Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010

Lin, Qian-Ru; Jia, Lian-Qun; Lei, Ming; Gao, Di; Zhang, Nan; Sha, Lei; Liu, Xu-Han; Liu, Yu-Dan

doi:10.1016/j.phrs.2023.107054

Cited by 5 publications

(1 citation statement)

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“…The characteristic of mitochondria dysfunction in β-cells is associated with an increase in reactive oxygen species generation, a decrease in mitochondria ATP synthesis and antidromic intracellular Ca 2+ levels (Onikanni et al, 2023). It seems that the use of natural antioxidant compounds by improving mitochondrial function can be effective in reducing the damage caused by various agent (diabetogenic) in pancreatic β-cells, especially natural compounds with antiprediabetic or antidiabetic properties (Lin et al, 2024). Among of natural compounds, hesperidin (a citrus bioflavonoid), vanillic acid (a bioactive compound derived from natural sources such as vegetables, fruits and plant), and sinapic acid (a natural phenolic acid found in fruits, vegetables, and cereals,) exhibit many beneficial effects such as antidiabetic, antioxidative, anti-inflammatory, and mitochondrial protective activities, which these properties are in the same direction to prevent and improve function of β-cells in prediabetic and diabetic condition (Akiyama et al, 2010;Pandi & Kalappan, 2021;Singh et al, 2022;Tian et al, 2021;Vinothiya & Ashokkumar, 2017;Zych et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Hesperidin, vanillic acid, and sinapic acid attenuate atorvastatin‐induced mitochondrial dysfunction via inhibition of mitochondrial swelling and maintenance of mitochondrial function in pancreas isolated mitochondria

Salimi,

Khezri,

Vahabzadeh

et al. 2024

Drug Development Research

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It has been reported that lipophilic statins such as atorvastatin can more readily penetrate into β‐cells and reach the mitochondria, resulting in mitochondrial dysfunction, oxidative stress, decrease in insulin release. Many studies have shown that natural products can protect mitochondrial dysfunction induced by drug in different tissue. We aimed to explore mitochondrial protection potency of hesperidin, vanillic acid, and sinapic acid as natural compounds against mitochondrial dysfunction induced by atorvastatin in pancreas isolated mitochondria. Mitochondria were isolated form rat pancreas and directly treated with toxic concentration of atorvastatin (500 µM) in presence of various concentrations hesperidin, vanillic acid, and sinapic acid (1, 10, and 100 µM) separately. Mitochondrial toxicity parameters such as the reactive oxygen species (ROS) formation, succinate dehydrogenases (SDH) activity, mitochondrial swelling, depletion of glutathione (GSH), mitochondrial membrane potential (MMP) collapse, and malondialdehyde (MDA) production were measured. Our findings demonstrated that atorvastatin directly induced mitochondrial toxicity at concentration of 500 μM and higher in pancreatic mitochondria. Except MDA, atorvastatin caused significantly reduction in SDH activity, mitochondrial swelling, ROS formation, depletion of GSH, and collapse of MMP. While, our data showed that all three protective compounds at low concentrations ameliorated atorvastatin‐induced mitochondrial dysfunction with the increase of SDH activity, improvement of mitochondrial swelling, MMP collapse and mitochondrial GSH, and reduction of ROS formation. We can conclude that hesperidin, vanillic acid, and sinapic acid can directly reverse the toxic of atorvastatin in rat pancreas isolated mitochondria, which may be beneficial for protection against diabetogenic‐induced mitochondrial dysfunction in pancreatic β‐cells.

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