Natural products for the treatment of neurodegenerative diseases

Cui, Donghan; Chen, Yajuan; Ye, Bengui; Guo, Wenhao; Wang, Dongdong; He, Jun

doi:10.1016/j.phymed.2023.155101

Cited by 12 publications

(3 citation statements)

References 137 publications

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“…Natural products, specifically those obtained from Traditional Chinese Medicines (TCMs), are the primary reservoirs of pharmaceuticals and have captivated researchers in their potential for treating ND [32]. Natural products have been shown to improve blood flow to the brain, stop neurodegeneration, make it easier for cerebral hematomas to dissolve, heal damaged nerve tissue, help memory recovery, and make nerve function better [33,34,35].…”

Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Trends and Prospects of Nano-delivered Phytopharmaceuticals for disease of Public health importance: A Review

Ajala,

Omoteso,

Ghazali

2024

STNANOMAT

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A significant amount of effective medicine can be found in phytochemicals thatare found in natural products or herb extracts. These natural drugs can be used in the treatment of public health diseases such as diabetes, cardiovascular disease, malaria, HIV, COVID-19, gastrointestinal disorders, neurodegenerative diseases, and cancer. There are significant therapeutic limitations when phytomedicines are administered in conventional pharmaceutical dosage forms like powders,tablets, solutions, brews, and balms. These include low aqueous solubility, poor permeability, degradation, and instability. As a result, there is low production yield, poor absorption and bioavailability, poor potency and efficacy, and toxicity in the body. As a result, phytomedicines are not as effective as they could be. Polymeric nanoparticles, lipid nanoparticles, liposomes, sterosomes, and metallic nanoparticles are novel drug delivery systems that circumvent the problems of conventional drug delivery systems. These nanocarriers can enhance phytomedicine's solubility, stability, and control, prolong the release of herbal medicine, and target specific sites within the body. As a result, herbal medicine can achieve maximum potency and efficacy with significantly fewer adverse effects. The use of phytopharmaceuticals as treatments for diseases that affect public health is extensively covered in this paper, as is the topic of nano-derived phytopharmaceuticals.

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Section: Neurodegenerative Diseasesmentioning

confidence: 99%

Trends and Prospects of Nano-delivered Phytopharmaceuticals for disease of Public health importance: A Review

Ajala,

Omoteso,

Ghazali

2024

STNANOMAT

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“…Recent studies have evidenced the beneficial effects of dietary supplementation with anti-inflammatory compounds on cognitive decline, neuroinflammation and oxidative stress by acting on the NF-kB pathway in AD-like animal models [107,108]. Curcumin, krill oil, chicoric acid, plasmalogens, lycopene, tryptophan-related dipeptides, hesperidin, and selenium peptides have been tested, despite their heterogeneity, and have shown helpful actions on cognitive deficits and LPS-induced neuroinflammatory responses in rodents by affecting the NF-κB pathway [106][107][108]. Overall, dietary interventions could represent positive factors in countering AD, or other ND, by acting on neuroprotection and immune regulation.…”

Section: Transcriptional Factors and Related Pathways: Focus On Nf-kb...mentioning

confidence: 99%

“…For example, ostholeloaded nanoemulsion has been reported to effectively target the brain and have beneficial effects in the treatment of AD. Therefore, the development of potential nanocarriers such as liposomes, microspheres, and nanoemulsions could improve the bioavailability of such compounds [107,108]. However, further studies are needed to evaluate the real therapeutic effect of such compounds on neuroinflammation.…”

Section: Transcriptional Factors and Related Pathways: Focus On Nf-kb...mentioning

confidence: 99%

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Balistreri,

Monastero

2023

Brain Sciences

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The term “neuroinflammation” defines the typical inflammatory response of the brain closely related to the onset of many neurodegenerative diseases (NDs). Neuroinflammation is well known, but its mechanisms and pathways are not entirely comprehended. Some progresses have been achieved through many efforts and research. Consequently, new cellular and molecular mechanisms, diverse and conventional, are emerging. In listing some of those that will be the subject of our description and discussion, essential are the important roles of peripheral and infiltrated monocytes and clonotypic cells, alterations in the gut–brain axis, dysregulation of the apelinergic system, alterations in the endothelial glycocalyx of the endothelial component of neuronal vascular units, variations in expression of some genes and levels of the encoding molecules by the action of microRNAs (miRNAs), or other epigenetic factors and distinctive transcriptional factors, as well as the role of autophagy, ferroptosis, sex differences, and modifications in the circadian cycle. Such mechanisms can add significantly to understanding the complex etiological puzzle of neuroinflammation and ND. In addition, they could represent biomarkers and targets of ND, which is increasing in the elderly.

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Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT_2A and D₂ receptor interaction pathways

Islam,

Chowdhury,

Bhuia

et al. 2024

Drug Development Research

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Schizophrenia affects identification and disturbs our thinking and motivational capacity. Long‐term use of daidzin (DZN) is evident to enhance attention and memory in experimental animals. This study aimed to investigate the effect of DZN on Swiss mice. To check animals' attention, identification, thinking, and motivational ability, we performed behavioral studies using marble burying, dust removal, and trained swimming protocols. For this, a total of 36 male Swiss albino mice were randomly divided into six groups, consisting of 6 animals in each group, as follows: control (vehicle), DZN‐1.25, DZN‐2.5, DZN‐5 mg/kg, olanzapine (OLN)‐2, and a combination of DZN‐1.25 with OLN‐2. Additionally, in silico studies are also performed to understand the possible molecular mechanisms behind this neurological effect. Findings suggest that DZN dose‐dependently and significantly (p < .05) increased marble burying and removed dust while reducing the time to reach the target point. DZN‐1.25 was found to enhance OLN's effect significantly (p < .05), possibly via agonizing its activity in animals. In silico findings suggest that DZN has strong binding affinities of ‐10.1 and ‐10.4 kcal/mol against human serotonin 2 A (5‐HT2A) and dopamine 2 (D2) receptors, respectively. Additionally, DZN exhibits favorable pharmacokinetic and toxicity properties. We suppose that DZN may exert its attention‐ and memory‐enhancing abilities by interacting with 5‐HT2A and D2 receptors. It may exert a synergistic antischizophrenia‐like effect with the standard drug, OLN. Further studies are required to discover the exact molecular mechanism for this neurological function in animals.

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Natural products for the treatment of neurodegenerative diseases

Cited by 12 publications

References 137 publications

Trends and Prospects of Nano-delivered Phytopharmaceuticals for disease of Public health importance: A Review

Trends and Prospects of Nano-delivered Phytopharmaceuticals for disease of Public health importance: A Review

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT_2A and D₂ receptor interaction pathways

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Natural products for the treatment of neurodegenerative diseases

Cited by 12 publications

References 137 publications

Trends and Prospects of Nano-delivered Phytopharmaceuticals for disease of Public health importance: A Review

Trends and Prospects of Nano-delivered Phytopharmaceuticals for disease of Public health importance: A Review

Neuroinflammation and Neurodegenerative Diseases: How Much Do We Still Not Know?

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT2A and D2 receptor interaction pathways

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Product

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About

Daidzin enhances memory and the antischizophrenia drug olanzapine's effects, possibly through the 5‐HT_2A and D₂ receptor interaction pathways