2022
DOI: 10.1101/2022.06.27.497873
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Natural products lysobactin and sorangicin A show in vitro activity against Mycobacterium abscessus complex

Abstract: The prevalence of lung disease caused by Mycobacterium abscessus is increasing among patients with cystic fibrosis. M. abscessus is a multidrug resistant opportunistic pathogen that is notoriously difficult to treat due to a lack of efficacious therapeutic regimens. Currently, there are no standard regimens, and treatment guidelines are based empirically on drug susceptibility testing. Thus, novel antibiotics are required. Natural products represent a vast pool of biologically active compounds that have a hist… Show more

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