Natural Products from Plants and Fungi as Fungicides

Sokóvić, Marina; Glamočlija, Jasmina; Ćirić, Ana

doi:10.5772/50277

Cited by 15 publications

(4 citation statements)

References 140 publications

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“…Findings of Unekwu et al (2014) had reported most of these phytochemicals as functional ingredients in a number of medicinal mushrooms. These phytochemicals are known to function as antibacterial, antifungal, antioxidants and anticancer agents (Cowan 1999; Sokovic et al 2013). Thus, phytochemicals in medicinal mushrooms had tremendous potentials on the health care system by preventing several degenerative diseases and physiological disorders.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes

Ogidi

Oyetayo

2016

Mycology

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The phytochemical property and inhibitory potential of petroleum ether and ethanol extracts of Lenzites quercina, Ganoderma lucidum and Rigidoporus ulmarius were assessed. Standard method was adopted to quantify the phytochemicals in the mushroom extracts. Poisoned food technique was used to assess the inhibition of the extracts obtained from the macrofungi against some pathogenic dermatophytes. The phenolic content of the studied mushroom extracts ranged from 15.7 to 83.8 mg gallic acid equivalent (GAE)/g extract. Ethanolic extract of G. lucidum has the higher content of alkaloids (34.3 mg/g) and flavonoids (18.1 mg/g). Exactly 33.1 mg/g of terpenoids and 16.6 mg/g of saponins were also quantified in ethanolic extract of L. quercina. Extracts of L. quercina, G. lucidum and R. ulmarius exhibited wide range of mycelia inhibition at 50 mg/ml on the tested dermatophytes. The consistent inhibition displayed by the mushroom extracts against the dermatophytes affirms that these wild mushrooms contain bioactive compounds that are antifungal in nature and may possess the ability to cure dermatophyte infections.

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Section: Discussionmentioning

confidence: 99%

Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes

Ogidi

Oyetayo

2016

Mycology

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“…In Asia, the continent with the largest number of publications on the subject, the use of traditional, popular medicine continues to grow (De Boer and Cotingting, 2014) due to the low costs, easy access, the frequent reduced side effects and toxicity, and their better biodegradable properties (Soković et al, 2013). This is often reinforced by difficulties in accessing health services and obtaining essential medicines (WHO, 2007(WHO, -2017Ozawa et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

et al. 2021

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Background: It is estimated that one in five people worldwide faces a diagnosis of a malignant neoplasm during their lifetime. Carvacrol and its isomer, thymol, are natural compounds that act against several diseases, including cancer. Thus, this systematic review aimed to examine and synthesize the knowledge on the antitumor effects of carvacrol and thymol.Methods: A systematic literature search was carried out in the PubMed, Web of Science, Scopus and Lilacs databases in April 2020 (updated in March 2021) based on the PRISMA 2020 guidelines. The following combination of health descriptors, MeSH terms and their synonyms were used: carvacrol, thymol, antitumor, antineoplastic, anticancer, cytotoxicity, apoptosis, cell proliferation, in vitro and in vivo. To assess the risk of bias in in vivo studies, the SYRCLE Risk of Bias tool was used, and for in vitro studies, a modified version was used.Results: A total of 1,170 records were identified, with 77 meeting the established criteria. The studies were published between 2003 and 2021, with 69 being in vitro and 10 in vivo. Forty-three used carvacrol, 19 thymol, and 15 studies tested both monoterpenes. It was attested that carvacrol and thymol induced apoptosis, cytotoxicity, cell cycle arrest, antimetastatic activity, and also displayed different antiproliferative effects and inhibition of signaling pathways (MAPKs and PI3K/AKT/mTOR).Conclusions: Carvacrol and thymol exhibited antitumor and antiproliferative activity through several signaling pathways. In vitro, carvacrol appears to be more potent than thymol. However, further in vivo studies with robust methodology are required to define a standard and safe dose, determine their toxic or side effects, and clarify its exact mechanisms of action.This systematic review was registered in the PROSPERO database (CRD42020176736) and the protocol is available at https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=176736.

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“…Of the current few fungus-based products authorized by the EU as fungicides, none are metabolites. Therefore, the antifungal properties of many fungal species, especially endophytes, present great potential for use as biological fungicides [ 137 ], although so far they remain a research curiosity rather than a trait of commercial significance, at least with regard to agricultural purposes, as indicated by Card et al [ 138 ] in their review on the antagonism toward plant pathogens by Epichloë endophytes.…”

Section: Current and Future Perspectives For A Large-scale Applicationmentioning

confidence: 99%

Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives

Rodrigo

García-Latorre

Santamaría

2021

Plants

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Many fungi, especially endophytes, have been found to produce multiple benefits in their plant hosts, with many of these benefits associated with the protection of plants against fungal diseases. This fact could be used in the development of new bio-products that could gradually reduce the need for chemical fungicides, which have been associated with multiple health and environmental problems. However, the utilization of the living organism may present several issues, such as an inconsistency in the results obtained and more complicated management and application, as fungal species are highly influenced by environmental conditions, the type of relationship with the plant host and interaction with other microorganisms. These issues could be addressed by using the bioactive compounds produced by the fungus, in cases where they were responsible for positive effects, instead of the living organism. Multiple bioactive compounds produced by fungal species, especially endophytes, with antifungal properties have been previously reported in the literature. However, despite the large amount of these metabolites and their potential, extensive in-field application on a large scale has not yet been implemented. In the present review, the main aspects explaining this limited implementation are analyzed, and the present and future perspectives for its development are discussed.

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Natural Products from Plants and Fungi as Fungicides

Cited by 15 publications

References 140 publications

Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes

Phytochemical property and assessment of antidermatophytic activity of some selected wild macrofungi against pathogenic dermatophytes

Antitumor Effects of Carvacrol and Thymol: A Systematic Review

Metabolites Produced by Fungi against Fungal Phytopathogens: Review, Implementation and Perspectives

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