Natural Products of Lactococcus Overcome Nosocomial Infection in Some of Baghdad Hospitals in Iraq

Abstract

Nosocomial infections (NIs) are hospital-acquired associated infections, and also contracted due to the infections or toxins that exist in some location, like hospital. Therefore in our study, 4 Lactic acid bacteria (LAB) isolates were obtained from dairy product (Lactobacillus brevis, L. acidophilus, Lactococcus raffinolactis and Lactococcus lactis) and were tested for Bacteriocin production to select Lactococcus lactis among them. Cell free supernatant (CFS), Lipid and partial purification of protein La. Lactis had high inhibitory effect against test pathogens (E. coli, Bacillus cereus, Staphylococcus aureus and Streptococcus). 30 isolates that diagnosed by Vitec, were isolated from (3) hospitals in Baghdad/ Iraq. The results showed that the bacteriocin exhibited higher inhibition activity against the microorganisms (that isolated from hospitals), so we recommended that La. lactis is a good natural agent candidate that could be inhibitor to microorganism isolated from hospitals, so it is a good factor to decrease nosocomial infections.

The combined effect of Weisella cibaria and Fusarium oxysporum nanoparticles on cervical cancer cells

“…al. 18 and Mohsin et al 19 showed that Weisella always appears in culture as white colonies, small, smooth and shiny. The presence of several fractions (contained proteins with a molecular mass less than 500 Da) may be the cause of T1 inhibition of studied bacteria; in vitro findings related to the peptidic nature of the LAB species linked to bacteria inhibition 20,21,22 , or may be occurrence the inhibition due to that some compounds work on the cell membrane and depolarize it, So, the cell wall synthesis inhibition, these compounds known as Diacetyl organic acids (lactic , formic, acetic and propionic) the pH of the medium was reduced as a result of this, So can compete for nutrients 20,23,24 .…”

“…It is certain and natural that all types of probiotics prove their strong efficacy because in many sources they have proven wide range of inhibition [38][39] . It is also extended to nosocomial infection 19 , against parasite 21 , eye pathogen 22 , or against pathogenic microorganisms [40][41][42] , and proved that it gives the strongest effect when two or more types of probiotics are combined 43 . All of the previous studies that were interested in the inhibitory effect of LAB indicated that are not failed never in its role as anti-microbial agent 44 .…”