Natural Products-Based Botanical Bactericides Discovery: Novel Abietic Acid Derivatives as Anti-Virulence Agents for Plant Disease Management

Qi, Pu-Ying; Zhang, Taihong; Wang, Na; Yang, Feng; Zhang, Dan; Shao, Wu-Bin; Meng, Jiao; Liu, Liwei; Jin, Linhong; Zhang, Heng; Zhou, Xiang; Yang, Song

doi:10.1021/acs.jafc.2c08392

Cited by 14 publications

(3 citation statements)

References 48 publications

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“…Biofilms can effectively reduce bacterial penetration and enhance resistance to host immune responses, ultimately leading to bacterial drug resistance, including resistance to insecticides. 38 To delve deeper into the impact of compound W2 on Xoo's ability to form biofilms, a biofilm assay was conducted. As illustrated in Fig.…”

Section: Effects Of Various Dosages Of Compound W2 On Biofilmmentioning

confidence: 99%

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

Wang,

Li,

Zhu

et al. 2024

Pest Management Science

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BACKGROUNDXanthomonas oryzae pv. oryzae (Xoo) is often considered one of the most destructive bacterial pathogens causing bacterial leaf blight (BLB), resulting in significant yield and cost losses in rice. In this study, a series of novel derivatives containing the isopropanolamine moiety linked to various substituted phenols and piperazines were designed, synthesized and screened.RESULTSAntibacterial activity results showed that most compounds had good inhibitory effects on Xoo, among which compound W2 (EC50 = 2.74 μg mL−1) exhibited the most excellent inhibitory activity, and W2 also had a certain curative effect (35.89%) on rice compared to thiodiazole copper (TC) (21.57%). Scanning electron microscopy (SEM) results indicated that compound W2 could cause rupture of the Xoo cell membrane. Subsequently, proteomics and quantitative real‐time polymerase chain reaction revealed that compound W2 affected the physiological processes of Xoo and may exert antibacterial activity by targeting the two‐component system pathway. Interestingly, W2 upregulated Xoo's methyltransferase to impact on its pathogenicity.CONCLUSIONThe present study offers a promising phenolic‐piperazine‐sopropanolamine compound as an innovative antibacterial strategy by specifically targeting the two‐component system pathway and inducing upregulation of methyltransferase to effectively impact Xoo's pathogenicity. © 2024 Society of Chemical Industry.

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Section: Effects Of Various Dosages Of Compound W2 On Biofilmmentioning

confidence: 99%

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

Wang,

Li,

Zhu

et al. 2024

Pest Management Science

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“…Plant extracts or derivatives can be used as less hazardous natural antimicrobials as they tend to be less toxic, and their residues are rapidly biodegraded. Although bio-products have some challenges, including field validation of experimental formulations, these do not prevent the use of natural products for plant disease management [55][56][57].…”

Section: Antifungal Activity Against Phytophthora Infestans and Neope...mentioning

confidence: 99%

In Vitro Antimicrobial Activity of Plant Species against the Phytopathogens Ralstonia solanacearum, Phytophthora infestans, and Neopestalotiopsis javaensis

Ordóñez,

Ruano,

Avila

et al. 2023

Agriculture

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Plants are prone to be attacked by various pathogenic microorganisms, leading to significant crop yield losses. Pesticides are used to control agricultural pathogens; however, frequently, they are toxic synthetic products. This work evaluated the antibacterial and antifungal activity of Pernettya prostrata, and Rubus roseus plant extracts against three phytopathogens Ralstonia solanacearum, Phytophthora infestans, and Neopestalotiopsis javaensis responsible for causing banana bacterial wilt, late blight y scab diseases, respectively. The extracts were obtained in methanol. The phytopathogens were isolated from diseased plants grown in Ecuador, R. solanacearum was isolated from samples of Musa paradiasiaca, P. infestans from samples of Solanum lycopersicum and N. javaensis from diseased samples of Persea americana—morphological and molecular methods identified the isolated pathogens. The antibacterial activity was determined by the microtiter broth dilution method; six serial concentrations of the extracts were tested. The antifungal activity was determined based on the effects of the plant extracts on the inhibition of radial growth of fungi; five serial concentrations of the extracts were tested. The extracts of P. prostrata and R. roseus showed activity against R. solanacearum and P. infestans with a MIC of 22.5 and 31.25 mg/mL, respectively.

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“…In particular, the Xanthomonas oryzae pv. oryzae ( Xoo ) is one of the main culprits of rice diseases and poses a severe threat to worldwide rice quality and yield [ 6 , 7 ]. Various control measures have been used to respond to pathogenic bacterial attacks.…”

Section: Introductionmentioning

confidence: 99%

Discovery of Novel Pentacyclic Triterpene Acid Amide Derivatives as Excellent Antimicrobial Agents Dependent on Generation of Reactive Oxygen Species

Yang

Chen

Wang

et al. 2023

IJMS

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Developing new agricultural bactericides is a feasible strategy for stopping the increase in the resistance of plant pathogenic bacteria. Some pentacyclic triterpene acid derivatives were elaborately designed and synthesized. In particular, compound A22 exhibited the best antimicrobial activity against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac) with EC50 values of 3.34 and 3.30 mg L−1, respectively. The antimicrobial mechanism showed that the compound A22 induced excessive production and accumulation of reactive oxygen species (ROS) in Xoo cells, leading to a decrease in superoxide dismutase and catalase enzyme activities and an increase in malondialdehyde content. A22 also produced increases in Xoo cell membrane permeability and eventual cell death. In addition, in vivo experiments showed that A22 at 200 mg L−1 exhibited protective activity against rice bacterial blight (50.44%) and citrus canker disease (84.37%). Therefore, this study provides a paradigm for the agricultural application of pentacyclic triterpene acid.

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Natural Products-Based Botanical Bactericides Discovery: Novel Abietic Acid Derivatives as Anti-Virulence Agents for Plant Disease Management

Cited by 14 publications

References 48 publications

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

Design, synthesis, antibacterial evaluation of isopropylamine linked with different substituted phenol and piperazine novel derivatives

In Vitro Antimicrobial Activity of Plant Species against the Phytopathogens Ralstonia solanacearum, Phytophthora infestans, and Neopestalotiopsis javaensis

Discovery of Novel Pentacyclic Triterpene Acid Amide Derivatives as Excellent Antimicrobial Agents Dependent on Generation of Reactive Oxygen Species

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