteristics, as well as 16S rDNA sequencing, assigned an MS1 isolate to genus Streptomyces. Optimization of the culture medium was achieved by experimental factorial design and response surface methodology. Maximal antifungal components production was obtained with starch, soybean meal and phosphates content of 40.52, 5.10 and 2.21 g/L, respectively. Chromatography and 1H and 13CNMR spectroscopy were employed for purification and structural characterization of antifungal antibiotics concurrently produced by this strain. These antibiotics were identified as polyether carboxylic antibiotic nigericin and guanidyl-polyol macrolide, niphimycin.

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Natural products as pesticides: Two examples of stereoselective synthesis

Abstract: Abstract:The strategy and synthetic efforts leading to efficient stereoselective syntheses of thiangazole, a tris-thiazolinyl-oxazole metabolite isolated from Polyangium spp., and of hydantocidin, a spironucleoside metabolite isolated from Streptomyces hygroscopicus, are discussed.

Cited by 23 publications

References 55 publications

Biological Control of Rice Blast (Magnaporthe oryzae) by use of Streptomyces sindeneusis isolate 263 in Greenhouse

Biological Control of Rice Blast (Magnaporthe oryzae) by use of Streptomyces sindeneusis isolate 263 in Greenhouse

In vivo control andin vitro antifungal activity of rhamnolipid B, a glycolipid antibiotic, againstPhytophthora capsici andColletotrichum orbiculare

Production of nigericin and niphimycin by soil isolate Streptomyces sp. MS1: Anti-Candida bioassay guided response surface methodology for the optimized culture medium

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