Natural products from marine invertebrates against Leishmania parasites: a comprehensive review

Oliveira, M. Beatriz P.P.; Barreira, Luísa; Gangadhar, Katkam N.; Rodrigues, Maria João; Santos, Tamára; Varela, João; Custódio, Luísa

doi:10.1007/s11101-016-9455-3

Cited by 13 publications

(8 citation statements)

References 72 publications

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“…Considered as neglected tropical diseases, leishmaniasis and Chagas disease affects millions of people worldwide, however, first line existing treatments are not satisfactory mainly due to drug resistance, lack of effectiveness and toxicity [3,5].…”

Section: Discussionmentioning

confidence: 99%

“…Marine natural products have provided the pharmaceutical industry with many potent compounds [2]. However, despite numerous marine molecules that have been tested to date in vitro for their trypanocidal and leishmanicidal activity, mainly obtained from sponges and corals [3,4,5], none has reached the market for the treatment of NTDs caused by kinetopastid parasites.…”

Section: Introductionmentioning

confidence: 99%

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Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

et al. 2019

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Bioassay-guided fractionation of the antikinetoplastid extract of the brown alga Dictyota spiralis has led to the isolation of spiralyde A (1), a new dolabellane aldehyde, along with other five known related diterpenes (2–6). Their structures were determined by HRESIMS, 1D and 2D NMR spectroscopy, and comparison with data reported in the literature. The antiparasitic activity of all compounds was evaluated. Spiralyde A (1) and the known compound 3,4-epoxy-7,18-dolabelladiene (2) were the most active compounds against Leishmania amazonensis and Trypanosoma cruzi. Spiralyde A (1) was the most potent compound, comparable to benznidazole, the reference drug for trypanocidal activity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

et al. 2019

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“…In addition, other sources should also be examined to look for novel, effective leishmanicidal agents. For instance, marine organisms have been considered as promising suppliers of compounds with novel structures and noteworthy antiparasitic activity [40][41][42], including antileishmanial properties [43][44][45]. In this sense, it may be worthwhile considering marine specimens in future studies, especially marine microorganisms, whose chemical composition and biological activity-to our knowledge-remain to be deeply explored.…”

Section: General Findingsmentioning

confidence: 99%

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

2020

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Leishmaniasis is a parasitic morbid/fatal disease caused by Leishmania protozoa. Twelve million people worldwide are appraised to be currently infected, including ca. two million infections each year, and 350 million people in 88 countries are at risk of becoming infected. In Colombia, cutaneous leishmaniasis (CL) is a public health problem in some tropical areas. Therapeutics is based on traditional antileishmanial drugs, but this practice has several drawbacks for patients. Thus, the search for new antileishmanial agents is a serious need, but the lack of adequately funded research programs on drug discovery has hampered its progress. Some Colombian researchers have conducted different research projects focused on the assessment of the antileishmanial activity of naturally occurring and synthetic compounds against promastigotes and/or amastigotes. Results of such studies have separately demonstrated important hits and reasonable potential, but a holistic view of them is lacking. Hence, we present the outcome from a systematic review of the literature (under PRISMA guidelines) on those Colombian studies investigating antileishmanials during the last thirty-two years. In order to combine the general efforts aiming at finding a lead against Leishmania panamensis (one of the most studied and incident parasites in Colombia causing CL) and to recognize structural features of representative compounds, fingerprint-based analyses using conventional machine learning algorithms and clustering methods are shown. Abstraction from such a meta-description led to describe some function-determining molecular features and simplify the clustering of plausible isofunctional hits. This systematic review indicated that the Colombian efforts for the antileishmanials discovery are increasingly intensified, though improvements in the followed pathways must be definitively pursued. In this context, a brief discussion about scope, strengths and limitations of such advances and relationships is addressed.

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“…The mound is built by burrowing the muddy soil using their appendages to seek food and their behaviour in destroying the apical plant shoots has classify this mud lobster as pest [1]. The crustaceans of mud lobster are included in marine organisms that have great potential in natural antibacterial sources [2,3]. Astaxanthin in crustacean is widely investigated and used in several applications such as in pharmaceuticals, chemicals, food and animal feed [4].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial potential of methanolic and hexanic extracts of mud lobster (Thalassina anomala) from Bintulu, Sarawak, Malaysia

Zohir

Aziz

Rajaee

et al. 2018

RIB

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Present study demonstrated the antibacterial potential of three different body parts, abdomen, carapace and cheliped of mud lobster (Thalassina anomala) which were extracted with methanol and hexane. Three test bacteria were used in this study namely Bacillus cereus, Escherichia coli, and Salmonella enterica. Present study found that in general, methanolic and hexane extracts of different body parts had variable inhibitory responses on different test bacteria with methanolic extract had greater inhibitory response than hexane extract. In methanol extraction, B. cereus significantly had greatest negative impact (p<0.05) on growth after treated with cheliped (21 mm zone of inhibition) extract of mud lobster as compared to carapace (9.2 mm) and abdominal (8.8 mm) extracts of mud lobster. Overall, the growth of S. enterica was much affected with the presence of all methanolic body-part extracts of mud lobster. In hexane extraction, B. cereus growth was not affected with all body-part extracts of mud lobster. However, E. coli and S. enterica were affected with no significantly different (p>0.05) among body-part extracts and between them. Present study concludes that the extracts of mud lobster of all body-part in methanol possess greater inhibitory effect on bacterial growth than extracts in hexane thus the methanolic extract of mud lobster has the potential to be exploited as a natural source of antibacterial agent.

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Natural products from marine invertebrates against Leishmania parasites: a comprehensive review

Cited by 13 publications

References 72 publications

Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

Spiralyde A, an Antikinetoplastid Dolabellane from the Brown Alga Dictyota spiralis

Colombian Contributions Fighting Leishmaniasis: A Systematic Review on Antileishmanials Combined with Chemoinformatics Analysis

Antibacterial potential of methanolic and hexanic extracts of mud lobster (Thalassina anomala) from Bintulu, Sarawak, Malaysia

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