Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development

Wang, Lu; Yan, Yonghuan; Wu, Linfang; Peng, Jinyong

doi:10.1016/j.phrs.2023.106925

Cited by 19 publications

(2 citation statements)

References 221 publications

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“…Medicines such as atorvastatin calcium tablets and fenofibrate are commonly used to manage blood lipid levels [ 108 ]. However, using lipid-lowering medications can lead to certain negative side effects [ 109 ]. Therefore, finding novel medications that treat NAFLD with great efficacy and few adverse effects is urgent.…”

Section: Mechanism Of Ck Against Metabolic Diseasesmentioning

confidence: 99%

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Morshed,

Akter,

Karim

et al. 2024

CIMB

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Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bioconversion processes. Current research shows that CK has a wide range of pharmacological actions, including boosting osteogenesis, lipid and glucose metabolism, lipid oxidation, insulin resistance, and anti-inflammatory and anti-apoptosis properties. Further research on the bioavailability and toxicology of CK can advance its medicinal application. The purpose of this review is to lay the groundwork for future clinical studies and the development of CK as a therapy for metabolic disorders. Furthermore, the toxicology and pharmacology of CK are investigated as well in this review. The findings indicate that CK primarily modulates signaling pathways associated with AMPK, SIRT1, PPARs, WNTs, and NF-kB. It also demonstrates a positive therapeutic effect of CK on non-alcoholic fatty liver disease (NAFLD), obesity, hyperlipidemia, diabetes, and its complications, as well as osteoporosis. Additionally, the analogues of CK showed more bioavailability, less toxicity, and more efficacy against disease states. Enhancing bioavailability and regulating hazardous variables are crucial for its use in clinical trials.

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Section: Mechanism Of Ck Against Metabolic Diseasesmentioning

confidence: 99%

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Morshed,

Akter,

Karim

et al. 2024

CIMB

View full text Add to dashboard Cite

show abstract

“…), and terpenes (celastrol, boswellic acid, etc .). 6–10 One of the central regulators of cellular and organic metabolism in eukaryotes is AMP-activated protein kinase (AMPK), an evolutionarily conserved serine/threonine protein kinase that is activated when intracellular ATP levels are reduced. 11,12 AMPK is a sensor that balances the energy state of cells and plays a crucial role in regulating lipid metabolism.…”

Section: Introductionmentioning

confidence: 99%

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

Xie,

Hao,

Xie

et al. 2024

Food Funct.

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Natural products: A potential immunomodulators against inflammatory-related diseases

Sai Priya,

Ramalingam,

Suresh Babu

2024

Inflammopharmacol

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Natural products in non-alcoholic fatty liver disease (NAFLD): Novel lead discovery for drug development

Cited by 19 publications

References 221 publications

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Bioconversion, Pharmacokinetics, and Therapeutic Mechanisms of Ginsenoside Compound K and Its Analogues for Treating Metabolic Diseases

Acetylated pelargonidin-3-O-glucoside alleviates hepatocyte lipid deposition through activating the AMPK-mediated lysosome-autophagy pathway and redox state

Natural products: A potential immunomodulators against inflammatory-related diseases

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