Natural Products for Antithrombosis

Chen, Cen; Yang, Feng‐Qing; Zhang, Qian; Wang, Fengqin; Y, Hu; Xia, Zhining

doi:10.1155/2015/876426

Cited by 56 publications

(51 citation statements)

References 143 publications

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“…Andrographolide, a diterepene-lactone from Andrographis paniculata, is reported to delay thrombus formation by activating endothelial nitric oxide-nitric oxide eNOS-NO/cyclic GMP pathways, which result in the downregulation of the phospholipase/protein tyrosine kinase (PLC-γ2/PKC) and PI3K/Akt/p38 MAPK cascades [104]. The inhibition of PLC-γ2/PKC and PI3K/Akt/p38 MAPK cascades block platelet activation and aggregation by preventing cytoplasmic Ca 2+ mobilization necessary for the production of thromboxane A2, and inhibiting phosphorylation of PLA2 (phospholipase A 2) [108]. Wogonin from Scutellaria baicalensis, and the terpene-derivative borneol (found in a number of species, such as lavender, rosemary and Artemisia) also demonstrated anticoagulation activity.…”

Section: Antithrombotic Activitymentioning

confidence: 99%

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Sharifi‐Rad

Lankatillake

Dias

et al. 2020

JCM

190

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Among the major neurodegenerative disorders (NDDs), Alzheimer’s disease (AD) and Parkinson’s disease (PD), are a huge socioeconomic burden. Over many centuries, people have sought a cure for NDDs from the natural herbals. Many medicinal plants and their secondary metabolites are reported with the ability to alleviate the symptoms of NDDs. The major mechanisms identified, through which phytochemicals exert their neuroprotective effects and potential maintenance of neurological health in ageing, include antioxidant, anti-inflammatory, antithrombotic, antiapoptotic, acetylcholinesterase and monoamine oxidase inhibition and neurotrophic activities. This article reviews the mechanisms of action of some of the major herbal products with potential in the treatment of NDDs according to their molecular targets, as well as their regional sources (Asia, America and Africa). A number of studies demonstrated the beneficial properties of plant extracts or their bioactive compounds against NDDs. Herbal products may potentially offer new treatment options for patients with NDDs, which is a cheaper and culturally suitable alternative to conventional therapies for millions of people in the world with age-related NDDs.

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Section: Antithrombotic Activitymentioning

confidence: 99%

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Sharifi‐Rad

Lankatillake

Dias

et al. 2020

JCM

190

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“…Charcoal treatment is a major category of Chinese medicine, with 2000 years of historical application, especially in the treatment of haemorrhagic diseases that show a convergent haemostatic effect [1][2][3]. The haemostatic effect of charcoal has been included in the Chinese Pharmacopoeia [4].…”

Section: Introductionmentioning

confidence: 99%

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

et al. 2020

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High-temperature carbonisation is used to prepare many traditional Chinese medicine charcoal drugs, but the bioactive haemostatic substances of these medicines and their mechanisms are still unknown. This study developed and evaluated nanoparticles (NPs) derived from Selaginella pulvinate Carbonisata (STC) for the first time. The haemostatic effect of STC-NPs prepared at 300, 350, and 400 °C were investigated in mouse tail amputation and liver scratch experiments. STC-NPs obtained at 400 °C had the strongest haemostatic effect, and were accordingly characterised by ultraviolet–visible spectroscopy, fluorescence spectroscopy, Fourier transform infrared spectroscopy, transmission electron microscopy, high resolution transmission electron microscopy, X-ray diffractometry, and X-ray photoelectron spectroscopy. STC-NPs averaged 1.4–2.8 nm and exhibited a quantum yield of 6.06% at a maximum excitation wavelength of 332 nm and emission at 432 nm. STC-NPs displayed low toxicity against mouse monocyte macrophage RAW 264.7 cells by CCK-8 assay, and STC-NP treatment significantly shortened bleeding time in rat and mouse models. Coagulation assays showed that the haemostatic effects of STC-NPs were related to improving the fibrinogen and platelet contents, as well as decreasing the prothrombin time that resulted from stimulating extrinsic blood coagulation and activating the fibrinogen system. The STC-NPs had remarkable haemostatic effects in the tail amputation and liver scratch models; these effects may be associated with the exogenous coagulation pathway and activation of the brinogen system, according to the evaluation of the mouse coagulation parameters. This novel evaluation supports the material basis of STC use in traditional Chinese medicine, and this article is worthy of study by authors of clinical pharmacy.

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“…The abundant integrin binding sites in collagen fibrils are conductive for cell adhesion and migration (Sipila et al, 2018). However, collagen can bind vWF and blood coagulation proteins, which promotes platelet adhesion on the lumen surface of TEVG at the same time (Chen et al, 2015;Wu et al, 2002). Similar with collagen, elastin can promote EC proliferation, viability, and endothelialization of the lumen surface (Simionescu et al, 2006).…”

Section: Natural Polymersmentioning

confidence: 99%

Strategies in cell‐free tissue‐engineered vascular grafts

Yuan

Chen

Liu

et al. 2019

J Biomedical Materials Res

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Cardiovascular diseases (CVD) remain the leading cause of morbidity and mortality in the world, among which coronary artery diseases (CAD) are the most common type of CVD. Coronary artery bypass grafting (CABG) using autologous vein and artery grafts is the typical surgical intervention for CAD patients. However, for patients whose autologous grafts are not available, there are no appropriate substitutes for vascular grafts. Investigation of tissue-engineered vascular graft (TEVG) has persisted over decades with significant advancement, utilizing different types of biomaterials.In the past two decades, a great number of studies based on cell-seeding strategies were reported. However, limitations of cell-based strategies made clinical application difficult. With the understanding of stem cells and tissue remodeling process, strategies without cell-seeding emerged as potential methods to achieve in situ regeneration.A cell-free graft may recruit host cells and guide their participation in vascular remodeling. The grafts modified by bio-active molecules showed good results in promoting in situ regeneration and exhibited potential to make the vascular grafts off-the-shelf.In this review, the strategies for cell-free TEVG manufacturing were discussed, including the materials for fabricating TEVGs, the methods of functionalization to promote in situ regeneration, the challenges researchers faced in TEVG investigation, and finally the prospects in TEVG design.

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Natural Products for Antithrombosis

Cited by 56 publications

References 143 publications

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Impact of Natural Compounds on Neurodegenerative Disorders: From Preclinical to Pharmacotherapeutics

Haemostatic Nanoparticles-Derived Bioactivity of from Selaginella tamariscina Carbonisata

Strategies in cell‐free tissue‐engineered vascular grafts

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