Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

Sirasanagandla, Srinivasa Rao; Al-Huseini, Isehaq; Sakr, Hussein F.; Moqadass, Marzie; Das, Srijit; Juliana, Norsham; Abu, Izuddin Fahmy

doi:10.3390/molecules27175384

Cited by 26 publications

(25 citation statements)

References 337 publications

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“…Evidence has pointed out that polybrominated diphenyl ethers are more likely to disrupt the differentiated NPCs in an hESC neural differentiation model and exert their cytotoxicity relying on the developmental stage 285 . Bisphenols are widely used to produce epoxy resins, and polycarbonate plastics, which have been shown to have endocrine disruptor effects and developmental toxicity in mammalian embryos 286,287 . Recently, the retinotoxicity of BPA, TBBPA, and TBBPS has been evaluated with human retinal organoids derived from ESCs 288 .…”

Section: Biomedical Applications Of Organoidsmentioning

confidence: 99%

Organoids: The current status and biomedical applications

Yang

Kung

et al. 2023

MedComm

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Organoids are three‐dimensional (3D) miniaturized versions of organs or tissues that are derived from cells with stem potential and can self‐organize and differentiate into 3D cell masses, recapitulating the morphology and functions of their in vivo counterparts. Organoid culture is an emerging 3D culture technology, and organoids derived from various organs and tissues, such as the brain, lung, heart, liver, and kidney, have been generated. Compared with traditional bidimensional culture, organoid culture systems have the unique advantage of conserving parental gene expression and mutation characteristics, as well as long‐term maintenance of the function and biological characteristics of the parental cells in vitro. All these features of organoids open up new opportunities for drug discovery, large‐scale drug screening, and precision medicine. Another major application of organoids is disease modeling, and especially various hereditary diseases that are difficult to model in vitro have been modeled with organoids by combining genome editing technologies. Herein, we introduce the development and current advances in the organoid technology field. We focus on the applications of organoids in basic biology and clinical research, and also highlight their limitations and future perspectives. We hope that this review can provide a valuable reference for the developments and applications of organoids.

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Section: Biomedical Applications Of Organoidsmentioning

confidence: 99%

Organoids: The current status and biomedical applications

Yang

Kung

et al. 2023

MedComm

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“…As well as having immediate effects on health, they can also have long‐term effects on the environment and ecosystems. It is, therefore, worthwhile to understand the potential risks of EDCs 4,5 …”

Section: Introductionmentioning

confidence: 99%

“…It is, therefore, worthwhile to understand the potential risks of EDCs. 4,5 Humans can suffer adverse health effects when continuously exposed to EDCs, such as phenols, parabens, and phthalates. In particular, phenols, especially bisphenol A (BPA), are linked to breast cancer, obesity, and altered reproductive functions.…”

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confidence: 99%

“…It triggers DNA damage in type 2 epithelial cells as well. 5 DNA damage-mediated cell death is a crucial factor in the progression of many lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, lung cancer, and fibrotic lung diseases. It was shown that BPA can adversely affect lung development in animals.…”

mentioning

confidence: 99%

“…16 As a result of BPA exposure, bronchial eosinophilic inflammation and allergy sensitization have been observed. 5 Hence, BPA exposure is associated with chronic inflammation, oxidative stress, DNA damage, cell apoptosis and necrosis, and fibrotic infiltration of many organs in a time-dependent manner, including the lung. 17 BPA exposure is also correlated with increased inflammatory responses in the lungs, including the release of inflammatory cytokines.…”

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confidence: 99%

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Bisphenol A promotes cell death in healthy respiratory system cells through inhibition of cell proliferation and induction of G2/M cell cycle arrest

Aysin

2024

Environmental Toxicology

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Bisphenol A (BPA) is a substance that can harm the environment and human health by interfering with the normal functioning of the body's hormonal system. It is commonly found in various plastic‐based products such as cosmetics, canned foods, beverage containers, and medical equipment and as well as it can also be absorbed by inhalation. There have been limited studies on the effects of BPA on lung fibroblasts, and it is still unclear how high levels of BPA can impact respiratory system cells, particularly the lungs and trachea. In this research, we aimed to investigate the cell cycle disruption potential of BPA on respiratory system cells by examining healthy trachea and lung cells together for the first time. The findings indicated that BPA exposure can alter the healthy cells' morphology, leading to reduced cellular viability that has been assessed by MTT and SRB assays. BPA treatment was able to activate caspase3 as expected, which could cause apoptosis in treated cells. Although the highest dose of BPA did not increase the apoptotic rate of rat trachea cells, it remarkably caused them to become necrotic (52.12%). In addition to quantifying the induction of apoptosis and necrosis by BPA, cell cycle profiles were also determined using flow cytometry. Thereby, BPA treatment unexpectedly inhibited the cell cycle's progression by causing G2/M cell cycle arrest in both lung and tracheal cells, which hindered cell proliferation. The findings of the study suggested that exposure to BPA could lead to serious respiratory problems, even respiratory tract cancers via alterations in the cell cycle.

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Cucumeropsis mannii seed oil protects against Bisphenol A‐induced testicular mitochondrial damages

Aja

Ogwoni

Agu

et al. 2023

Food Science & Nutrition

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There has been increasing search for the ameliorative properties of seed oils against toxicants. bisphenol A acts as an estrogenic endocrine‐disrupting chemical capable of causing male infertility. This study aimed to explore Cucumeropsis mannii seed oil effects against mitochondrial damage in rats using bisphenol A. Forty‐eight rats were randomly assigned to six groups (n = 6) of eight rats each and fed the same food and water for 6 weeks. The group A rats were given 1 mL olive oil, while the ones in group B were given bisphenol A at 100 mL/kg body weight via oral route. Group C received C. mannii seed oil 7.5 mL/kg body weight C. mannii seed oil, while group D, group E, and group F were pre‐administered bisphenol A at 100 mL/kg body weight, followed by treatment with C. mannii seed oil at 7.5, 5, and 2.5 mL/kg body weight, respectively. Antioxidant enzymes, glutathione, reactive oxygen species, testicular volume, malondialdehyde, body weight, and testicular studies were done using standard methods. The results of the bisphenol A‐administered group showed a significant decrease in the antioxidant enzymes, glutathione, body weight, and testicular volume with elevation in the levels of reactive oxygen species, malondialdehyde, and testicular indices. BPA + CMSO‐treated group showed a significant increase in GPx activity compared with BPA‐exposed rats. CMSO treatment significantly increased catalase activity in comparison with that of rats exposed to BPA. Remarkably, C. mannii seed oil and bisphenol A co‐administration significantly reversed the abnormalities observed in the dysregulated biochemical biomarkers. Our findings suggest that C. mannii seed oil has considerable antioxidant potential which can be explored in therapeutic development against systemic toxicity induced by exposure to bisphenol A. Cucumeropsis mannii seed oil protects against bisphenol A‐induced testicular mitochondria damages.

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Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

Cited by 26 publications

References 337 publications

Organoids: The current status and biomedical applications

Organoids: The current status and biomedical applications

Bisphenol A promotes cell death in healthy respiratory system cells through inhibition of cell proliferation and induction of G2/M cell cycle arrest

Cucumeropsis mannii seed oil protects against Bisphenol A‐induced testicular mitochondrial damages

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