Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin

Feng, Wuwen; Kuang, Shuang-yu; Tu, Can; Ma, Zhi-Jie; Pang, Jing-yao; Wang, Yanhui; Zang, Qingce; Liu, Ta-si; Yan, Zhao; Xiao, Xiaohe

doi:10.1016/j.biopha.2018.01.071

Cited by 50 publications

(37 citation statements)

References 39 publications

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“…Several studies have explored the therapeutic effects of BBR on NASH in murine models (Qiang et al, 2016;He Q. et al, 2017;Zhao et al, 2017;Feng et al, 2018;Luo et al, 2019) and humans (Chang et al, 2016;Wei et al, 2016); Qiang et al demonstrated that demethyleneberberine attenuated lipid accumulation and inflammatory factors secretion with activation of AMPK and inhibition of oxidative stress in MCD diet feeding mice and db/db mice (Qiang et al, 2016). Feng et al compared the effects of BBR, curcumin, and lovastatin on NAFLD rats and found that BBR in combination with curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver than lovastatin (Feng et al, 2018). A meta-analysis included 6ix randomized controlled trials involving 501 patients revealed that BBR has positive efficacy on blood lipids, blood glucose, liver function, insulin resistance, and fatty liver condition of NAFLD patients (Wei et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

Mai

et al. 2020

Front. Pharmacol.

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Berberine (BBR), an isoquinoline alkaloid originating from herbal plants, has been deemed beneficial for non-alcoholic fatty liver disease. Increasing evidence has demonstrated that Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation and the subsequent pyroptosis contribute to the progression of non-alcoholic steatohepatitis (NASH). However, whether BBR impacts NLRP3 inflammasome activation and pyroptosis in NASH and the potential mechanism remains unclear. In the current study, we found that BBR significantly decreased lipid accumulation, ameliorated reactive oxygen species (ROS) and lipid peroxides, Tumor necrosis factor alpha (TNF-a) expression, and phosphorylation of Nuclear factor kappa B (NF-kB) p65 both in vivo and in vitro. In particular, BBR significantly inhibited NLRP3 expression, caspase-1 activity, and the pyroptosis executor, GSDMD-N, expression. In addition, BBR displayed similar inhibitory effects on NLRP3 inflammasome and pyroptosis with a decrease in ROS levels and TXNIP expression as N-acetyl-cysteine, a ROS scavenger, did. Whereas, the inhibitory effect of BBR on ROS, TXNIP expression, NLRP3 inflammasome activation and pyroptosis could be reversed by H 2 O 2 in AML12 cells. This study demonstrates that BBR's inhibitory effect on NLRP3 inflammasome activation and pyroptosis may be mediated by ROS/TXNIP axis in vitro for the first time. Our findings suggest BBR is a potential candidate for the treatment of NASH.

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Section: Discussionmentioning

confidence: 99%

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

Mai

et al. 2020

Front. Pharmacol.

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“…Curcumin treatment could reduce AST and ALP levels in a rat model of NAFLD when compared with the untreated control, 1 and, in comparison to lovastatin therapy. 12 Hypoalbuminemia and hyperbilirubinemia are other abnormalities that are found in cirrhotic-stage of NAFLD patients. 8 In the present study subjects, the albumin and bilirubin levels were within the normal range and curcuminoids + piperine treatment maintained their levels within the normal range.…”

Section: Discussionmentioning

confidence: 99%

Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

Panahi

Valizadegan

Ahamdi

et al. 2019

J of Cellular Biochemistry

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Background Nonalcoholic fatty liver disease (NAFLD) as a prevalent hepatic disease is associated with an increased risk of morbidity and mortality related to the liver and cardiovascular disease (CVD). Lifestyle modification and good metabolic control is the first line of treatment, but not always efficacious in reversing NAFLD pathogenesis. Curcumin is a dietary phytochemical with hepatoprotective activities, though its low bioavailability is considered as a major challenge for clinical applications. Therefore, in this study, in order to improve the bioavailability of curcumin, it was coadministered with piperine and we investigated the effects of this bioavailability‐enhanced curcumin on serum hepatic enzymes, lipid profile, and glycemic indices in patients with NAFLD. Methods In this randomized controlled parallel‐group trial, 70 subjects with ultrasound‐determined NAFLD were randomized to either 500 mg curcuminoids coadministered with 5 mg piperine daily or placebo for 12 weeks. NAFLD severity (on the basis of sonography) and hepatic function was assessed at baseline and at the study end. Results Seventy subjects completed the study. Supplementation with curcuminoids plus piperine significantly reduced the hematocrit (P = 0.027), erythrocyte sedimentation rate (P = 0.048) and the serum concentrations of alanine aminotransferase (P = 0.035), aspartate aminotransferase (P = 0.042), alkaline phosphatase (P = 0.004), cholesterol (P < 0.016), low‐density lipoprotein cholesterol (P < 0.017), Iron (P = 0.026), and Hemoglobin (P = 0.025) and increased total iron‐binding capacity (P = 0.003). However, except albumin, changes in other parameters were not statistically different between groups. In addition, administration of curcuminoids plus piperine significantly improved NAFLD severity (P < 0.001), which was statistically different compared with the placebo group (P = 0.022). Also, the percentage of improved patients was marginally higher in the curcuminoids plus piperine group when compared with the placebo group (P = 0.058). Conclusion This study suggested beneficial effects of combined curcuminoids and piperine supplementation on disease severity in patients with NAFLD.

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“…High-fat diet could lead to abnormal serum lipids by increasing serum TG, serum TC, serum LDL-C levels and decreasing serum HDL-C levels, which caused the formation of hyperlipaemia 13,19 . At present, the effective method in the treatment of the hyperlipemia was taking hypolipidemic, such as lovastatin 7 . Meanwhile, there have been many reports that oil containing unsaturated fatty acid, such as Silkworm pupa oil, Lemongrass oil, Starfish oil and so on 2,17,42 , were beneficial for attenuating hyperlipidemia thereby achieving the same effect as hypolipidemic.…”

Section: Discussionmentioning

confidence: 99%

“…Long-term high-fat diet consumption induced the first sign of NAFLD such as liver injury 7 . Serum ALT and AST levels, the common indicators of liver injury, were measured and the results were shown in Fig.…”

Section: Effect Of Emo On Nafld-related Indicators 341 Effect Of Emmentioning

confidence: 99%

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<i>Elaeagnus mollis</i> Oil Attenuates Non-alcoholic Fatty Disease in High-fat Diet Induced Obese Mice via Modifying the Expression of Lipid Metabolismrelated Genes

et al. 2019

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Natural products berberine and curcumin exhibited better ameliorative effects on rats with non-alcohol fatty liver disease than lovastatin

Cited by 50 publications

References 39 publications

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

Berberine Inhibits Nod-Like Receptor Family Pyrin Domain Containing 3 Inflammasome Activation and Pyroptosis in Nonalcoholic Steatohepatitis via the ROS/TXNIP Axis

Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

<i>Elaeagnus mollis</i> Oil Attenuates Non-alcoholic Fatty Disease in High-fat Diet Induced Obese Mice via Modifying the Expression of Lipid Metabolismrelated Genes

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