Natural Products from Corals

Li, Guoqiang; Li, Pinglin; Tang, Xiangming

doi:10.1007/978-94-024-1612-1_16

Cited by 9 publications

(12 citation statements)

References 157 publications

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“…Seven new diterpenoids, flexibilisolides C-G, flexibilisin C, and 11,12-secoflexibillin along with seven known compounds, were derived from the soft coral Sinularia flexibilis [103]. Flexibilisolide C (201), 11-dehydrosinulariolide (197), 14-deoxycrassin (44), 11-episinulariolide acetate (202), and 3,4:8,11-bisepoxy-7-acetoxycembra-15(17)-en-1,12olide (203) showed cytotoxicity toward human cervical epithelioid carcinoma (HeLa) with ED 50 values ranging from 11.6 to 15.6 µg/mL. Moreover, flexibilisolide C (201), 11dehydrosinulariolide (197), 14-deoxycrassin (44), and 11-episinulariolide acetate (202) were found to exhibit cytotoxicity against B-16 (human melanin carcinoma) cell line with ED 50 values comparable to that of the positive control 5-fluorouracil (9.9 ± 0.8 µg/mL).…”

Section: Cytotoxic Compounds From the Genus Sinulariamentioning

confidence: 99%

Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years

et al. 2022

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The octocoral family Alcyoniidae represents a rich source of bioactive substances with intriguing and unique structural features. This review aims to provide an updated overview of the compounds isolated from Alcyoniidae and displaying potential cytotoxic activity. In order to allow a better comparison among the bioactive compounds, we focused on molecules evaluated in vitro by using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide (MTT) assay, by far the most widely used method to analyze cell proliferation and viability. Specifically, we surveyed the last thirty years of research, finding 153 papers reporting on 344 compounds with proven cytotoxicity. The data were organized in tables to provide a ranking of the most active compounds, to be exploited for the selection of the most promising candidates for further screening and pre-clinical evaluation as anti-cancer agents. Specifically, we found that (22S,24S)-24-methyl-22,25-epoxyfurost-5-ene-3β,20β-diol (16), 3β,11-dihydroxy-24-methylene-9,11-secocholestan-5-en-9-one (23), (24S)-ergostane-3β,5α,6β,25 tetraol (146), sinulerectadione (227), sinulerectol C (229), and cladieunicellin I (277) exhibited stronger cytotoxicity than their respective positive control and that their mechanism of action has not yet been further investigated.

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Section: Cytotoxic Compounds From the Genus Sinulariamentioning

confidence: 99%

Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years

et al. 2022

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“…Compound (2) exhibited moderate cytotoxicity against acute leukemia (HL-60) cell line with IC50 value of 33.5 µM and a weak effect on the hepatoma cancer (HepG2) and colon adenocarcinoma (SW480) cell lines with IC50 values of 64.3 and 71.0 µM, respectively [50]. The structures of the steroids (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18) are shown in Figure 1 and the potential biological activities are shown in Table 1. Steroids, 8αH-3β,11-dihydroxy-5α,6α-expoxy-24-methylene-9,11-secocholestan-9-one (4) and crassarosteroside A (5) were obtained from Sinularia granosa and S. crassa soft coral extracts [51,52], respectively.…”

Section: Steroids Derived From the Genus Sinulariamentioning

confidence: 99%

“…In addition, photosynthetic corals are successfully cultivated in artificial conditions and are the subject of chemical and biomedical investigation [3,4]. Soft corals produce more than 5800 secondary metabolites [5], including rare and unusual fatty acids [6][7][8][9][10][11][12][13], terpenoids [14][15][16], quinones [17], alkaloids [18][19][20][21][22][23], glycosides [24][25][26][27][28][29][30][31] and steroids [18,[32][33][34][35][36][37]. It is known that many secondary metabolites isolated from marine invertebrates including soft corals, exhibit anticancer and other pharmacological activities [38][39][40][41][42][43][44][45].…”

Section: Introductionmentioning

confidence: 99%

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

et al. 2020

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The review is devoted to the chemical diversity of steroids produced by soft corals and their determined and potential activities. There are about 200 steroids that belong to different types of steroids such as secosteroids, spirosteroids, epoxy- and peroxy-steroids, steroid glycosides, halogenated steroids, polyoxygenated steroids and steroids containing sulfur or nitrogen heteroatoms. Of greatest interest is the pharmacological activity of these steroids. More than 40 steroids exhibit antitumor and related activity with a confidence level of over 90 percent. A group of 32 steroids shows anti-hypercholesterolemic activity with over 90 percent confidence. Ten steroids exhibit anti-inflammatory activity and 20 steroids can be classified as respiratory analeptic drugs. Several steroids exhibit rather rare and very specific activities. Steroids exhibit anti-osteoporotic properties and can be used to treat osteoporosis, as well as have strong anti-eczemic and anti-psoriatic properties and antispasmodic properties. Thus, this review is probably the first and exclusive to present the known as well as the potential pharmacological activities of 200 marine steroids.

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“…Moreover, MNPs play an important ecological role amongst marine organisms, especially invertebrates, which compete intensely for nutrients, light, and space [ 13 ]. In this context, invertebrates, such as the soft coral Xenia sp., are recognized as a source of secondary marine natural products such as terpenoids, including diterpenes and sesquiterpenes, capnellenes, and steroids [ 14 ]. The diversity of marine-derived sterols was predicted by Bergmann in 1962, who extensively reviewed sterols’ structures and distribution [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Antiproliferative Isoprenoid Derivatives from the Red Sea Alcyonacean Xenia umbellata

et al. 2021

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From the soft coral Xenia umbellata, seven isoprenoid derivatives were isolated, including a new xenicane diterpene, xeniolide O (5) and a new gorgostane derivative gorgst-3β,5α,6β,11α,20(S)-pentol-3-monoacetate (7), along with three known sesquiterpenes (1–3), a known diterpene (4), and a known steroid (6). The extensive analyses of the NMR, IR, and MS spectral data led to determination of their chemical structures. Compounds 1–7 displayed a cytotoxic effect against breast adenocarcinoma (MCF-7), hepatocellular carcinoma (HepG2), and cervix adenocarcinoma (HeLa), with IC50 values ranging between 1.5 ± 0.1–23.2 ± 1.5; 1.8 ± 0.1–30.6 ± 1.1 and 0.9 ± 0.05–12.8 ± 0.5 μg/mL, respectively. Compound 3 showed potent cytotoxic effects against MCF-7, HepG2, and HeLa with IC50 values = 2.4 ± 0.20, 3.1 ± 0.10 and 0.9 ± 0.05 μg/mL, respectively. Compounds 2, 5, and 7 displayed cytotoxic effect against Hela cells with IC50 values = 12.8 ± 0.50, 6.7 ± 1.00 and 11.5 ± 2.20 μg/mL, respectively. Two DNA binding dyes, acridine orange (AO) and ethidium bromide (EtBr) were used for the detection of viable, apoptotic, and necrotic cells. The early apoptotic cell death was observed in all types of treated cells. The late apoptotic cells were highly present in HepG2 cells. Compounds 5 and 7 induced a high percentage of necrosis towards HepG2 and HeLa cells. The late apoptosis was recorded as a high rate after treatment with 7 on all cancer cells.

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Natural Products from Corals

Cited by 9 publications

References 157 publications

Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years

Cytotoxic Compounds from Alcyoniidae: An Overview of the Last 30 Years

Chemical Diversity of Soft Coral Steroids and Their Pharmacological Activities

Antiproliferative Isoprenoid Derivatives from the Red Sea Alcyonacean Xenia umbellata

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