Natural Products Chemistry in Marine Ascidians of the Genus Aplidium

Zubı́a, Eva; Ortega, Marı́a J.; Salvá, Javier

doi:10.2174/157019305774322707

Cited by 46 publications

(39 citation statements)

References 52 publications

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“…This rich chemistry is a consequence of their mixed biosynthesis, as they are composed of an aromatic moiety/carbohydrate residue and also a terpenoid portion that can range from one to nine isoprene units. Prenylated quinone/hydroquin one derivatives are amongst the most numerous and widespread in marine environment [63,64]. Meroterpenes are not exclusive to marine organisms, being found also in many terrestrial species.…”

Section: Miscellaneousmentioning

confidence: 99%

Introduction to Anticancer Drugs from Marine Origin

Kim

Kalimuthu

2014

Handbook of Anticancer Drugs From Marine Origin

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The chemical and biological diversity of the marine environment is extraordinary resource for the discovery of new anticancer drugs. Recent technological and methodological advances in elucidation of structure, synthesis, and biological assay have resulted in the isolation and clinical evaluation of various novel anticancer agents from marine pipeline. To understanding the marine derived anticancer compounds are useful in pharmaceutical industry and clinical applications. The marine sponges, algae, microbes, tunicates and other species from the marine pipeline are the important sources for biological active compounds. The past decade has seen a dramatic increase in the number of preclinical anticancer lead compounds from diverse marine life enter human clinical trials.Keywords Anticancer · Algae · Sponges · Marine · Bioactive compounds IntroductionCancer is a dreadful human disease, increasing with changing life style, nutrition, and global warming. A report released by the World Health Organization (WHO) showed that an estimated 12.7 million people were diagnosed with cancer globally and about 7.6 million people died of it in 2008. As estimated in this report, more than 21 million new cancer cases and 13 million deaths are expected by 2030. Although cancer accounts for around 13 % of all deaths in the world, more than 30 % of cancer deaths can be prevented by modifying or avoiding key risk factors [1]. However, almost all of the chemotherapy drugs currently in the market cause serious side effects. Natural products and their derivatives represent more than 50 % of all the drugs in clinical use of the world. Higher plants contribute not less than 25 % of the total. Almost 60 % of drugs approved for cancer treatment are of natural origin.S.-K. Kim and S. Kalimuthu 2 Although marine compounds are underrepresented in current pharmacopoeia, it is anticipated that the marine environment will become an invaluable source of novel compounds in the future [2].Marine nutraceuticals can be derived from a vast array of sources, including marine plants, microorganisms, and sponges. Marine nutraceutical products currently promoted to various countries include fish oil, chitin, chitosan, marine enzymes and chondroitin from shark cartilage, sea cucumbers and mussels. Polysaccharides derived from alga, including alginate, carrageenan and agar are widely used as thickeners and stabilizers in a variety of food ingredients. In addition, Omega PUFA (Polyunsaturated fatty acid) is an important ingredient to the nutraceutical industry [3]. It has been proven that Omega-PUFA, especially eicosapentaenoic acid (EPA) and docosahexenoic acid (DHA) play a significant role in number of aspects of human health [4].More than 70 % of our planet's surface is covered by oceans. An exciting "marine pipeline" of new anticancer clinical and preclinical agents has emerged from intense efforts over the past decade to more effectively explore the rich chemical diversity offered by marine life. The chemical adaptations generally take the form of ...

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Section: Miscellaneousmentioning

confidence: 99%

Introduction to Anticancer Drugs from Marine Origin

Kim

Kalimuthu

2014

Handbook of Anticancer Drugs From Marine Origin

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“…Representative compounds based on the farnesyl quinone/hydroquinone skeleton within marine environment include avarone and avarol from the marine sponge Dysidea avara (Minale et al 1974) and cyclozonarone from the marine brown alga Dictyopteris undulata (Kurata et al 1996). Above all, marine ascidians of the order Aplousobranchiata, family Polyclinidae have been reported to synthesise prenyl quinones and hydroquinones, either linear or cyclic; these metabolites of mixed biogenesis are generally known as meroterpenes and originated from intra-and inter-molecular cyclizations and/or rearrangements, thus giving macrocyclic or policyclic skeletons, often linked to amino acids or taurine residues (Zubìa et al 2005). Indeed, the first biologically active tunicate metabolite, geranylhydroquinone, was isolated from an Aplidium sp.…”

Section: Sulfated Alkanes and Alkenes From Mediterranean Ascidiansmentioning

confidence: 99%

“…(Fig. 3) A. costellatum, and A. antillense, dimeric prenylated quinones from A. longithorax, and chromenols from A. solidum and Amaroucium multiplicatum (Zubìa et al 2005). The Mediterranean ascidian A. conicum has been extensively studied.…”

Section: Sulfated Alkanes and Alkenes From Mediterranean Ascidiansmentioning

confidence: 99%

Antitumor potential of natural products from Mediterranean ascidians

Menna

2009

Phytochem Rev

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Ascidians, invertebrates belonging to the subphylum Urochordata (Tunicata), are renowned for their great chemical diversity, and during the last 25 years, they have been shown to produce an array of cytotoxic molecules. Among the first six marinederived compounds that have reached clinical trials as antitumor agents, three are derived from ascidians, as evidence of the high potential of these organisms as a new source of antitumor compounds. Reported in this communication are some recent results on the chemistry of Mediterranean ascidians; a number of new molecules with different structural features but all endowed with antiproliferative or cytotoxic activity are discussed. These results strongly evidence the highly significant role that Mediterranean ascidians natural products could play in anticancer drug discovery and development process.

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“…A subsequent didemnin B analogue possessing a modified side-chain (see Fig. 17), dehydrodidemnin B (aplidine/plitidepsin), isolated from a Mediterranean tunicate in the Aplidium genus was found to possess greater antitumor activity and improved safety profile [102-104]. …”

Section: Utility In Natural Products De-replication and Drug Discomentioning

confidence: 99%

The utility of metabolomics in natural product and biomarker characterization

Cox

Keasling

et al. 2014

Biochimica et Biophysica Acta (BBA) - General Subjects

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Background Metabolomics is a well-established rapidly developing research field involving quantitative and qualitative metabolite assessment within biological systems. Recent improvements in metabolomics technologies reveal the unequivocal value of metabolomics tools in natural products discovery, gene-function analysis, systems biology and diagnostic platforms. Scope of review We review of some of the prominent metabolomics methodologies employed in data acquisition and analysis of natural products and disease-related biomarkers. Major conclusions This review demonstrates that metabolomics represents a highly adaptable technology with diverse applications ranging from environmental toxicology to disease diagnosis. Metabolomic analysis is shown to provide a unique snapshot of the functional genetic status of an organism by examining its biochemical profile, with relevance toward resolving phylogenetic associations involving horizontal gene transfer and distinguishing subgroups of genera possessing high genetic homology, as well as an increasing role in both elucidating biosynthetic transformations of natural products and detecting preclinical biomarkers of numerous disease states. General significance This review expands the interest in multiplatform combinatorial metabolomic analysis. The applications reviewed range from phylogenetic assignment, biosynthetic transformations of natural products, and the detection of preclinical biomarkers.

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Natural Products Chemistry in Marine Ascidians of the Genus Aplidium

Cited by 46 publications

References 52 publications

Introduction to Anticancer Drugs from Marine Origin

Introduction to Anticancer Drugs from Marine Origin

Antitumor potential of natural products from Mediterranean ascidians

The utility of metabolomics in natural product and biomarker characterization

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