Natural products from polar organisms: Structural diversity, bioactivities and potential pharmaceutical applications

Tripathi, Vikash Chandra; Satish, S; Horam, Soyar; Raj, Sneha; lal, Agney; Arockiaraj, Jesu; Pasupuleti, Mukesh; Dikshit, Dinesh K.

doi:10.1016/j.polar.2018.04.006

Cited by 41 publications

(23 citation statements)

References 132 publications

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“…Polar microorganisms could represent an answer to the rising needs of novel and effective bioactive compounds for contrasting human diseases, and protecting human health and the environment [108]. In the coming decades, chemists and biologists will be required to closely collaborate with each other by cross-disciplinary interactions to provide innovative approaches and promising candidates within Polar bioprospecting activities.…”

Section: Discussionmentioning

confidence: 99%

“…In the coming decades, chemists and biologists will be required to closely collaborate with each other by cross-disciplinary interactions to provide innovative approaches and promising candidates within Polar bioprospecting activities. In addition to the screening and characterization of compounds, a further effort should also be made to address mechanisms driving their activities [108]. Finally, as it is well known, bioprospecting is regulated by various international law regimes worldwide.…”

Section: Discussionmentioning

confidence: 99%

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Bacteria Associated with Marine Benthic Invertebrates from Polar Environments: Unexplored Frontiers for Biodiscovery?

Giudice

Rizzo

2018

Diversity

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The ecological function of bacteria-invertebrate interactions in Polar areas remains poorly understood, despite increasing evidence that microbial metabolites may play pivotal roles in host-associated chemical defense and in shaping the symbiotic community structure. The metabolic and physiological changes that these organisms undergo in response to adapting to extreme conditions result in the production of structurally and functionally novel biologically active molecules. Deepening our knowledge on the interactions between bacteria and their invertebrate host would be highly helpful in providing the rationale for why (e.g., competition or cooperative purpose) and which (whether secondary metabolites, enzymes, or proteins) bioactive compounds are produced. To date, cold-adapted bacteria associated with marine invertebrates from the Arctic and Antarctica have not been given the attention they deserve and the versatility of their natural products remains virtually unexplored, even if they could represent a new attractive frontier in the search for novel natural compounds. This review is aimed at showcasing the diversity of cold-adapted bacteria associated with benthic invertebrates from Polar marine areas, highlighting the yet unexplored treasure they represent for biodiscovery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bacteria Associated with Marine Benthic Invertebrates from Polar Environments: Unexplored Frontiers for Biodiscovery?

Giudice

Rizzo

2018

Diversity

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“…In order to survive in the cold, extreme and inhospitable environment conditions, polar organisms produce an array of unique metabolites which confer an advantage and offers protection from predation. Out of all the natural products reported from polar organisms, 38% of them showed bioactivity of pharmaceutical relevance" [5]. This illustrates the tremendous potential of the polar organisms as a source of new therapeutic agents for infectious and lifestyle associated diseases.…”

Section: Introductionmentioning

confidence: 98%

“…Adaptation to extreme Arctic climatic conditions can be increased by changing a diet and implementing functional food products based on the Arctic bioresources (plant and animal raw materials). They have a huge value in pharmaceuticals industry as "molecules or templates for discovery or further development of new drugs" [5]. Recent genetic based studies showed that "the diversity of the polar region is much more than previously predicted.…”

Section: Introductionmentioning

confidence: 99%

The Export Potential of Innovative Bioresources of the Arctic in the Economic Zone of the Polar Silk Road

Bogdanova¹,

Lobanov²,

Andronov³

et al. 2020

Proceedings of the “New Silk Road: Business Cooperation and Prospective of Economic Development” (NSRBCPED 2019)

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Due to active exploration of the Arctic, employing shift workers from the southern regions, development of the Northern sea route and the Arctic shelf, there is a high need to increase resistance to cold, especially in extreme stress situations, maintain high efficiency and prevent diseases in the harsh conditions of the Arctic. The use of the Arctic plant and animal raw materials to produce innovative functional food products helps to improve human adaptation in cold environment with long polar days and nights, frequent geomagnetic changes affecting the psychological state of a person and his health to perform professional duties. China is interested in the cooperation in the field of biomedicine, because of the priorities mentioned in the Arctic strategy, aimed at its involving into the projects of the Arctic exploration. The paper highlights the perspectives of the export potential of innovative products, produced from the Arctic bioresources in the economic zone of the Polar silk road. Based on the data collected by the research team during scientific expeditions and laboratory biological and chemical studies of the Arctic plants (Shiksha black, brown Sphagnum, Cetraria, dwarf birch leaf, Siberian larch needles etc.) and local fish and meat in the Arctic zone of Western Siberia in 2014-19, minimum sufficient norms of consuming Arctic traditional food products and the samples of innovative functional products were developed: "Heart of the North", sets of fast cooking hot food "Teplorod" and "Operator", Bread "Port Sabetta", drink "Yamal IRI", chocolate "Yamal lichen" and chewing marmalade "Yamal herbarium". The reported study was funded by RFBR, project number 18-010-00875. This is an open access article distributed under the CC BY-NC 4.0 license -http://creativecommons.org/licenses/by-nc/4.0/. 414 contribution to projects related to oil and gas and energy complexes, international scientific strategic planning, as well as transit commercial shipping is increasing. As a result, the share of highly qualified personnel attracted to perform work in the economic zone of the Polar Silk Road, is growing.

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“…Many articles have been published describing the features of the mechanisms of biological action of previously discovered compounds. Of particular interest are compounds isolated from holothurians and sea urchins [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Features and Advantages of Supercritical CO2 Extraction of Sea Cucumber Cucumaria frondosa japonica Semper, 1868

et al. 2020

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Extraction process of Cucumaria frondosa japonica Semper, 1868, which are subspecies of Cucumaria frondosa (Gunnerus, 1767), were studied. It was shown that supercritical carbon dioxide extraction of holothuria was more effective than conventional solvent extraction. Step-by-step extraction with carbon dioxide followed by supercritical extraction with the addition of a co-solvent of ethanol can almost double the yields of extracts of triterpene glycosides, styrenes and carotenoids. Moreover, the fraction of triterpene glycosides practically does not contain colored impurities, in contrast to traditional ethanol extraction. The obtained extracts by HPLC in combination with tandem mass spectrometry (HPLC-MS/MS) identified 15 triterpene glycosides, 18 styrene compounds and 14 carotenoids. Supercritical extraction made it possible to obtain extracts with yields superior to conventional hexane and alcohol extracts. Moreover, such an approach with the use of supercritical fluid extraction (SFE) and subsequent profiling of metabolites can help with the study of holothuria species that are not as well studied.

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Natural products from polar organisms: Structural diversity, bioactivities and potential pharmaceutical applications

Cited by 41 publications

References 132 publications

Bacteria Associated with Marine Benthic Invertebrates from Polar Environments: Unexplored Frontiers for Biodiscovery?

Bacteria Associated with Marine Benthic Invertebrates from Polar Environments: Unexplored Frontiers for Biodiscovery?

The Export Potential of Innovative Bioresources of the Arctic in the Economic Zone of the Polar Silk Road

Features and Advantages of Supercritical CO2 Extraction of Sea Cucumber Cucumaria frondosa japonica Semper, 1868

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