Natural Products in Drug Discovery: Approaches and Development

Tresina, P. S.; Selvam, Murugeswaran Santhiya; Rajesh, A; Doss, A.; Mohan, V. R.

doi:10.9734/jpri/2021/v33i35a31879

Cited by 10 publications

(4 citation statements)

References 74 publications

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“…The test was performed as outlined by Rajesh et al, (2019). 1 ml of 20 mM Tris-HCl buffer (pH 7.4), 0.06 mg of trypsin, and 1 ml of the test sample with varying concentrations (100-500 g/ml) were all included in the reaction mixture (2 ml).…”

Section: Antiproteinase Activitymentioning

confidence: 99%

Assessment of the Nutraceutical Values of the Leaf of Tapinanthus Globiferus Hosted by the Neem Tree

Oloruntola

2023

Livestock Studies

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The objective of this study is to evaluate the nutraceutical values of the leaf of Tapinanthus globiferus hosted by the neem tree. The phytochemical composition, antioxidant activities, antidiabetic properties, anti-inflammatory capabilities, and proximate composition of the Tapinanthus globiferus leaf powder (TLP) were examined. The results revealed the phytochemical profiles: phenol (501.51 mg/g), alkaloids (408.25 mg/g), saponins (7.16 mg/g), steroids (7.16 mg/g), flavonoids 933.79 mg/g) and tannins (86.53 mg/g); antioxidant assay results: Ferrous chelating activity (51.17%), hydroxyl radical inhibition (55.96%), ABTS (76.09%), DPPH (71.34%) and lipid oxidation inhibition (66.18%); antidiabetic assay results: the α-glucosidase inhibition (75.88%) and α-amylase inhibition (72.14 %); anti-inflammatory assays: antiproteinase activity (72.38%) and albumin denaturation inhibition (44.67%) of TLP. Tapinanthus globiferus leaf powder has nitrogen-free extract content of 36.09%, 18.47% crude protein, 13.27% moisture, 12.78% ash, 9.44% crude fibre, and 9.93% crude fat. These findings indicated that TLP had anti-inflammatory, anti-diabetic, and antioxidant properties.

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Section: Antiproteinase Activitymentioning

confidence: 99%

Assessment of the Nutraceutical Values of the Leaf of Tapinanthus Globiferus Hosted by the Neem Tree

Oloruntola

2023

Livestock Studies

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“…Most biologically active natural product compounds are secondary metabolites with very complex structures. Natural products differ significantly from synthetic drugs in three important aspects, (a) in the ratio of aromatic ring atoms to total heavy atoms (lower in natural products), (b) in a number of solvated hydrogen-bond donors and acceptors (higher in natural products) and(c) natural product possess greater molecular rigidity 36 .…”

Section: Chemical Diversity Of Natural Productsmentioning

confidence: 99%

Untitled

2022

IJPSR

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Traditional Chinese Medicine (TCM) have been extensively documented over the past thousands of years 1 . The written records of Ayurveda, the Indian medicinal system, originated before the 1 st millennium BC 2 . However, logical drug discovery from plants commenced at the beginning of the 19 th century, when Friedrich Serturner successfully extracted an analgesic and sleep-inducing agent from the Opium poppy, themorphium (morphine) that, was named after Morpheus, the Greek god of dreams. He thoroughly discussed isolation, crystallization,

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“…Natural Products have been used since ancient times in drug development. Between 1981 and 2019, 36.3% of the small molecules were developed for the treatment of antimicrobial, antiparasitic, and anticancer conditions based on natural products or their derivatives [9][10][11]. Less than 20% of it is sourced from plants, as stated in reference [12].…”

Section: Introductionmentioning

confidence: 99%

Selection of Mexican Medicinal Plants by Identification of Potential Phytochemicals with Anti-Aging, Anti-Inflammatory, and Anti-Oxidant Properties through Network Analysis and Chemoinformatic Screening

Barrera-Vázquez,

Montenegro-Herrera,

Martínez-Enríquez

et al. 2023

Biomolecules

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Many natural products have been acquired from plants for their helpful properties. Medicinal plants are used for treating a variety of pathologies or symptoms. The axes of many pathological processes are inflammation, oxidative stress, and senescence. This work is focused on identifying Mexican medicinal plants with potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects through network analysis and chemoinformatic screening of their phytochemicals. We used computational methods to analyze drug-like phytochemicals in Mexican medicinal plants, multi-target compounds, and signaling pathways related to anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence mechanisms. A total of 1373 phytochemicals are found in 1025 Mexican medicinal plants, and 148 compounds showed no harmful functionalities. These compounds displayed comparable structures with reference molecules. Based on their capacity to interact with pharmacological targets, three clusters of Mexican medicinal plants have been established. Curatella americana, Ximenia americana, Malvastrum coromandelianum, and Manilkara zapota all have anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects. Plumeria rubra, Lonchocarpus yucatanensis, and Salvia polystachya contained phytochemicals with anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence reported activity. Lonchocarpus guatemalensis, Vallesia glabra, Erythrina oaxacana, and Erythrina sousae have drug-like phytochemicals with potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects. Between the drug-like phytochemicals, lonchocarpin, vallesine, and erysotrine exhibit potential anti-oxidant, anti-inflammatory, anti-aging, and anti-senescence effects. For the first time, we conducted an initial virtual screening of selected Mexican medicinal plants, which was subsequently confirmed in vivo, evaluating the anti-inflammatory activity of Lonchocarpus guatemalensis Benth in mice.

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Natural Products in Drug Discovery: Approaches and Development

Cited by 10 publications

References 74 publications

Assessment of the Nutraceutical Values of the Leaf of Tapinanthus Globiferus Hosted by the Neem Tree

Assessment of the Nutraceutical Values of the Leaf of Tapinanthus Globiferus Hosted by the Neem Tree

Untitled

Selection of Mexican Medicinal Plants by Identification of Potential Phytochemicals with Anti-Aging, Anti-Inflammatory, and Anti-Oxidant Properties through Network Analysis and Chemoinformatic Screening

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